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Jordan J, Birkenfeld AL. Cardiometabolic crosstalk in obesity-associated arterial hypertension. Rev Endocr Metab Disord. 2016;17(1):19-28doi: 10.1007/s11154-016-9348-1.
Jordan, J., & Birkenfeld, A. L. (2016). Cardiometabolic crosstalk in obesity-associated arterial hypertension. Reviews in endocrine & metabolic disorders, 17(1), 19-28. https://doi.org/10.1007/s11154-016-9348-1
Jordan, Jens, and Birkenfeld, Andreas L. "Cardiometabolic crosstalk in obesity-associated arterial hypertension." Reviews in endocrine & metabolic disorders vol. 17,1 (2016): 19-28. doi: https://doi.org/10.1007/s11154-016-9348-1
Jordan J, Birkenfeld AL. Cardiometabolic crosstalk in obesity-associated arterial hypertension. Rev Endocr Metab Disord. 2016 Mar;17(1):19-28. doi: 10.1007/s11154-016-9348-1. PMID: 26961160.
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Rev Endocr Metab Disord. 2016 Mar;17(1):19-28. doi: 10.1007/s11154-016-9348-1.

Cardiometabolic crosstalk in obesity-associated arterial hypertension.

Reviews in endocrine & metabolic disorders

Jens Jordan, Andreas L Birkenfeld

Affiliations

  1. Institute for Clinical Pharmacology, Medical School Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. [email protected].
  2. Section of Metabolic Vascular Medicine, Medical Clinic III, Dresden University School of Medicine, Dresden, TU, Germany.
  3. Center for Clinical Studies, GWT-TUD GmbH, Dresden, Germany.
  4. Paul Langerhans Institute Dresden (PLID), A Member of the German Center for Diabetes Research (DZD e.V.), Dresden, Germany.

PMID: 26961160 DOI: 10.1007/s11154-016-9348-1

Abstract

Abdominal obesity and elevated blood pressure commonly occur in the same patient and are key components of the metabolic syndrome. However, the association between obesity and increased blood pressure is variable. We review mechanisms linking cardiovascular and metabolic disease in such patients including altered systemic and regional hemodynamic control, neurohumoral activation, and relative natriuretic peptide deficiency. Moreover, we discuss recent results using omics techniques providing insight in molecular pathways linking adiposity, metabolic disease, and arterial hypertension. Recognition of the mechanisms orchestrating the crosstalk between cardiovascular and metabolic regulation in individual patients may lead to better and more precise treatments. It is reassuring that recently developed cardiovascular and metabolic medications may in fact ameliorate, both, cardiovascular and metabolic risks.

Keywords: Hypertension; Individualized medicine; Metabolic syndrome; Natriuretic peptides; Neurohumoral; Obesity

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