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Cheon JH, Kim SY, Son JY, et al. Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury. Toxicol Res. 2016;32(1):47-56doi: 10.5487/TR.2016.32.1.047.
Cheon, J. H., Kim, S. Y., Son, J. Y., Kang, Y. R., An, J. H., Kwon, J. H., Song, H. S., Moon, A., Lee, B. M., & Kim, H. S. (2016). Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury. Toxicological research, 32(1), 47-56. https://doi.org/10.5487/TR.2016.32.1.047
Cheon, Ji Hyun, et al. "Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury." Toxicological research vol. 32,1 (2016): 47-56. doi: https://doi.org/10.5487/TR.2016.32.1.047
Cheon JH, Kim SY, Son JY, Kang YR, An JH, Kwon JH, Song HS, Moon A, Lee BM, Kim HS. Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury. Toxicol Res. 2016 Jan;32(1):47-56. doi: 10.5487/TR.2016.32.1.047. Epub 2016 Jan 31. PMID: 26977258; PMCID: PMC4780241.
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Toxicol Res. 2016 Jan;32(1):47-56. doi: 10.5487/TR.2016.32.1.047. Epub 2016 Jan 31.

Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury.

Toxicological research

Ji Hyun Cheon, Sun Young Kim, Ji Yeon Son, Ye Rim Kang, Ji Hye An, Ji Hoon Kwon, Ho Sub Song, Aree Moon, Byung Mu Lee, Hyung Sik Kim

Affiliations

  1. School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
  2. College of Pharmacy, Duksung Women's University, Seoul, Korea.

PMID: 26977258 PMCID: PMC4780241 DOI: 10.5487/TR.2016.32.1.047

Abstract

The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important. Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr) and blood urea nitrogen (BUN), are frequently used to diagnose AKI. However, these biomarkers increase only after significant structural damage has occurred. Recent efforts have focused on identification and validation of new noninvasive biomarkers for the early detection of AKI, prior to extensive structural damage. Furthermore, AKI biomarkers can provide valuable insight into the molecular mechanisms of this complex and heterogeneous disease. Our previous study suggested that pyruvate kinase M2 (PKM2), which is excreted in the urine, is a sensitive biomarker for nephrotoxicity. To appropriately and optimally utilize PKM2 as a biomarker for AKI requires its complete characterization. This review highlights the major studies that have addressed the diagnostic and prognostic predictive power of biomarkers for AKI and assesses the potential usage of PKM2 as an early biomarker for AKI. We summarize the current state of knowledge regarding the role of biomarkers and the molecular and cellular mechanisms of AKI. This review will elucidate the biological basis of specific biomarkers that will contribute to improving the early detection and diagnosis of AKI.

Keywords: Acute kidney injury; Biomarker; Pyruvate kinase M2

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