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Zheng Y, Zhou H, Dunstan CR, et al. The role of the bone microenvironment in skeletal metastasis. J Bone Oncol. 2012;2(1):47-57doi: 10.1016/j.jbo.2012.11.002.
Zheng, Y., Zhou, H., Dunstan, C. R., Sutherland, R. L., & Seibel, M. J. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of bone oncology, 2(1), 47-57. https://doi.org/10.1016/j.jbo.2012.11.002
Zheng, Yu, et al. "The role of the bone microenvironment in skeletal metastasis." Journal of bone oncology vol. 2,1 (2013): 47-57. doi: https://doi.org/10.1016/j.jbo.2012.11.002
Zheng Y, Zhou H, Dunstan CR, Sutherland RL, Seibel MJ. The role of the bone microenvironment in skeletal metastasis. J Bone Oncol. 2012 Dec 11;2(1):47-57. doi: 10.1016/j.jbo.2012.11.002. eCollection 2013 Feb. PMID: 26909265; PMCID: PMC4723345.
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J Bone Oncol. 2012 Dec 11;2(1):47-57. doi: 10.1016/j.jbo.2012.11.002. eCollection 2013 Feb.

The role of the bone microenvironment in skeletal metastasis.

Journal of bone oncology

Yu Zheng, Hong Zhou, Colin R Dunstan, Robert L Sutherland, Markus J Seibel

Affiliations

  1. Bone Research Program, ANZAC Research Institute, University of Sydney, NSW 2139, Australia; The Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
  2. Bone Research Program, ANZAC Research Institute, University of Sydney, NSW 2139, Australia.
  3. Bone Research Program, ANZAC Research Institute, University of Sydney, NSW 2139, Australia; Department of Biomedical Engineering, University of Sydney, NSW 2006, Australia.
  4. The Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
  5. Bone Research Program, ANZAC Research Institute, University of Sydney, NSW 2139, Australia; Department of Endocrinology & Metabolism, Concord Hospital, Concord, Sydney, NSW 2139, Australia.

PMID: 26909265 PMCID: PMC4723345 DOI: 10.1016/j.jbo.2012.11.002

Abstract

The bone microenvironment provides a fertile soil for cancer cells. It is therefore not surprising that the skeleton is a frequent site of cancer metastasis. It is believed that reciprocal interactions between tumour and bone cells, known as the "vicious cycle of bone metastasis" support the establishment and orchestrate the expansion of malignant cancers in bone. While the full range of molecular mechanisms of cancer metastasis to bone remain to be elucidated, recent research has deepened our understanding of the cell-mediated processes that may be involved in cancer cell survival and growth in bone. This review aims to address the importance of the bone microenvironment in skeletal cancer metastasis and discusses potential therapeutic implications of novel insights.

Keywords: Bone metastasis; Bone microenvironment; Bone remodelling; Cancer

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