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Matsuba I, Sawa T, Kawata T, et al. Cross-National Variation in Glycemic Control and Diabetes-Related Distress Among East Asian Patients Using Insulin: Results from the MOSAIc Study. Diabetes Ther. 2016;7(2):349-60doi: 10.1007/s13300-016-0178-7.
Matsuba, I., Sawa, T., Kawata, T., Kanamori, A., Jiang, D., Machimura, H., Takeda, H., Han, J. H., Wang, K., Tanaka, K., Shen, L., Ajima, M., Kaneshiro, M., Kim, S. W., Umezawa, S., Asakura, T., Suzuki, S., & Kim, S. C. (2016). Cross-National Variation in Glycemic Control and Diabetes-Related Distress Among East Asian Patients Using Insulin: Results from the MOSAIc Study. Diabetes therapy : research, treatment and education of diabetes and related disorders, 7(2), 349-60. https://doi.org/10.1007/s13300-016-0178-7
Matsuba, Ikuro, et al. "Cross-National Variation in Glycemic Control and Diabetes-Related Distress Among East Asian Patients Using Insulin: Results from the MOSAIc Study." Diabetes therapy : research, treatment and education of diabetes and related disorders vol. 7,2 (2016): 349-60. doi: https://doi.org/10.1007/s13300-016-0178-7
Matsuba I, Sawa T, Kawata T, Kanamori A, Jiang D, Machimura H, Takeda H, Han JH, Wang K, Tanaka K, Shen L, Ajima M, Kaneshiro M, Kim SW, Umezawa S, Asakura T, Suzuki S, Kim SC. Cross-National Variation in Glycemic Control and Diabetes-Related Distress Among East Asian Patients Using Insulin: Results from the MOSAIc Study. Diabetes Ther. 2016 Jun;7(2):349-60. doi: 10.1007/s13300-016-0178-7. Epub 2016 Jun 02. PMID: 27255328; PMCID: PMC4900985.
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Diabetes Ther. 2016 Jun;7(2):349-60. doi: 10.1007/s13300-016-0178-7. Epub 2016 Jun 02.

Cross-National Variation in Glycemic Control and Diabetes-Related Distress Among East Asian Patients Using Insulin: Results from the MOSAIc Study.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Ikuro Matsuba, Tasuku Sawa, Takehiro Kawata, Akira Kanamori, Dingfeng Jiang, Hideo Machimura, Hiroshi Takeda, Jeong Hee Han, Ke Wang, Keiji Tanaka, Li Shen, Miho Ajima, Mizuki Kaneshiro, Sang-Wook Kim, Shinichi Umezawa, Taro Asakura, Shuichi Suzuki, Seoyoung C Kim

Affiliations

  1. The Study Group of the Diabetes Committee, Kanagawa Physicians Association, Kanagawa, Japan. [email protected].
  2. Department of Internal Medicine, Kawasaki Saiwai Hospital, Kanagawa, Japan.
  3. The Study Group of the Diabetes Committee, Kanagawa Physicians Association, Kanagawa, Japan.
  4. Eli Lilly & Company, Indianapolis, IN, USA.
  5. Lilly Korea Ltd, Seoul, Korea.
  6. Eli Lilly Suzhou Pharmaceutical Company, Shanghai, China.
  7. Department of Diabetology, Kawasaki Saiwai Clinic, Kanagawa, Japan.
  8. Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.
  9. Eli Lilly Japan K.K., Kobe, Japan.
  10. Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, USA.
  11. Harvard Medical School, Boston, MA, USA.

PMID: 27255328 PMCID: PMC4900985 DOI: 10.1007/s13300-016-0178-7

Abstract

INTRODUCTION: Guidelines recommend insulin progression for patients with type 2 diabetes (T2D) with inadequate glycemic control. The Multinational Observational Study Assessing Insulin use (MOSAIc [ClinicalTrials.gov identifier, NCT01400971]) study is a 2-year observational study, investigating factors that influence insulin progression in T2D patients. In this first of two reports, we describe baseline clinical and psychosocial characteristics of Chinese, Japanese, and South Korean patients who participated in MOSAIc. Insulin treatment, factors affecting progression, and outcomes will be reported separately.

METHODS: Patients with T2D using insulin for ≥3 months were eligible. Baseline demographic, clinical, and psychosocial data were collected from patients. Quality of life instruments, including the Diabetes Distress Scale (DDS), were used to assess patient's concerns about disease management, support, and emotional burden. The association between the DDS and the selected covariates was also assessed.

RESULTS: A total of 373 patients in China, 157 in Japan, and 141 in South Korea were enrolled from July 2011 to July 2013. Mean ± standard deviation duration (years) of T2D differed across countries (China 11.4 ± 7.5; Japan 13.8 ± 8.7; South Korea 15.7 ± 8.8; P < 0.0001). Japanese patients used more noninsulin anti-hyperglycemic agents than did Chinese or South Korean patients (P < 0.0001). Exclusive use of basal insulin was most common in Japan and South Korea compared with China, whereas approximately 66.8% of Chinese patients used mixed insulin. Covariates associated with the DDS were younger age [P = 0.044 (Japan)], higher incidence of monthly hypoglycemia [P = 0.036 [China]; P = 0.021 (South Korea)], and male gender [P = 0.037 (South Korea)].

CONCLUSIONS: There were significant differences amongst East Asian patients with T2D treated with insulin, including in quality of life scores. Results from the MOSAIc longitudinal analyses will further investigate trends of insulin intensification and barriers to insulin progression.

FUNDING: Eli Lilly and Company.

Keywords: Asia; Diabetes Mellitus; Hypoglycemia; Insulin; Patient-reported outcomes; Type 2

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