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Zheng J, Wang M, Wei W, et al. Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease. Front Nutr. 2016;3:7doi: 10.3389/fnut.2016.00007.
Zheng, J., Wang, M., Wei, W., Keller, J. N., Adhikari, B., King, J. F., King, M. L., Peng, N., & Laine, R. A. (2016). Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease. Frontiers in nutrition, 37. https://doi.org/10.3389/fnut.2016.00007
Zheng, Jolene, et al. "Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease." Frontiers in nutrition vol. 3 (2016): 7. doi: https://doi.org/10.3389/fnut.2016.00007
Zheng J, Wang M, Wei W, Keller JN, Adhikari B, King JF, King ML, Peng N, Laine RA. Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease. Front Nutr. 2016 Mar 07;3:7. doi: 10.3389/fnut.2016.00007. eCollection 2016. PMID: 27014695; PMCID: PMC4780318.
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Front Nutr. 2016 Mar 07;3:7. doi: 10.3389/fnut.2016.00007. eCollection 2016.

Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease.

Frontiers in nutrition

Jolene Zheng, Mingming Wang, Wenqian Wei, Jeffrey N Keller, Binita Adhikari, Jason F King, Michael L King, Nan Peng, Roger A Laine

Affiliations

  1. School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA, USA; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  2. School of Nutrition and Food Sciences, Louisiana State University , Baton Rouge, LA , USA.
  3. Department of Veterinary Science, College of Agriculture, Louisiana State University, Baton Rouge, LA, USA; School of Life Sciences, Fudan University, Shanghai, China.
  4. Pennington Biomedical Research Center, Louisiana State University , Baton Rouge, LA , USA.
  5. Nicholls State University, Thibodaux, LA, USA; Louisiana Biomedical Research Network (LBRN) Summer Research Program (2010), Baton Rouge, LA, USA.
  6. Department of Biological Sciences, Louisiana State University and A&M College, Baton Rouge, LA, USA; Department of Chemistry, Louisiana State University and A&M College, Baton Rouge, LA, USA.
  7. School of Life Sciences, Fudan University , Shanghai , China.

PMID: 27014695 PMCID: PMC4780318 DOI: 10.3389/fnut.2016.00007

Abstract

Lectins from dietary plants have been shown to enhance drug absorption in the gastrointestinal tract of rats, be transported trans-synaptically as shown by tracing of axonal and dendritic paths, and enhance gene delivery. Other carbohydrate-binding protein toxins are known to traverse the gut intact in dogs. Post-feeding rhodamine- or TRITC-tagged dietary lectins, the lectins were tracked from gut to dopaminergic neurons (DAergic-N) in transgenic Caenorhabditis elegans (C. elegans) [egIs1(Pdat-1:GFP)] where the mutant has the green fluorescent protein (GFP) gene fused to a dopamine transport protein gene labeling DAergic-N. The lectins were supplemented along with the food organism Escherichia coli (OP50). Among nine tested rhodamine/TRITC-tagged lectins, four, including Phaseolus vulgaris erythroagglutinin (PHA-E), Bandeiraea simplicifolia (BS-I), Dolichos biflorus agglutinin (DBA), and Arachis hypogaea agglutinin (PNA), appeared to be transported from gut to the GFP-DAergic-N. Griffonia Simplicifolia and PHA-E, reduced the number of GFP-DAergic-N, suggesting a toxic activity. PHA-E, BS-I, Pisum sativum (PSA), and Triticum vulgaris agglutinin (Succinylated) reduced fluorescent intensity of GFP-DAergic-N. PHA-E, PSA, Concanavalin A, and Triticum vulgaris agglutinin decreased the size of GFP-DAergic-N, while BS-I increased neuron size. These observations suggest that dietary plant lectins are transported to and affect DAergic-N in C. elegans, which support Braak and Hawkes' hypothesis, suggesting one alternate potential dietary etiology of Parkinson's disease (PD). A recent Danish study showed that vagotomy resulted in 40% lower incidence of PD over 20 years. Differences in inherited sugar structures of gut and neuronal cell surfaces may make some individuals more susceptible in this conceptual disease etiology model.

Keywords: Caenorhabditis elegans; dopamine transporter; dopaminergic neurons; fluorescence; plant lectins

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