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Kwon OJ, Kim MY, Shin SH, et al. Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats. Evid Based Complement Alternat Med. 2016;2016:2052180doi: 10.1155/2016/2052180.
Kwon, O. J., Kim, M. Y., Shin, S. H., Lee, A. R., Lee, J. Y., Seo, B. I., Shin, M. R., Choi, H. G., Kim, J. A., Min, B. S., Kim, G. N., Noh, J. S., Rhee, M. H., & Roh, S. S. (2016). Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats. Evidence-based complementary and alternative medicine : eCAM, 20162052180. https://doi.org/10.1155/2016/2052180
Kwon, O Jun, et al. "Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats." Evidence-based complementary and alternative medicine : eCAM vol. 2016 (2016): 2052180. doi: https://doi.org/10.1155/2016/2052180
Kwon OJ, Kim MY, Shin SH, Lee AR, Lee JY, Seo BI, Shin MR, Choi HG, Kim JA, Min BS, Kim GN, Noh JS, Rhee MH, Roh SS. Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats. Evid Based Complement Alternat Med. 2016;2016:2052180. doi: 10.1155/2016/2052180. Epub 2016 Apr 27. PMID: 27239206; PMCID: PMC4863117.
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Evid Based Complement Alternat Med. 2016;2016:2052180. doi: 10.1155/2016/2052180. Epub 2016 Apr 27.

Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats.

Evidence-based complementary and alternative medicine : eCAM

O Jun Kwon, Min Yeong Kim, Sung Ho Shin, Ah Reum Lee, Joo Young Lee, Bu-Il Seo, Mi-Rae Shin, Hyun Gyu Choi, Jeong Ah Kim, Byung Sun Min, Gyo-Nam Kim, Jeong Sook Noh, Man Hee Rhee, Seong-Soo Roh

Affiliations

  1. Kyeoungbuk Institute for Regional Program Evaluation, Gyeongbuk TP, 27 Sampoong-ro, Gyeongsan, Gyeongsangbuk-do 38542, Republic of Korea.
  2. College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea.
  3. College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
  4. College of Pharmacy, Catholic University of Daegu, Gyeongsangbuk-do 38430, Republic of Korea.
  5. Department of Food Science and Biotechnology, Kyungnam University, Gyeongsangnam-do 51767, Republic of Korea.
  6. Department of Food Science & Nutrition, Tongmyong University, Busan 48520, Republic of Korea.
  7. College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.

PMID: 27239206 PMCID: PMC4863117 DOI: 10.1155/2016/2052180

Abstract

The purpose of this study was to investigate the antioxidant and anti-inflammatory effects of the combined extract of Rhei rhizoma and Coptidis rhizoma (RC-mix) in experimental model of acute reflux esophagitis. The antioxidant activity was assessed by in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. RC-mix was given at 100, 200, and 400 mg/kg body weight 2 h prior to induction of reflux esophagitis (RE). After 5 h, the effects of RC-mix treated rats were compared with those of normal and control rats. The representative flavonoid contents of RC-mix, such as sennoside A, epiberberine, coptisine, palmatine, and berberine, were detected using HPLC. The elevated esophageal mucosa damage was markedly ameliorated by RC-mix treatment in a dose-dependent manner. Furthermore, the administration of RC-mix reduced the increase of serum reactive oxygen species (ROS) and peroxynitrite (ONOO(-)). The improvement of superoxide dismutase (SOD) and heme oxygenase-1 (HO-1) levels were marked in the group given RC-mix. Moreover, the elevation of inflammatory mediators and cytokines by nuclear factor-kappa B (NF-κB) activation in control rats decreased by RC-mix pretreatment. These results indicate that RC-mix treatment reduces the pathological states of esophagitis via regulating NF-κB mediated inflammation related to oxidative stress.

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