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Tsuzuki Y, Yamashita Y, Hattori Y, et al. Pain-reducing anesthesia prevents oxidative stress in human term placenta. J Clin Biochem Nutr. 2016;58(2):156-60doi: 10.3164/jcbn.15-138.
Tsuzuki, Y., Yamashita, Y., Hattori, Y., Hua Li, G., Akatsuka, S., Kotani, T., Kikkawa, F., Naiki-Ito, A., Takahashi, S., Nishiwaki, K., & Toyokuni, S. (2016). Pain-reducing anesthesia prevents oxidative stress in human term placenta. Journal of clinical biochemistry and nutrition, 58(2), 156-60. https://doi.org/10.3164/jcbn.15-138
Tsuzuki, Yoko, et al. "Pain-reducing anesthesia prevents oxidative stress in human term placenta." Journal of clinical biochemistry and nutrition vol. 58,2 (2016): 156-60. doi: https://doi.org/10.3164/jcbn.15-138
Tsuzuki Y, Yamashita Y, Hattori Y, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S. Pain-reducing anesthesia prevents oxidative stress in human term placenta. J Clin Biochem Nutr. 2016 Mar;58(2):156-60. doi: 10.3164/jcbn.15-138. Epub 2016 Feb 17. PMID: 27013783; PMCID: PMC4788402.
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J Clin Biochem Nutr. 2016 Mar;58(2):156-60. doi: 10.3164/jcbn.15-138. Epub 2016 Feb 17.

Pain-reducing anesthesia prevents oxidative stress in human term placenta.

Journal of clinical biochemistry and nutrition

Yoko Tsuzuki, Yoriko Yamashita, Yuka Hattori, Guang Hua Li, Shinya Akatsuka, Tomomi Kotani, Fumitaka Kikkawa, Aya Naiki-Ito, Satoru Takahashi, Kimitoshi Nishiwaki, Shinya Toyokuni

Affiliations

  1. Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan; Department of Anesthesiology and Resuscitation, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
  2. Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
  3. Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan; Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
  4. Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan.
  5. Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
  6. Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
  7. Department of Anesthesiology and Resuscitation, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan.

PMID: 27013783 PMCID: PMC4788402 DOI: 10.3164/jcbn.15-138

Abstract

Anesthesia is sometimes used for the reduction of maternal pain in normal human term labor, but whether the drugs affect oxidative stress remains unclear. The placenta serves as an interface between the maternal and fetal vasculature. In this study, we immunohistochemically analyzed two markers for oxidative stress, namely 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal-modified proteins (HNE), using placentas from 21 cases of normal tansvaginal delivery (V group), 20 Caesarean sections (C group), and 17 normal transvaginal deliveries with epidural anesthesia (E group). 8-OHdG staining in the nuclei of trophoblasts lining the chorionic villi was significantly stronger in the V group either compared with the C or E group (p<0.001), without significant differences in the C and E groups (p = 0.792). Moderate to intense staining by HNE of the intravascular serum of chorionic villi vasculature was frequently observed in the placentas from the V group, but less frequently of those in either C or E groups (p<0.001), nor the p value comparing the C and E groups was significant (p = 0.128) for HNE staining. Our results suggest that although the role of oxidative stress and its influences on fetal state in the placenta in labor remains unclear, it seems to be lessened by epidural anesthesia.

Keywords: 4-hydroxy-2-nonenal-modified proteins; 8-hydroxy-2'-deoxyguanosine; anesthesia; oxidative stress; placenta

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