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Nat Prod Res. 2016 Dec;30(23):2669-2674. doi: 10.1080/14786419.2016.1143829. Epub 2016 Mar 11.

New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production.

Natural product research

Yu-Peng Li, Si-Meng Zhao, Jun-Ju Xu, Guang-Zhi Zeng, Yan Li, Ning-Hua Tan, Ye Yang

Affiliations

  1. a Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials , Yunnan Agricultural University , Kunming , P.R. China.
  2. b School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products , Kunming Medical University , Kunming , P.R. China.
  3. c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming , P.R. China.
  4. d Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming , P.R. China.

PMID: 26965832 DOI: 10.1080/14786419.2016.1143829

Abstract

Two new labdane diterpenes, hedychenoids A (1) and B (2), were isolated from the rhizomes of Hedychium yunnanense, together with four known ones hedychenone (3), forrestin A (4), villosin (5) and calcaratarin C (6). Their structures were determined on the basis of NMR (1D and 2D) and mass spectroscopic analysis. Compounds 2, 3 and 5 exhibited cytotoxicity against SGC-7901 with IC

Keywords: ; Zingiberaceae; cytotoxicity; inhibition of NO production; labdane diterpenes

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