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Tanenbaum DG, Hall WA, Colbert LE, et al. TNFRSF10C copy number variation is associated with metastatic colorectal cancer. J Gastrointest Oncol. 2016;7(3):306-14doi: 10.21037/jgo.2015.11.04.
Tanenbaum, D. G., Hall, W. A., Colbert, L. E., Bastien, A. J., Brat, D. J., Kong, J., Kim, S., Dwivedi, B., Kowalski, J., Landry, J. C., & Yu, D. S. (2016). TNFRSF10C copy number variation is associated with metastatic colorectal cancer. Journal of gastrointestinal oncology, 7(3), 306-14. https://doi.org/10.21037/jgo.2015.11.04
Tanenbaum, Daniel G, et al. "TNFRSF10C copy number variation is associated with metastatic colorectal cancer." Journal of gastrointestinal oncology vol. 7,3 (2016): 306-14. doi: https://doi.org/10.21037/jgo.2015.11.04
Tanenbaum DG, Hall WA, Colbert LE, Bastien AJ, Brat DJ, Kong J, Kim S, Dwivedi B, Kowalski J, Landry JC, Yu DS. TNFRSF10C copy number variation is associated with metastatic colorectal cancer. J Gastrointest Oncol. 2016 Jun;7(3):306-14. doi: 10.21037/jgo.2015.11.04. PMID: 27284460; PMCID: PMC4880759.
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J Gastrointest Oncol. 2016 Jun;7(3):306-14. doi: 10.21037/jgo.2015.11.04.

TNFRSF10C copy number variation is associated with metastatic colorectal cancer.

Journal of gastrointestinal oncology

Daniel G Tanenbaum, William A Hall, Lauren E Colbert, Amanda J Bastien, Daniel J Brat, Jun Kong, Sungjin Kim, Bhakti Dwivedi, Jeanne Kowalski, Jerome C Landry, David S Yu

Affiliations

  1. 1 Department of Radiation Oncology, 2 Winship Cancer Institute, Emory University, GA, USA ; 3 Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA ; 4 Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA ; 5 Department of Pathology and Laboratory Medicine, 6 Department of Biomedical Informatics, 7 Department of Biostatistics and Bioinformatics, 8 Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

PMID: 27284460 PMCID: PMC4880759 DOI: 10.21037/jgo.2015.11.04

Abstract

BACKGROUND: Genetic markers for distant metastatic disease in patients with colorectal cancer (CRC) are not well defined. Identification of genetic alterations associated with metastatic CRC could help to guide systemic and local treatment strategies. We evaluated the association of tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) copy number variation (CNV) with distant metastatic disease in patients with CRC using The Cancer Genome Atlas (TCGA).

METHODS: Genetic sequencing data and clinical characteristics were obtained from TCGA for all available patients with CRC. There were 515 CRC patient samples with CNV and clinical outcome data, including a subset of 144 rectal adenocarcinoma patient samples. Using the TCGA CRC dataset, CNV of TNFRSF10C was evaluated for association with distant metastatic disease (M1 vs. M0). Multivariate logistic regression analysis with odds ratio (OR) using a 95% confidence interval (CI) was performed adjusting for age, T stage, N stage, adjuvant chemotherapy, gender, microsatellite instability (MSI), location, and surgical margin status.

RESULTS: TNFRSF10C CNV in patients with CRC was associated with distant metastatic disease [OR 4.81 (95% CI, 2.13-10.85) P<0.001] and positive lymph nodes [OR 18.83 (95% CI, 8.42-42.09)]; P<0.001) but not MSI (OR P=0.799). On multivariate analysis, after adjusting for pathologic T stage, N stage, adjuvant chemotherapy, gender, and MSI, TNFRSF10C CNV remained significantly associated with distant metastatic disease (OR P=0.018). Subset analysis revealed that TNFRSF10C CNV was also significantly associated with distant metastatic disease in patients with rectal adenocarcinoma (OR P=0.016).

CONCLUSIONS: TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. With further validation, such genetic profiles could be used clinically to support optimal systemic treatment strategies versus more aggressive local therapies in patients with CRC, including radiation therapy for rectal adenocarcinoma.

Keywords: Biomarker; colorectal cancer (CRC); copy number aberration; copy number variation (CNV); genetic marker; rectal cancer

References

  1. Med Oncol. 2013 Mar;30(1):371 - PubMed
  2. Nat Rev Cancer. 2004 Oct;4(10):769-80 - PubMed
  3. Clin Cancer Res. 2010 Mar 15;16(6):1701-8 - PubMed
  4. Int J Biochem Cell Biol. 2007;39(7-8):1462-75 - PubMed
  5. CA Cancer J Clin. 2014 Mar-Apr;64(2):104-17 - PubMed
  6. J Mol Med (Berl). 2009 Oct;87(10):995-1007 - PubMed
  7. Cancer. 2014 Jul 1;120(13):1948-59 - PubMed
  8. J Clin Oncol. 1997 Jan;15(1):85-93 - PubMed
  9. J Clin Oncol. 2006 Nov 1;24(31):4998-5004 - PubMed
  10. Clin Colorectal Cancer. 2013 Dec;12(4):248-54 - PubMed
  11. Nature. 2012 Jul 18;487(7407):330-7 - PubMed
  12. Clin Cancer Res. 2002 Dec;8(12 ):3734-40 - PubMed
  13. Prostate. 2009 Feb 15;69(3):327-35 - PubMed
  14. Semin Oncol. 2011 Aug;38(4):542-51 - PubMed
  15. J Neurooncol. 2006 Jun;78(2):161-71 - PubMed
  16. J Gastroenterol. 2006 Mar;41(3):185-92 - PubMed
  17. Eur J Cancer. 2005 Jan;41(2):272-9 - PubMed
  18. Int J Cancer. 2009 Nov 1;125(9):2127-35 - PubMed
  19. Nature. 2006 Nov 23;444(7118):444-54 - PubMed
  20. J Mol Diagn. 2006 May;8(2):193-201 - PubMed
  21. Br J Cancer. 2010 Feb 2;102(3):506-12 - PubMed
  22. PLoS One. 2014 Mar 05;9(3):e90459 - PubMed
  23. Clin Cancer Res. 2007 Jul 1;13(13):3831-9 - PubMed
  24. J Clin Oncol. 2012 Aug 20;30(24):2956-62 - PubMed
  25. Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4015-21 - PubMed
  26. N Engl J Med. 1997 Apr 3;336(14):980-7 - PubMed
  27. Eur J Cancer. 2008 Oct;44(15):2312-8 - PubMed
  28. PLoS One. 2014 Feb 05;9(2):e86833 - PubMed
  29. BMC Cancer. 2008 Jul 01;8:187 - PubMed
  30. Nat Rev Cancer. 2008 Oct;8(10):782-98 - PubMed
  31. Int J Cancer. 2004 May 1;109 (5):786-92 - PubMed
  32. Ann Oncol. 2014 Oct;25(10):1995-2001 - PubMed
  33. Genomics. 2014 Oct;104(4):234-41 - PubMed
  34. J Pathol. 2001 Sep;195(2):171-8 - PubMed
  35. Nat Rev Cancer. 2001 Oct;1(1):55-67 - PubMed
  36. BMC Med Genomics. 2013 Dec 05;6:54 - PubMed
  37. Oncogene. 1999 Jan 21;18(3):657-65 - PubMed
  38. Rev Recent Clin Trials. 2009 Jan;4(1):34-41 - PubMed

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