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Nakamura K, Murakami M, Miura D, et al. Beta-Blockers and Oxidative Stress in Patients with Heart Failure. Pharmaceuticals (Basel). 2011;4(8):1088-100doi: 10.3390/ph4081088.
Nakamura, K., Murakami, M., Miura, D., Yunoki, K., Enko, K., Tanaka, M., Saito, Y., Nishii, N., Miyoshi, T., Yoshida, M., Oe, H., Toh, N., Nagase, S., Kohno, K., Morita, H., Matsubara, H., Kusano, K. F., Ohe, T., & Ito, H. (2011). Beta-Blockers and Oxidative Stress in Patients with Heart Failure. Pharmaceuticals (Basel, Switzerland), 4(8), 1088-100. https://doi.org/10.3390/ph4081088
Nakamura, Kazufumi, et al. "Beta-Blockers and Oxidative Stress in Patients with Heart Failure." Pharmaceuticals (Basel, Switzerland) vol. 4,8 (2011): 1088-100. doi: https://doi.org/10.3390/ph4081088
Nakamura K, Murakami M, Miura D, Yunoki K, Enko K, Tanaka M, Saito Y, Nishii N, Miyoshi T, Yoshida M, Oe H, Toh N, Nagase S, Kohno K, Morita H, Matsubara H, Kusano KF, Ohe T, Ito H. Beta-Blockers and Oxidative Stress in Patients with Heart Failure. Pharmaceuticals (Basel). 2011 Aug 05;4(8):1088-100. doi: 10.3390/ph4081088. PMID: 26791643; PMCID: PMC4058661.
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Pharmaceuticals (Basel). 2011 Aug 05;4(8):1088-100. doi: 10.3390/ph4081088.

Beta-Blockers and Oxidative Stress in Patients with Heart Failure.

Pharmaceuticals (Basel, Switzerland)

Kazufumi Nakamura, Masato Murakami, Daiji Miura, Kei Yunoki, Kenki Enko, Masamichi Tanaka, Yukihiro Saito, Nobuhiro Nishii, Toru Miyoshi, Masashi Yoshida, Hiroki Oe, Norihisa Toh, Satoshi Nagase, Kunihisa Kohno, Hiroshi Morita, Hiromi Matsubara, Kengo F Kusano, Tohru Ohe, Hiroshi Ito

Affiliations

  1. Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. [email protected].
  2. Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
  3. Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
  4. Division of Cardiology, National Hospital Organization Okayama Medical Center, 1711-1 Tamasu, Kita-ku, Okayama 701-1192, Japan.

PMID: 26791643 PMCID: PMC4058661 DOI: 10.3390/ph4081088

Abstract

Oxidative stress has been implicated in the pathogenesis of heart failure. Reactive oxygen species (ROS) are produced in the failing myocardium, and ROS cause hypertrophy, apoptosis/cell death and intracellular Ca(2+) overload in cardiac myocytes. ROS also cause damage to lipid cell membranes in the process of lipid peroxidation. In this process, several aldehydes, including 4-hydroxy-2-nonenal (HNE), are generated and the amount of HNE is increased in the human failing myocardium. HNE exacerbates the formation of ROS, especially H₂O₂ and ·OH, in cardiomyocytes and subsequently ROS cause intracellular Ca(2+) overload. Treatment with beta-blockers such as metoprolol, carvedilol and bisoprolol reduces the levels of oxidative stress, together with amelioration of heart failure. This reduction could be caused by several possible mechanisms. First, the beta-blocking effect is important, because catecholamines such as isoproterenol and norepinephrine induce oxidative stress in the myocardium. Second, anti-ischemic effects and negative chronotropic effects are also important. Furthermore, direct antioxidative effects of carvedilol contribute to the reduction of oxidative stress. Carvedilol inhibited HNE-induced intracellular Ca(2+) overload. Beta-blocker therapy is a useful antioxidative therapy in patients with heart failure.

Keywords: beta-blocker; heart failure; oxidative stress

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