Display options
Cite
Stoddard RJ, Steger AL, Blakney AK, et al. In pursuit of functional electrospun materials for clinical applications in humans. Ther Deliv. 2016;7(6):387-409doi: 10.4155/tde-2016-0017.
Stoddard, R. J., Steger, A. L., Blakney, A. K., & Woodrow, K. A. (2016). In pursuit of functional electrospun materials for clinical applications in humans. Therapeutic delivery, 7(6), 387-409. https://doi.org/10.4155/tde-2016-0017
Stoddard, Ryan J, et al. "In pursuit of functional electrospun materials for clinical applications in humans." Therapeutic delivery vol. 7,6 (2016): 387-409. doi: https://doi.org/10.4155/tde-2016-0017
Stoddard RJ, Steger AL, Blakney AK, Woodrow KA. In pursuit of functional electrospun materials for clinical applications in humans. Ther Deliv. 2016 Jun;7(6):387-409. doi: 10.4155/tde-2016-0017. Epub 2016 Jun 02. PMID: 27250537; PMCID: PMC6077760.
Copy Download .nbib Format: NLM
Share it on

Ther Deliv. 2016 Jun;7(6):387-409. doi: 10.4155/tde-2016-0017. Epub 2016 Jun 02.

In pursuit of functional electrospun materials for clinical applications in humans.

Therapeutic delivery

Ryan J Stoddard, Arielle L Steger, Anna K Blakney, Kim A Woodrow

Affiliations

  1. University of Washington, Seattle, WA, 98195, USA.

PMID: 27250537 PMCID: PMC6077760 DOI: 10.4155/tde-2016-0017

Abstract

Electrospinning is a simple, low-cost and versatile approach to fabricate multifunctional materials useful in drug delivery and tissue engineering applications. Despite its emergence into other manufacturing sectors, electrospinning has not yet made a transformative impact in the clinic with a pharmaceutical product for use in humans. Why is this the current state of electrospun materials in biomedicine? Is it because electrospun materials are not yet capable of overcoming the biological safety and efficacy challenges needed in pharmaceutical products? Or, is it that technological advances in the electrospinning process are needed? This review investigates the current state of electrospun materials in medicine to identify both scientific and technological gaps that may limit clinical translation.

Keywords: clinical applications; drug delivery; electrospinning; medicated nanofibers; scale-up fabrication

References

  1. Adv Drug Deliv Rev. 2009 Oct 5;61(12):1033-42 - PubMed
  2. Int J Pharm. 2011 Apr 15;408(1-2):200-7 - PubMed
  3. Biomaterials. 2008 May;29(13):1989-2006 - PubMed
  4. J Pharm Sci. 2013 Feb;102(2):508-17 - PubMed
  5. Biomaterials. 2011 Feb;32(6):1583-90 - PubMed
  6. Adv Drug Deliv Rev. 2007 Dec 10;59(14):1413-33 - PubMed
  7. J Control Release. 2015 Sep 28;214:23-9 - PubMed
  8. Nat Commun. 2015 Apr 28;6:6933 - PubMed
  9. ACS Appl Mater Interfaces. 2012 Apr;4(4):1963-71 - PubMed
  10. J Biomater Appl. 2016 Jan;30(6):686-98 - PubMed
  11. Trials. 2006 May 15;7:14 - PubMed
  12. PLoS One. 2015 May 04;10(5):e0125407 - PubMed
  13. Antimicrob Agents Chemother. 2013 Aug;57(8):3928-35 - PubMed
  14. Colloids Surf B Biointerfaces. 2014 Sep 1;121:432-43 - PubMed
  15. Carbohydr Polym. 2013 Jan 2;91(1):434-43 - PubMed
  16. J Control Release. 2003 Oct 30;92(3):349-60 - PubMed
  17. PLoS One. 2015 Jul 29;10(7):e0134729 - PubMed
  18. Int J Pharm. 2007 Jun 29;338(1-2):276-83 - PubMed
  19. Macromol Biosci. 2011 Nov 10;11(11):1526-36 - PubMed
  20. PLoS One. 2012;7(11):e49792 - PubMed
  21. Colloids Surf B Biointerfaces. 2013 Oct 1;110:148-55 - PubMed
  22. J Biomater Sci Polym Ed. 2015;26(1):57-75 - PubMed
  23. J Pharm Sci. 2012 Jan;101(1):322-32 - PubMed
  24. Tissue Eng Part C Methods. 2011 Jul;17(7):705-15 - PubMed
  25. Carbohydr Polym. 2015 Dec 10;134:467-74 - PubMed
  26. Acta Biomater. 2010 Apr;6(4):1227-37 - PubMed
  27. Colloids Surf B Biointerfaces. 2013 Feb 1;102:737-43 - PubMed
  28. ACS Nano. 2015 Feb 24;9(2):1161-74 - PubMed
  29. Biomaterials. 2010 May;31(14):4113-20 - PubMed
  30. Dalton Trans. 2015 Feb 21;44(7):3118-27 - PubMed
  31. J Trauma. 2005 Jul;59(1):143-9 - PubMed
  32. Int J Nanomedicine. 2014 Jun 17;9:2967-78 - PubMed
  33. Trials. 2007 Sep 26;8:26 - PubMed
  34. Biomacromolecules. 2006 May;7(5):1623-9 - PubMed
  35. J Control Release. 2011 Dec 20;156(3):406-12 - PubMed
  36. Biomaterials. 2007 Apr;28(12):2087-96 - PubMed
  37. J Control Release. 2005 Nov 28;108(2-3):237-43 - PubMed
  38. Int J Pharm. 2012 Dec 15;439(1-2):296-306 - PubMed
  39. Biomaterials. 2015 Sep;64:70-7 - PubMed
  40. Macromol Biosci. 2011 Oct 10;11(10):1364-9 - PubMed
  41. J Mater Sci Mater Med. 2015 Jul;26(7):205 - PubMed
  42. Int J Pharm. 2014 Dec 30;477(1-2):369-79 - PubMed
  43. Acta Biomater. 2012 May;8(5):1901-7 - PubMed
  44. Adv Drug Deliv Rev. 2007 Dec 10;59(14):1392-412 - PubMed
  45. Biomacromolecules. 2006 Aug;7(8):2327-30 - PubMed
  46. Int J Pharm. 2014 Nov 20;475(1-2):282-91 - PubMed
  47. Int J Nanomedicine. 2012;7:763-71 - PubMed
  48. Eur J Pharm Biopharm. 2012 May;81(1):1-13 - PubMed
  49. Nano Lett. 2007 Jul;7(7):2122-8 - PubMed
  50. J Pharm Sci. 2010 Jul;99(7):2941-7 - PubMed
  51. Nat Commun. 2013;4:1633 - PubMed
  52. J Biomed Mater Res B Appl Biomater. 2014 Jul;102(5):977-87 - PubMed
  53. Expert Rev Med Devices. 2015;12(5):601-12 - PubMed
  54. Langmuir. 2013 Feb 19;29(7):2311-8 - PubMed
  55. J Control Release. 2010 Apr 19;143(2):175-82 - PubMed
  56. Langmuir. 2012 Jun 26;28(25):9714-21 - PubMed
  57. Biomaterials. 2005 May;26(15):2603-10 - PubMed
  58. Biomaterials. 2006 Jun;27(16):3115-24 - PubMed
  59. J Control Release. 2014 Nov 10;193:296-303 - PubMed
  60. Angew Chem Int Ed Engl. 2007;46(30):5670-703 - PubMed
  61. J Control Release. 2014 Jul 10;185:12-21 - PubMed
  62. Colloids Surf B Biointerfaces. 2008 Oct 15;66(2):206-12 - PubMed
  63. Biomaterials. 2012 Jan;33(2):524-34 - PubMed
  64. J Biomed Mater Res. 2002 Jun 15;60(4):613-21 - PubMed
  65. ACS Nano. 2015 Feb 24;9(2):1600-12 - PubMed
  66. Tissue Eng Part A. 2014 Jul;20(13-14):1935-47 - PubMed
  67. Acta Biomater. 2016 Apr 15;35:77-86 - PubMed
  68. Nanotechnology. 2009 Feb 4;20(5):055104 - PubMed
  69. J Vasc Access. 2013 Jul-Sep;14(3):252-6 - PubMed
  70. J Biomed Mater Res A. 2014 Mar;102(3):674-84 - PubMed
  71. Analyst. 2013 Apr 21;138(8):2215-23 - PubMed
  72. J Control Release. 2013 Aug 28;170(1):64-73 - PubMed
  73. Acta Biomater. 2010 Oct;6(10):4042-51 - PubMed
  74. Nano Lett. 2006 Dec;6(12):2868-72 - PubMed
  75. J Biomater Appl. 2015 Nov;30(5):512-25 - PubMed
  76. ACS Nano. 2015 Sep 22;9(9):9167-79 - PubMed
  77. Nanomedicine. 2015 Apr;11(3):693-704 - PubMed
  78. Int J Pharm. 2012 Nov 15;438(1-2):117-22 - PubMed
  79. Small. 2010 Aug 2;6(15):1612-6 - PubMed
  80. Adv Drug Deliv Rev. 2004 Feb 23;56(3):321-34 - PubMed
  81. Pharm Res. 2013 Jan;30(1):238-46 - PubMed
  82. J Biomed Mater Res B Appl Biomater. 2011 Apr;97(1):20-9 - PubMed
  83. Am J Trop Med Hyg. 2010 Jul;83(1):97-101 - PubMed
  84. AAPS PharmSciTech. 2013 Jun;14(2):569-77 - PubMed
  85. Int J Pharm. 2012 Apr 4;425(1-2):19-28 - PubMed
  86. Biomaterials. 2015 Jan;37:218-29 - PubMed
  87. J Control Release. 2012 Aug 10;161(3):903-9 - PubMed
  88. Chem Soc Rev. 2012 Jul 7;41(13):4708-35 - PubMed
  89. J Biomater Sci Polym Ed. 2013;24(8):972-85 - PubMed
  90. ACS Chem Neurosci. 2013 Sep 18;4(9):1314-21 - PubMed
  91. Biomacromolecules. 2008 Apr;9(4):1200-7 - PubMed
  92. J Vasc Access. 2011 Jan-Mar;12(1):28-35 - PubMed
  93. Acta Biomater. 2010 Nov;6(11):4199-207 - PubMed
  94. ACS Appl Mater Interfaces. 2015 Aug 26;7(33):18891-7 - PubMed
  95. Daru. 2014 Nov 18;22:73 - PubMed
  96. Exp Dermatol. 2012 Aug;21(8):619-24 - PubMed
  97. J Spec Oper Med. 2012 Summer;12(2):16-26 - PubMed
  98. Tissue Eng. 2006 May;12(5):1197-211 - PubMed

Substances

MeSH terms

Publication Types

Grant support