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Tam JM, Mansour MK, Acharya M, et al. The Role of Autophagy-Related Proteins in Candida albicans Infections. Pathogens. 2016;5(2)doi: 10.3390/pathogens5020034.
Tam, J. M., Mansour, M. K., Acharya, M., Sokolovska, A., Timmons, A. K., Lacy-Hulbert, A., & Vyas, J. M. (2016). The Role of Autophagy-Related Proteins in Candida albicans Infections. Pathogens (Basel, Switzerland), 5(2), . https://doi.org/10.3390/pathogens5020034
Tam, Jenny M, et al. "The Role of Autophagy-Related Proteins in Candida albicans Infections." Pathogens (Basel, Switzerland) vol. 5,2 (2016). doi: https://doi.org/10.3390/pathogens5020034
Tam JM, Mansour MK, Acharya M, Sokolovska A, Timmons AK, Lacy-Hulbert A, Vyas JM. The Role of Autophagy-Related Proteins in Candida albicans Infections. Pathogens. 2016 Mar 29;5(2). doi: 10.3390/pathogens5020034. PMID: 27043636; PMCID: PMC4931385.
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Pathogens. 2016 Mar 29;5(2). doi: 10.3390/pathogens5020034.

The Role of Autophagy-Related Proteins in Candida albicans Infections.

Pathogens (Basel, Switzerland)

Jenny M Tam, Michael K Mansour, Mridu Acharya, Anna Sokolovska, Allison K Timmons, Adam Lacy-Hulbert, Jatin M Vyas

Affiliations

  1. Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. [email protected].
  2. Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. [email protected].
  3. Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA. [email protected].
  4. Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. [email protected].
  5. Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. [email protected].
  6. Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA. [email protected].
  7. Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. [email protected].

PMID: 27043636 PMCID: PMC4931385 DOI: 10.3390/pathogens5020034

Abstract

Autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. A marker in the autophagic process is the reversible conjugation of LC3, a membrane scaffolding protein, to double membrane autophagosomes. Recently, a role for LC3 in the elimination of pathogenic bacteria and fungi, including Candida albicans (C. albicans), was demonstrated, but these organisms reside in single membrane phagosomes. This process is distinct from autophagy and is termed LC3-associated phagocytosis (LAP). This review will detail the hallmarks of LAP that distinguish it from classical autophagy and review the role of autophagy proteins in host response to C. albicans and other pathogenic fungi.

Keywords: Aspergillus fumigatus; Candida albicans; Dectin-1; LC3; LC3-associated phagocytosis (LAP); autophagy; innate immunity

References

  1. Cell Host Microbe. 2008 Nov 13;4(5):458-69 - PubMed
  2. Cell Microbiol. 2008 Sep;10(9):1747-56 - PubMed
  3. Infect Immun. 2011 Dec;79(12):4858-67 - PubMed
  4. J Biol Chem. 2000 Jun 30;275(26):20157-67 - PubMed
  5. Immunity. 2005 Apr;22(4):507-17 - PubMed
  6. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6226-31 - PubMed
  7. J Infect Dis. 2014 Dec 1;210(11):1844-54 - PubMed
  8. Science. 2012 Jun 8;336(6086):1314-7 - PubMed
  9. Immunity. 2007 Jul;27(1):11-21 - PubMed
  10. J Biol Chem. 2011 Jan 7;286(1):185-91 - PubMed
  11. Cell. 2004 Dec 17;119(6):753-66 - PubMed
  12. Blood. 2004 Dec 15;104(13):4038-45 - PubMed
  13. Nat Cell Biol. 2011 Oct 16;13(11):1335-43 - PubMed
  14. J Immunol. 2016 Mar 1;196 (5):2249-61 - PubMed
  15. PLoS Pathog. 2014 Feb 20;10(2):e1003873 - PubMed
  16. J Biol Chem. 2011 Jul 29;286(30):26987-95 - PubMed
  17. J Biol Chem. 2012 Oct 5;287(41):34149-56 - PubMed
  18. Nat Immunol. 2007 Jun;8(6):619-29 - PubMed
  19. Autophagy. 2014 Jun;10(6):1141-2 - PubMed
  20. Med Mycol. 2014 May;52(4):333-41 - PubMed
  21. N Engl J Med. 2009 Oct 29;361(18):1760-7 - PubMed
  22. PLoS One. 2011;6(11):e27972 - PubMed
  23. Clin Infect Dis. 2015 Apr 15;60(8):1176-83 - PubMed
  24. Nat Commun. 2013;4:1342 - PubMed
  25. Int J Antimicrob Agents. 2010 Dec;36(6):531-6 - PubMed
  26. Blood. 2010 Dec 9;116(24):5394-402 - PubMed
  27. J Immunol. 2014 Feb 15;192(4):1356-60 - PubMed
  28. Immunity. 2012 Dec 14;37(6):986-97 - PubMed
  29. Nat Rev Immunol. 2006 Jan;6(1):33-43 - PubMed
  30. Proc Natl Acad Sci U S A. 2012 Nov 13;109 (46):E3168-76 - PubMed
  31. Clin Infect Dis. 2003 Nov 1;37(9):1172-7 - PubMed
  32. Nat Commun. 2015 Jan 22;6:5779 - PubMed
  33. Glycobiology. 2013 Sep;23(9):1047-51 - PubMed
  34. Infect Immun. 2009 Jul;77(7):3056-64 - PubMed
  35. Eur J Immunol. 2008 May;38(5):1194-203 - PubMed
  36. J Cell Biol. 2010 Jun 14;189(6):925-35 - PubMed
  37. J Infect Dis. 2012 Apr 15;205(8):1258-67 - PubMed
  38. Science. 2005 Jan 28;307(5709):593-6 - PubMed
  39. Nature. 2008 Sep 18;455(7211):396-400 - PubMed
  40. Eur J Immunol. 2009 Feb;39(2):507-13 - PubMed
  41. J Immunol. 2013 Aug 1;191(3):1287-99 - PubMed
  42. Int Immunol. 2013 Jan;25(1):1-10 - PubMed
  43. Cell. 2013 Jul 18;154(2):365-76 - PubMed
  44. J Biol Chem. 2008 Nov 28;283(48):33175-82 - PubMed
  45. EMBO J. 2008 Apr 9;27(7):1110-21 - PubMed
  46. Cells. 2012 Jul 30;1(3):396-408 - PubMed
  47. Eur J Clin Microbiol Infect Dis. 2014 May;33(5):711-22 - PubMed
  48. Nat Cell Biol. 2010 Dec;12(12):1154-65 - PubMed
  49. Nat Cell Biol. 2015 Jul;17 (7):893-906 - PubMed
  50. Ann N Y Acad Sci. 2008 Nov;1143:45-60 - PubMed
  51. Clin Microbiol Rev. 2007 Jan;20(1):133-63 - PubMed
  52. J Exp Med. 2003 May 5;197(9):1107-17 - PubMed
  53. Sci Signal. 2010 May 25;3(123):ra42 - PubMed
  54. J Biol Chem. 2013 May 31;288(22):16043-54 - PubMed
  55. Nat Rev Immunol. 2008 Feb;8(2):131-41 - PubMed
  56. Cell Host Microbe. 2010 Feb 18;7(2):115-27 - PubMed
  57. Nature. 2007 Dec 20;450(7173):1253-7 - PubMed
  58. Trends Cell Biol. 2007 Sep;17(9):422-7 - PubMed
  59. Cell Host Microbe. 2009 Jun 18;5(6):527-49 - PubMed
  60. EMBO J. 2007 Apr 4;26(7):1749-60 - PubMed
  61. Nat Immunol. 2010 Jan;11(1):55-62 - PubMed
  62. Cell Death Differ. 2009 Jan;16(1):57-69 - PubMed
  63. Pediatr Infect Dis J. 2015 Oct;34(10):1110-4 - PubMed
  64. Cell Death Differ. 2009 Jul;16(7):991-1005 - PubMed
  65. Nature. 2011 Jan 20;469(7330):323-35 - PubMed
  66. Blood. 2005 Oct 1;106(7):2543-50 - PubMed
  67. Am J Physiol. 1961 Feb;200:297-300 - PubMed
  68. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3526-31 - PubMed
  69. Nat Rev Immunol. 2008 Aug;8(8):607-18 - PubMed
  70. Haematologica. 2010 Apr;95(4):644-50 - PubMed
  71. Science. 2007 Mar 9;315(5817):1398-401 - PubMed
  72. J Immunol. 2010 Dec 15;185(12):7614-22 - PubMed
  73. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17396-401 - PubMed
  74. Infect Immun. 2012 Sep;80(9):3065-76 - PubMed

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