Environ Health Perspect. 2016 Oct;124(10):1656-1661. doi: 10.1289/EHP201. Epub 2016 May 06.
Lactational Exposure to Polybrominated Diphenyl Ethers and Its Relation to Early Childhood Anthropometric Measurements.
Environmental health perspectives
Kate Hoffman, Michelle Mendez, Anna Maria Siega-Riz, Amy H Herring, Andreas Sjödin, Julie L Daniels
Affiliations
Affiliations
- UNC Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.
PMID: 27153456
PMCID: PMC5047775 DOI: 10.1289/EHP201
Abstract
BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental contaminants that may influence growth and development.
OBJECTIVE: We investigated the association between exposure to PBDEs via breast milk and anthropometric measurements in early childhood.
METHODS: The Pregnancy Infection and Nutrition (PIN) Babies studies followed a cohort of North Carolina pregnant women and their children through 36 months of age. Breast milk samples obtained at 3 months postpartum were analyzed for PBDEs. We collected height and weight records from well-baby doctor visits and also measured children during study visits (n = 246 children with > 1,400 anthropometric measurements). We assessed the relationship between breast milk concentrations of five PBDE congeners-BDEs 28, 47, 99, 100, and 153-and child's weight-for-age, height-for-age, and weight-for-height z-scores (WAZ, HAZ, and WHZ, respectively), adjusting for age; maternal age, race, prepregnancy BMI; parity; smoking during pregnancy; and breastfeeding, and stratifying by sex.
RESULTS: Overall, PBDE exposures via breast milk were not associated with early-life anthropometric measures in the PIN Babies cohort. When stratified by sex, PBDEs in milk were inversely associated with WHZ for boys; however, associations did not follow a consistent pattern across the concentration gradient and were imprecisely estimated. Among girls, PBDEs tended to be associated with increased WHZ except for BDE-153, which was inversely associated with WHZ, though all estimates were imprecisely estimated.
CONCLUSIONS: We observed little evidence of associations between early-life PBDE exposures via breast milk and anthropometric measurements overall; however, our results prompt the need for sex-specific investigations in larger cohorts.
CITATION: Hoffman K, Mendez M, Siega-Riz AM, Herring AH, Sjödin A, Daniels JL. 2016. Lactational exposure to polybrominated diphenyl ethers and its relation to early childhood anthropometric measurements. Environ Health Perspect 124:1656-1661; http://dx.doi.org/10.1289/EHP201.
Conflict of interest statement
The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official position of the National Cancer Institute or the CDC. The authors declare th
References
- Toxicol Sci. 2010 Jul;116(1):297-312 - PubMed
- Environ Health Perspect. 2012 Jul;120(7):1049-54 - PubMed
- Chemosphere. 2009 Jul;76(4):542-8 - PubMed
- Chemosphere. 2007 Apr;67(9):S307-17 - PubMed
- Toxicol Sci. 2009 Jan;107(1):27-39 - PubMed
- Environ Int. 2007 Feb;33(2):239-45 - PubMed
- Environ Health Perspect. 2009 Oct;117(10):1520-5 - PubMed
- Am J Epidemiol. 2011 Oct 15;174(8):885-92 - PubMed
- Toxicol Sci. 2004 Mar;78(1):144-55 - PubMed
- Environ Sci Technol. 2009 Oct 1;43(19):7490-5 - PubMed
- Environ Health Perspect. 2003 Jul;111(9):1249-52 - PubMed
- Environ Health Perspect. 2015 Jun;123(6):636-42 - PubMed
- J Environ Monit. 2007 Nov;9(11):1205-12 - PubMed
- Environ Health Perspect. 2016 Feb;124(2):220-7 - PubMed
- Int J Hyg Environ Health. 2009 Mar;212(2):109-34 - PubMed
- Environ Int. 2004 Jul;30(5):659-66 - PubMed
- Chem Res Toxicol. 2013 Nov 18;26(11):1692-702 - PubMed
- Vital Health Stat 11. 2002 May;(246):1-190 - PubMed
- Environ Sci Technol. 2004 Feb 15;38(4):945-56 - PubMed
- Chemosphere. 2009 Jan;74(3):428-33 - PubMed
- Environ Health Perspect. 2009 Sep;117(9):1461-5 - PubMed
- Environ Health Perspect. 2003 Nov;111(14):1723-9 - PubMed
- Toxicol Appl Pharmacol. 2006 Sep 1;215(2):135-45 - PubMed
- Chemosphere. 2007 Jun;68(5):797-803 - PubMed
- Environ Sci Technol. 2010 Jul 15;44(14):5627-32 - PubMed
- Anal Chem. 2004 Aug 1;76(15):4508-14 - PubMed
- J Toxicol Environ Health A. 2009;72(21-22):1296-303 - PubMed
- Environ Sci Technol. 2007 Mar 1;41(5):1584-9 - PubMed
- Toxicol Sci. 2001 May;61(1):76-82 - PubMed
- Toxicol Sci. 2002 Mar;66(1):105-16 - PubMed
- Environ Health Perspect. 2005 Jul;113(7):853-7 - PubMed
- J Toxicol Environ Health A. 2006 Aug;69(16):1541-54 - PubMed
- Toxicology. 2009 Jun 16;260(1-3):126-31 - PubMed
- Toxicol Appl Pharmacol. 2008 Feb 1;226(3):244-50 - PubMed
- Environ Sci Technol. 2008 May 1;42(9):3329-34 - PubMed
- Environ Health Perspect. 2001 Mar;109 Suppl 1:49-68 - PubMed
- Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jun;45(6):490-3 - PubMed
- Neurotoxicol Teratol. 2008 Mar-Apr;30(2):79-87 - PubMed
- Environ Int. 2003 Sep;29(6):829-39 - PubMed
- Environ Health Perspect. 2010 Jan;118(1):155-60 - PubMed
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