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Demir M, Tekgündüz E, Edis M, et al. Medikal hastalarda anti-heparin trombosit faktör 4 antikor ve heparine bağlı trombositopeni sıklığı. Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients. Turk J Haematol. 2009;26(4):171-5
Demir, M., Tekgündüz, E., Edis, M., Duran, E., Kürüm, T., Yiğitbaşı, �. �., & Yüksel, M. (2009). Medikal hastalarda anti-heparin trombosit faktör 4 antikor ve heparine bağlı trombositopeni sıklığı. Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients. Turkish journal of haematology : official journal of Turkish Society of Haematology, 26(4), 171-5.
Demir, Muzaffer, et al. "Medikal hastalarda anti-heparin trombosit faktör 4 antikor ve heparine bağlı trombositopeni sıklığı." Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients. Turkish journal of haematology : official journal of Turkish Society of Haematology vol. 26,4 (2009): 171-5.
Demir M, Tekgündüz E, Edis M, Duran E, Kürüm T, Yiğitbaşı Ö, Yüksel M. Medikal hastalarda anti-heparin trombosit faktör 4 antikor ve heparine bağlı trombositopeni sıklığı. Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients. Turk J Haematol. 2009 Dec 05;26(4):171-5. PMID: 27265628.
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Turk J Haematol. 2009 Dec 05;26(4):171-5.

Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients.

Turkish journal of haematology : official journal of Turkish Society of Haematology

Muzaffer Demir, Emre Tekgündüz, Mustafa Edis, Enver Duran, Turan Kürüm, Ömer Yiğitbaşı, Mahmut Yüksel

Affiliations

  1. Trakya University, School of Medicine, Division of Hematology, 22030 Edirne, Turkey, Phone: +90 284 235 76 42 - +90 284 235 10 41 E-mail: [email protected].

PMID: 27265628

Abstract

OBJECTIVE: Heparin-induced thrombocytopenia (HIT) is a life threatening complication of heparin therapy, causing thrombosis. The aim of our study was to find out the frequencies of HIT antibody seroconversion and clinical HIT in Turkish medical patients on different forms of heparins.

METHODS: Our study included 61 patients who were on unfractionated heparin (UFH) (n: 37) and low molecular weight heparin (LMWH) (n: 24) therapies. The frequency of HIT antibody formation was determined by means of antigenic (ELISA), and functional assays (serotonin release assay-SRA).

RESULTS: The seroconversion rates in UFH and LMWH groups were found to be 18.9% and 4.1% (ELISA), and 8.1% and 4.1% (SRA), respectively. One patient (2.1%) on UFH therapy developed deep vein thrombosis. No thromboembolic event was observed in patients taking LMWH.

CONCLUSION: Seroconversion rates by means of antigenic and functional assays and clinical HIT were more common in patients on UFH than patients on LMWH therapy.

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