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Hunter LJ, Wood DM, Dargan PI. The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose. Open Access Emerg Med. 2011;3:39-48doi: 10.2147/OAEM.S22795.
Hunter, L. J., Wood, D. M., & Dargan, P. I. (2011). The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose. Open access emergency medicine : OAEM, 339-48. https://doi.org/10.2147/OAEM.S22795
Hunter, Laura J, et al. "The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose." Open access emergency medicine : OAEM vol. 3 (2011): 39-48. doi: https://doi.org/10.2147/OAEM.S22795
Hunter LJ, Wood DM, Dargan PI. The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose. Open Access Emerg Med. 2011 Jul 06;3:39-48. doi: 10.2147/OAEM.S22795. eCollection 2011. PMID: 27147851; PMCID: PMC4753966.
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Open Access Emerg Med. 2011 Jul 06;3:39-48. doi: 10.2147/OAEM.S22795. eCollection 2011.

The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose.

Open access emergency medicine : OAEM

Laura J Hunter, David M Wood, Paul I Dargan

Affiliations

  1. Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

PMID: 27147851 PMCID: PMC4753966 DOI: 10.2147/OAEM.S22795

Abstract

The nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, anti-inflammatory and antipyretic actions. They are commonly taken in overdose in many areas of the world. The majority of patients with acute NSAID overdose will remain asymptomatic or develop minor self-limiting gastrointestinal symptoms. However, serious clinical sequelae have been reported in patients with acute NSAID overdose and these include convulsions, metabolic acidosis, coma and acute renal failure. There appear to be some differences between the NSAIDs in terms of the relative risk of these complications; in particular mefenamic acid is most commonly associated with convulsions. The management of these serious clinical features is largely supportive and there are no specific antidotes for acute NSAID toxicity.

Keywords: ibuprofen; management; nonsteroidal anti-inflammatory drugs (NSAID); overdose; poisoning; toxicity

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