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Loverdos I, Swan MC, Shekherdimian S, et al. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep. 2015;3(5):223-226doi: 10.1016/j.epsc.2015.03.014.
Loverdos, I., Swan, M. C., Shekherdimian, S., Al-Rasheed, A. A., Schneider, R., Fish, J. S., Ngan, B. Y., Adeli, K., Lowe, M. E., Singh, V. P., Sevilla, W. M., Langer, J. C., & Gonska, T. (2015). A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. Journal of pediatric surgery case reports, 3(5), 223-226. https://doi.org/10.1016/j.epsc.2015.03.014
Loverdos, Ines, et al. "A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition." Journal of pediatric surgery case reports vol. 3,5 (2015): 223-226. doi: https://doi.org/10.1016/j.epsc.2015.03.014
Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, Ngan BY, Adeli K, Lowe ME, Singh VP, Sevilla WM, Langer JC, Gonska T. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep. 2015 May;3(5):223-226. doi: 10.1016/j.epsc.2015.03.014. PMID: 27182490; PMCID: PMC4864014.
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J Pediatr Surg Case Rep. 2015 May;3(5):223-226. doi: 10.1016/j.epsc.2015.03.014.

A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition.

Journal of pediatric surgery case reports

Ines Loverdos, Marc C Swan, Shant Shekherdimian, Abdulrahman A Al-Rasheed, Rayfel Schneider, Joel S Fish, Bo-Yee Ngan, Khosrow Adeli, Mark E Lowe, Vijay P Singh, Wednesday Marie A Sevilla, Jacob C Langer, Tanja Gonska

Affiliations

  1. Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  2. Division of Plastic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  3. Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  4. Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  5. Division of Pathology, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  6. Division of Clinical Biochemistry, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  7. Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  8. Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA.

PMID: 27182490 PMCID: PMC4864014 DOI: 10.1016/j.epsc.2015.03.014

Abstract

Pancreatitis-Panniculitis-Polyarthritis (PPP) syndrome is rare and its physiopathology unclear. A 6-year old boy suffered of traumatic pancreatitis complicated by PPP syndrome. Extensive investigations demonstrated high levels of pancreatic lipase and fatty acids in the affected peripheral tissues. These findings support the sequence of peripheral lipolysis and fatty acid accumulation inducing tissue inflammation.

Keywords: Complicated pancreatitis; Pancreatitis; Pediatric pancreatitis; panniculitis and polyarthritis syndrome

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