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Onwuka FC, Wuanyanwu KP, Nnodu CK, et al. Effect of amlodipine, a calcium channel antagonist, on gonadal steroid of male Wistar albino rats. J Exp Pharmacol. 2010;2:55-8
Onwuka, F. C., Wuanyanwu, K. P., Nnodu, C. K., & Erhabor, O. (2010). Effect of amlodipine, a calcium channel antagonist, on gonadal steroid of male Wistar albino rats. Journal of experimental pharmacology, 255-8.
Onwuka, F C, et al. "Effect of amlodipine, a calcium channel antagonist, on gonadal steroid of male Wistar albino rats." Journal of experimental pharmacology vol. 2 (2010): 55-8.
Onwuka FC, Wuanyanwu KP, Nnodu CK, Erhabor O. Effect of amlodipine, a calcium channel antagonist, on gonadal steroid of male Wistar albino rats. J Exp Pharmacol. 2010 Mar 13;2:55-8. eCollection 2010. PMID: 27186091; PMCID: PMC4863286.
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J Exp Pharmacol. 2010 Mar 13;2:55-8. eCollection 2010.

Effect of amlodipine, a calcium channel antagonist, on gonadal steroid of male Wistar albino rats.

Journal of experimental pharmacology

F C Onwuka, Kc Patrick-I Wuanyanwu, C K Nnodu, O Erhabor

Affiliations

  1. Department of Biochemistry, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria.
  2. Department of Haematology, College of Health Sciences, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria.

PMID: 27186091 PMCID: PMC4863286

Abstract

This study was carried out to investigate the effect of prolonged intake of calcium-channel blocker amlodipine, an antihypertensive drug on gonadal steroid hormone (testosterone) of male albino rats. Three different concentrations of amlodipine (0.01, 0.02 and 0.03 mg/kg body weight) was administered orally to three different groups (B, C, and D) of experimental male Wistar albino rats (n = 8) for six weeks. Group A rats were fed normal diet without amlodipine (n = 8) served as the control. The administration of amlodipine significantly reduced testosterone level in the following order, group A (0.22 ± 0.01) > B (0.18 ± 0.01) > C (0.14 ± 0.01) > D (0.10 ± 0.01). The reduction in testosterone levels corresponded with an increase in the concentration of amlodipine administered to male Wistar albino rats. The observation in this study reveals that long-term treatment of male Wistar rats with calcium-channel blocker and antihypertensive (amlodipine) produces a significant reduction in the level of testosterone a hormone associated with decreased ability of men to enjoy sex and to develop good quality erections. There is the need for a large scale study to investigate the potential effect of long-term antihypertensive therapy with amlodipine on sexual dysfunction in men.

Keywords: amlodipine; antihypertensive drugs; antireproductive; calcium-channel blocker; gonadal steroid; low libido

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