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Showing 1 to 12 of 101 entries
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The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma.

Gastrointestinal tumors

Kobayashi S, Tomokuni A, Takahashi H, Akita H, Sugimura K, Miyoshi N, Moon JH, Yasui M, Omori T, Ohue M, Fujiwara Y, Yano M, Sakon M.
PMID: 28611981
Gastrointest Tumors. 2017 Mar;3(3):141-152. doi: 10.1159/000455955. Epub 2017 Feb 08.

BACKGROUND/AIMS: Alpha-fetoprotein (AFP) mRNA-expressing cells are candidates for circulating tumor cells in hepatocellular carcinoma. We analyzed portal vein blood, peripheral blood, and peritoneal lavage samples to detect the presence of AFP mRNA-expressing cells, and explored their relationship with metastasis.METHODS:...

Pain-reducing anesthesia prevents oxidative stress in human term placenta.

Journal of clinical biochemistry and nutrition

Tsuzuki Y, Yamashita Y, Hattori Y, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S.
PMID: 27013783
J Clin Biochem Nutr. 2016 Mar;58(2):156-60. doi: 10.3164/jcbn.15-138. Epub 2016 Feb 17.

Anesthesia is sometimes used for the reduction of maternal pain in normal human term labor, but whether the drugs affect oxidative stress remains unclear. The placenta serves as an interface between the maternal and fetal vasculature. In this study,...

Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report.

Surgical case reports

Hara T, Fujiwara Y, Takahashi H, Sugimura K, Moon JH, Omori T, Miyoshi N, Tomokuni A, Akita H, Kobayashi S, Yasui M, Miyata H, Ohue M, Sakon M, Tomita Y, Yano M.
PMID: 28357816
Surg Case Rep. 2017 Dec;3(1):51. doi: 10.1186/s40792-017-0326-y. Epub 2017 Mar 30.

BACKGROUND: Pancreatic neoplasms are usually characterized by ductal, acinar, or endocrine differentiation. Mixed exocrine and endocrine pancreatic tumours are extremely rare. Here, we report a case of pancreatic mixed acinar-endocrine carcinoma (MAEC) with multiple synchronous liver metastases that were...

A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.

Journal of clinical biochemistry and nutrition

Okazaki Y, Iqbal M, Kawakami N, Yamamoto Y, Toyokuni S, Okada S.
PMID: 21103028
J Clin Biochem Nutr. 2010 Nov;47(3):198-207. doi: 10.3164/jcbn.10-52. Epub 2010 Sep 16.

It is beneficial to seek scientific basis for the effects of functional foods. Natural pigments derived from plants are widely known as possible antioxidants. Black soybean contains a larger amount of anthocyanins than regular soybean. Here we studied the...

A novel method for efficient collection of normal mesothelial cells in vivo.

Journal of clinical biochemistry and nutrition

Jiang L, Yamashita Y, Toyokuni S.
PMID: 20490323
J Clin Biochem Nutr. 2010 May;46(3):265-8. doi: 10.3164/jcbn.10-01. Epub 2010 Apr 10.

Asbestos-induced mesothelioma is a challenging social problem in many countries, and oxidative stress via iron is closely associated with its carcinogenesis. Mesothelioma is thought to originate from the mesothelial cells that cover the somatic cavity such as pleural, pericardial...

Preclinical evaluation of an O(6)-methylguanine-DNA methyltransferase-siRNA/liposome complex administered by convection-enhanced delivery to rat and porcine brains.

American journal of translational research

Tsujiuchi T, Natsume A, Motomura K, Kondo G, Ranjit M, Hachisu R, Sugimura I, Tomita S, Takehara I, Woolley M, Barua NU, Gill SS, Bienemann AS, Yamashita Y, Toyokuni S, Wakabayashi T.
PMID: 24489997
Am J Transl Res. 2014 Jan 15;6(2):169-78. eCollection 2014.

The main determinant of glioblastoma (GBM) resistance to temozolomide (TMZ) is thought to be O(6)-methylguanine-DNA methyltransferase (MGMT), which is a DNA-repair enzyme that removes alkyl groups from the O(6)-position of guanine. Previously, we reported that a MGMT-siRNA/cationic liposome complex...

Thermoelectric response near a quantum critical point of β-YbAlB4 and YbRh2Si2: a comparative study.

Physical review letters

Machida Y, Tomokuni K, Ogura C, Izawa K, Kuga K, Nakatsuji S, Lapertot G, Knebel G, Brison JP, Flouquet J.
PMID: 23102346
Phys Rev Lett. 2012 Oct 12;109(15):156405. doi: 10.1103/PhysRevLett.109.156405. Epub 2012 Oct 09.

The thermoelectric coefficients have been measured down to a very low temperature for the Yb-based heavy-fermion compounds β-YbAlB4 and YbRh2Si2, often considered as model systems for the local quantum criticality case. We observe a striking difference in the behavior...

Bovine lactoferrin ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.

Journal of clinical biochemistry and nutrition

Okazaki Y, Kono I, Kuriki T, Funahashi S, Fushimi S, Iqbal M, Okada S, Toyokuni S.
PMID: 22962523
J Clin Biochem Nutr. 2012 Sep;51(2):84-90. doi: 10.3164/jcbn.11-100. Epub 2012 Aug 04.

Milk provides a well-balanced source of amino acids and other ingredients. One of the functional ingredients in milk is lactoferrin (LF). LF presents a wide variety of bioactivities and functions as a radical scavenger in models using iron-ascorbate complexes...

Effect of .

Oncology letters

Tomokuni A, Eguchi H, Hoshino H, Dewi DL, Nishikawa S, Kano Y, Miyoshi N, Tojo A, Kobayashi S, Gotoh N, Hinohara K, Fusaki N, Saito T, Suemizu H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Doki Y, Mori M, Ishii H, Nagano H.
PMID: 24137324
Oncol Lett. 2013 Aug;6(2):323-328. doi: 10.3892/ol.2013.1418. Epub 2013 Jun 20.

Cancer is initiated by the transformation of stem cells or progenitor cells via a dedifferentiation process that leads to cancer stem cells; however, the process involves the activation of growth-promoting oncogenes and the inactivation of growth-constraining tumor suppressor genes....

Verification of the Wiedemann-Franz law in YbRh2Si2 at a quantum critical point.

Physical review letters

Machida Y, Tomokuni K, Izawa K, Lapertot G, Knebel G, Brison JP, Flouquet J.
PMID: 25167518
Phys Rev Lett. 2013 Jun 07;110(23):236402. doi: 10.1103/PhysRevLett.110.236402. Epub 2013 Jun 07.

The thermal conductivity measurements are performed on the heavy-fermion compound YbRh(2)Si(2) down to 0.04 K and under magnetic fields through a quantum critical point (QCP) at B(c)=0.66  T∥c axis. In the limit as T→0, we find that the Wiedemann-Franz...

Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model.

Oncotarget

Ohara Y, Chew SH, Misawa N, Wang S, Somiya D, Nakamura K, Kajiyama H, Kikkawa F, Tsuyuki Y, Jiang L, Yamashita K, Sekido Y, Lipson KE, Toyokuni S.
PMID: 29719620
Oncotarget. 2018 Apr 06;9(26):18494-18509. doi: 10.18632/oncotarget.24892. eCollection 2018 Apr 06.

Malignant mesothelioma is an aggressive neoplasm with no particularly effective treatments. We previously reported that overexpression of connective tissue growth factor (CTGF/CCN2) promotes mesothelioma growth, thus suggesting it as a novel molecular target. A human monoclonal antibody that antagonizes...

Acute fulminant invasive pulmonary aspergillosis in an immunocompetent host: An autopsy case report.

Medical mycology case reports

Ohara Y, Ito T, Ito M, Yamashita K, Toyokuni S.
PMID: 29552460
Med Mycol Case Rep. 2018 Feb 09;20:39-42. doi: 10.1016/j.mmcr.2018.02.002. eCollection 2018 Jun.

A 62-year-old previously healthy male who was a welder/smoker/drinker was admitted to Kani Tono Hospital for severe hypoxemia (Day 0). Initial physical and radiological examinations suggested an acute exacerbation of chronic obstructive pulmonary disease. However, respiratory failure developed rapidly,...

Showing 1 to 12 of 101 entries