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Tsao CR, Liao MF, Wang MH, et al. Mesenchymal Stem Cell Derived Exosomes: A New Hope for the Treatment of Cardiovascular Disease?. Acta Cardiol Sin. 2014;30(5):395-400
Tsao, C. R., Liao, M. F., Wang, M. H., Cheng, C. M., & Chen, C. H. (2014). Mesenchymal Stem Cell Derived Exosomes: A New Hope for the Treatment of Cardiovascular Disease?. Acta Cardiologica Sinica, 30(5), 395-400.
Tsao, Chen-Rong, et al. "Mesenchymal Stem Cell Derived Exosomes: A New Hope for the Treatment of Cardiovascular Disease?." Acta Cardiologica Sinica vol. 30,5 (2014): 395-400.
Tsao CR, Liao MF, Wang MH, Cheng CM, Chen CH. Mesenchymal Stem Cell Derived Exosomes: A New Hope for the Treatment of Cardiovascular Disease?. Acta Cardiol Sin. 2014 Sep;30(5):395-400. PMID: 27122816; PMCID: PMC4834956.
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Acta Cardiol Sin. 2014 Sep;30(5):395-400.

Mesenchymal Stem Cell Derived Exosomes: A New Hope for the Treatment of Cardiovascular Disease?.

Acta Cardiologica Sinica

Chen-Rong Tsao, Mau-Fang Liao, Min-Hsiung Wang, Chien-Ming Cheng, Chu-Huang Chen

Affiliations

  1. Department of Cardiology, Feng Yuan Hospital of the Ministry of Health and Welfare; ; L5 Research Center, China Medical University (CMU) Hospital, CMU;
  2. Department of Cardiology, Feng Yuan Hospital of the Ministry of Health and Welfare;
  3. Department of Cardiology, Feng Yuan Hospital of the Ministry of Health and Welfare; ; Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung;
  4. L5 Research Center, China Medical University (CMU) Hospital, CMU; ; Center for Lipid Biosciences, Kaohsiung Medical University (KMU) Hospital, KMU, Kaohsiung, Taiwan; ; Vascular and Medicinal Research, Texas Heart Institute, 6770 Bertner Avenue, MC 2-255, Houston, TX 77030; ; Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

PMID: 27122816 PMCID: PMC4834956

Abstract

UNLABELLED: Cardiovascular disease is a major target for numerous experimental stem (progenitor) cell-based therapies. Mesenchymal stem cells (MSCs) from different sources confer regenerative effects in animal models of cardiovascular disease. Some of these investigations have proceeded into phase I and II clinical trials for limb ischemia, heart failure, and acute myocardial infarction. The rationale for MSC therapy is increasingly recognized on a secretion (paracrine) rather than differentiation mechanism. Recently, several groups have demonstrated that the "exosome" is a secreted agent mediating MSC therapeutic efficacy. Unlike cell therapy, exosomes have no risk of aneuploidy, and a lower rate of immune rejection following allogeneic administration. In this short review, we will focus on the potential of using this novel therapeutic modality for the treatment of cardiovascular disease, particularly acute myocardial infarction.

KEY WORDS: Cardiovascular disease; Exosome; Mesenchymal.

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