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A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition.

Journal of pediatric surgery case reports

Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, Ngan BY, Adeli K, Lowe ME, Singh VP, Sevilla WM, Langer JC, Gonska T.
PMID: 27182490
J Pediatr Surg Case Rep. 2015 May;3(5):223-226. doi: 10.1016/j.epsc.2015.03.014.

Pancreatitis-Panniculitis-Polyarthritis (PPP) syndrome is rare and its physiopathology unclear. A 6-year old boy suffered of traumatic pancreatitis complicated by PPP syndrome. Extensive investigations demonstrated high levels of pancreatic lipase and fatty acids in the affected peripheral tissues. These findings...

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Loverdos I, Swan MC, Shekherdimian S, et al. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep. 2015;3(5):223-226doi: 10.1016/j.epsc.2015.03.014.
Loverdos, I., Swan, M. C., Shekherdimian, S., Al-Rasheed, A. A., Schneider, R., Fish, J. S., Ngan, B. Y., Adeli, K., Lowe, M. E., Singh, V. P., Sevilla, W. M., Langer, J. C., & Gonska, T. (2015). A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. Journal of pediatric surgery case reports, 3(5), 223-226. https://doi.org/10.1016/j.epsc.2015.03.014
Loverdos, Ines, et al. "A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition." Journal of pediatric surgery case reports vol. 3,5 (2015): 223-226. doi: https://doi.org/10.1016/j.epsc.2015.03.014
Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, Ngan BY, Adeli K, Lowe ME, Singh VP, Sevilla WM, Langer JC, Gonska T. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep. 2015 May;3(5):223-226. doi: 10.1016/j.epsc.2015.03.014. PMID: 27182490; PMCID: PMC4864014.
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On the use of radiological protective gloves loaded with thorium oxide.

Comptes rendus des seances de la Societe de biologie et de ses filiales

LOVERDO A.
PMID: 18891701
C R Seances Soc Biol Fil. 1948 Jun;142(11):843.

No abstract available.

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LOVERDO A. Sur l'emploi de gants de protection radiologique chargès à l'oxyde de thorium. On the use of radiological protective gloves loaded with thorium oxide. C R Seances Soc Biol Fil. 1948;142(11):843
LOVERDO, A. (1948). Sur l'emploi de gants de protection radiologique chargès à l'oxyde de thorium. On the use of radiological protective gloves loaded with thorium oxide. Comptes rendus des seances de la Societe de biologie et de ses filiales, 142(11), 843.
LOVERDO, A. "Sur l'emploi de gants de protection radiologique chargès à l'oxyde de thorium." On the use of radiological protective gloves loaded with thorium oxide. Comptes rendus des seances de la Societe de biologie et de ses filiales vol. 142,11 (1948): 843.
LOVERDO A. Sur l'emploi de gants de protection radiologique chargès à l'oxyde de thorium. On the use of radiological protective gloves loaded with thorium oxide. C R Seances Soc Biol Fil. 1948 Jun;142(11):843. French. PMID: 18891701.
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Optimal reaction time for surface-mediated diffusion.

Physical review letters

Bénichou O, Grebenkov D, Levitz P, Loverdo C, Voituriez R.
PMID: 21230885
Phys Rev Lett. 2010 Oct 08;105(15):150606. doi: 10.1103/PhysRevLett.105.150606. Epub 2010 Oct 08.

We present an exact calculation of the mean first-passage time to a small target on the surface of a 2D or 3D spherical domain, for a molecule performing surface-mediated diffusion. This minimal model of interfacial reactions, which explicitly takes...

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Bénichou O, Grebenkov D, Levitz P, et al. Optimal reaction time for surface-mediated diffusion. Phys Rev Lett. 2010;105(15):150606doi: 10.1103/PhysRevLett.105.150606.
Bénichou, O., Grebenkov, D., Levitz, P., Loverdo, C., & Voituriez, R. (2010). Optimal reaction time for surface-mediated diffusion. Physical review letters, 105(15), 150606. https://doi.org/10.1103/PhysRevLett.105.150606
Bénichou, O, et al. "Optimal reaction time for surface-mediated diffusion." Physical review letters vol. 105,15 (2010): 150606. doi: https://doi.org/10.1103/PhysRevLett.105.150606
Bénichou O, Grebenkov D, Levitz P, Loverdo C, Voituriez R. Optimal reaction time for surface-mediated diffusion. Phys Rev Lett. 2010 Oct 08;105(15):150606. doi: 10.1103/PhysRevLett.105.150606. Epub 2010 Oct 08. PMID: 21230885.
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Eosinophilic pneumonia associated with daptomycin: a case report and a review of the literature.

Journal of medical case reports

Kalogeropoulos AS, Tsiodras S, Loverdos D, Fanourgiakis P, Skoutelis A.
PMID: 21241493
J Med Case Rep. 2011 Jan 17;5:13. doi: 10.1186/1752-1947-5-13.

INTRODUCTION: Although several studies did not demonstrate that daptomycin may cause significantly higher rates of pulmonary adverse effects when compared with vancomycin or penicillinase-resistant penicillins, there have been a few case reports of severe pulmonary complications associated with daptomycin...

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Kalogeropoulos AS, Tsiodras S, Loverdos D, et al. Eosinophilic pneumonia associated with daptomycin: a case report and a review of the literature. J Med Case Rep. 2011;5:13doi: 10.1186/1752-1947-5-13.
Kalogeropoulos, A. S., Tsiodras, S., Loverdos, D., Fanourgiakis, P., & Skoutelis, A. (2011). Eosinophilic pneumonia associated with daptomycin: a case report and a review of the literature. Journal of medical case reports, 513. https://doi.org/10.1186/1752-1947-5-13
Kalogeropoulos, Andreas S, et al. "Eosinophilic pneumonia associated with daptomycin: a case report and a review of the literature." Journal of medical case reports vol. 5 (2011): 13. doi: https://doi.org/10.1186/1752-1947-5-13
Kalogeropoulos AS, Tsiodras S, Loverdos D, Fanourgiakis P, Skoutelis A. Eosinophilic pneumonia associated with daptomycin: a case report and a review of the literature. J Med Case Rep. 2011 Jan 17;5:13. doi: 10.1186/1752-1947-5-13. PMID: 21241493; PMCID: PMC3033840.
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An identification and brief advice programme for low-risk alcohol consumption in an acute medical setting: an implementation study.

JRSM short reports

Woodrow SR, Green SA, Phekoo KJ, Grover VP, Lovendoski J, Anderson M, Bowden-Jones O, Foxton MR.
PMID: 23772314
JRSM Short Rep. 2013 Apr 18;4(5):2042533313476696. doi: 10.1177/2042533313476696. Print 2013 May.

OBJECTIVES: To implement an identification and brief advice (IBA) intervention to detect low-risk/hazardous alcohol consumption.DESIGN: Implementation was guided through the use of quality improvement tools and training.SETTING: This study was conducted over an 18-month period from April 2010 to...

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Woodrow SR, Green SA, Phekoo KJ, et al. An identification and brief advice programme for low-risk alcohol consumption in an acute medical setting: an implementation study. JRSM Short Rep. 2013;4(5):2042533313476696doi: 10.1177/2042533313476696.
Woodrow, S. R., Green, S. A., Phekoo, K. J., Grover, V. P., Lovendoski, J., Anderson, M., Bowden-Jones, O., & Foxton, M. R. (2013). An identification and brief advice programme for low-risk alcohol consumption in an acute medical setting: an implementation study. JRSM short reports, 4(5), 2042533313476696. https://doi.org/10.1177/2042533313476696
Woodrow, Susannah R, et al. "An identification and brief advice programme for low-risk alcohol consumption in an acute medical setting: an implementation study." JRSM short reports vol. 4,5 (2013): 2042533313476696. doi: https://doi.org/10.1177/2042533313476696
Woodrow SR, Green SA, Phekoo KJ, Grover VP, Lovendoski J, Anderson M, Bowden-Jones O, Foxton MR. An identification and brief advice programme for low-risk alcohol consumption in an acute medical setting: an implementation study. JRSM Short Rep. 2013 Apr 18;4(5):2042533313476696. doi: 10.1177/2042533313476696. Print 2013 May. PMID: 23772314; PMCID: PMC3681232.
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The Sequence of the Evil: A Case Report of Idiopathic Noncirrhotic Portal Hypertension Associated With Littoral Cell Angioma of the Spleen, 4 Years After the Successful Treatment of a Colon Cancer.

Journal of clinical and experimental hepatology

Fotis K, Christina L, Ioannis P, Angelos K, Dionysios L, Evangelos K.
PMID: 31024210
J Clin Exp Hepatol. 2019 Mar-Apr;9(2):273-276. doi: 10.1016/j.jceh.2018.08.004. Epub 2018 Aug 27.

Idiopathic noncirrhotic portal hypertension is a rare clinical entity. Even rarer is the littoral cell angioma of the spleen. The almost simultaneous appearance of the two disorders in a 64-year-old Greek woman was a tempting stimulus for us to...

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Fotis K, Christina L, Ioannis P, et al. The Sequence of the Evil: A Case Report of Idiopathic Noncirrhotic Portal Hypertension Associated With Littoral Cell Angioma of the Spleen, 4 Years After the Successful Treatment of a Colon Cancer. J Clin Exp Hepatol. 2018;9(2):273-276doi: 10.1016/j.jceh.2018.08.004.
Fotis, K., Christina, L., Ioannis, P., Angelos, K., Dionysios, L., & Evangelos, K. (2019). The Sequence of the Evil: A Case Report of Idiopathic Noncirrhotic Portal Hypertension Associated With Littoral Cell Angioma of the Spleen, 4 Years After the Successful Treatment of a Colon Cancer. Journal of clinical and experimental hepatology, 9(2), 273-276. https://doi.org/10.1016/j.jceh.2018.08.004
Fotis, Konstantinou, et al. "The Sequence of the Evil: A Case Report of Idiopathic Noncirrhotic Portal Hypertension Associated With Littoral Cell Angioma of the Spleen, 4 Years After the Successful Treatment of a Colon Cancer." Journal of clinical and experimental hepatology vol. 9,2 (2019): 273-276. doi: https://doi.org/10.1016/j.jceh.2018.08.004
Fotis K, Christina L, Ioannis P, Angelos K, Dionysios L, Evangelos K. The Sequence of the Evil: A Case Report of Idiopathic Noncirrhotic Portal Hypertension Associated With Littoral Cell Angioma of the Spleen, 4 Years After the Successful Treatment of a Colon Cancer. J Clin Exp Hepatol. 2019 Mar-Apr;9(2):273-276. doi: 10.1016/j.jceh.2018.08.004. Epub 2018 Aug 27. PMID: 31024210; PMCID: PMC6477133.
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Lung Microbiome in Asthma: Current Perspectives.

Journal of clinical medicine

Loverdos K, Bellos G, Kokolatou L, Vasileiadis I, Giamarellos E, Pecchiari M, Koulouris N, Koutsoukou A, Rovina N.
PMID: 31739446
J Clin Med. 2019 Nov 14;8(11). doi: 10.3390/jcm8111967.

A growing body of evidence implicates the human microbiome as a potentially influential player actively engaged in shaping the pathogenetic processes underlying the endotypes and phenotypes of chronic respiratory diseases, particularly of the airways. In this article, we specifically...

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Loverdos K, Bellos G, Kokolatou L, et al. Lung Microbiome in Asthma: Current Perspectives. J Clin Med. 2019;8(11)doi: 10.3390/jcm8111967.
Loverdos, K., Bellos, G., Kokolatou, L., Vasileiadis, I., Giamarellos, E., Pecchiari, M., Koulouris, N., Koutsoukou, A., & Rovina, N. (2019). Lung Microbiome in Asthma: Current Perspectives. Journal of clinical medicine, 8(11), . https://doi.org/10.3390/jcm8111967
Loverdos, Konstantinos, et al. "Lung Microbiome in Asthma: Current Perspectives." Journal of clinical medicine vol. 8,11 (2019). doi: https://doi.org/10.3390/jcm8111967
Loverdos K, Bellos G, Kokolatou L, Vasileiadis I, Giamarellos E, Pecchiari M, Koulouris N, Koutsoukou A, Rovina N. Lung Microbiome in Asthma: Current Perspectives. J Clin Med. 2019 Nov 14;8(11). doi: 10.3390/jcm8111967. PMID: 31739446; PMCID: PMC6912699.
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Case 2: Weight lost... and found.

Paediatrics & child health

McLaughlin T, Korenblum C, Loverdos I, Toulany A.
PMID: 25383005
Paediatr Child Health. 2014 Oct;19(8):e117-8. doi: 10.1093/pch/19.8.e118.

No abstract available.

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McLaughlin T, Korenblum C, Loverdos I, et al. Case 2: Weight lost... and found. Paediatr Child Health. 2014;19(8):e117-8doi: 10.1093/pch/19.8.e118.
McLaughlin, T., Korenblum, C., Loverdos, I., & Toulany, A. (2014). Case 2: Weight lost... and found. Paediatrics & child health, 19(8), e117-8. https://doi.org/10.1093/pch/19.8.e118
McLaughlin, Thomas, et al. "Case 2: Weight lost... and found." Paediatrics & child health vol. 19,8 (2014): e117-8. doi: https://doi.org/10.1093/pch/19.8.e118
McLaughlin T, Korenblum C, Loverdos I, Toulany A. Case 2: Weight lost... and found. Paediatr Child Health. 2014 Oct;19(8):e117-8. doi: 10.1093/pch/19.8.e118. PMID: 25383005; PMCID: PMC4220535.
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Evidence of anisotropic quenched disorder effects on a smectic liquid crystal confined in porous silicon.

Physical review. E, Statistical, nonlinear, and soft matter physics

Guégan R, Morineau D, Loverdo C, Béziel W, Guendouz M.
PMID: 16486169
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jan;73(1):011707. doi: 10.1103/PhysRevE.73.011707. Epub 2006 Jan 18.

We present a neutron scattering analysis of the structure of the smectic liquid crystal octylcyanobiphenyl (8CB) confined in one-dimensional nanopores of porous silicon films (PS). The smectic transition is completely suppressed, leading to the extension of a short-range ordered...

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Guégan R, Morineau D, Loverdo C, et al. Evidence of anisotropic quenched disorder effects on a smectic liquid crystal confined in porous silicon. Phys Rev E Stat Nonlin Soft Matter Phys. 2006;73(1):011707doi: 10.1103/PhysRevE.73.011707.
Guégan, R., Morineau, D., Loverdo, C., Béziel, W., & Guendouz, M. (2006). Evidence of anisotropic quenched disorder effects on a smectic liquid crystal confined in porous silicon. Physical review. E, Statistical, nonlinear, and soft matter physics, 73(1), 011707. https://doi.org/10.1103/PhysRevE.73.011707
Guégan, Régis, et al. "Evidence of anisotropic quenched disorder effects on a smectic liquid crystal confined in porous silicon." Physical review. E, Statistical, nonlinear, and soft matter physics vol. 73,1 (2006): 011707. doi: https://doi.org/10.1103/PhysRevE.73.011707
Guégan R, Morineau D, Loverdo C, Béziel W, Guendouz M. Evidence of anisotropic quenched disorder effects on a smectic liquid crystal confined in porous silicon. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jan;73(1):011707. doi: 10.1103/PhysRevE.73.011707. Epub 2006 Jan 18. PMID: 16486169.
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Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease.

Pharmaceutics

Salvador-Martín S, Kaczmarczyk B, Álvarez R, Navas-López VM, Gallego-Fernández C, Moreno-Álvarez A, Solar-Boga A, Sánchez C, Tolin M, Velasco M, Muñoz-Codoceo R, Rodriguez-Martinez A, Vayo CA, Bossacoma F, Pujol-Muncunill G, Fobelo MJ, Millán-Jiménez A, Magallares L, Martínez-Ojinaga E, Loverdos I, Eizaguirre FJ, Blanca-García JA, Clemente S, García-Romero R, Merino-Bohórquez V, González de Caldas R, Vázquez E, Dopazo A, Sanjurjo-Sáez M, López-Fernández LA.
PMID: 33429950
Pharmaceutics. 2021 Jan 08;13(1). doi: 10.3390/pharmaceutics13010077.

BACKGROUND: Up to 30% of patients with pediatric inflammatory bowel disease (IBD) do not respond to anti-Tumor Necrosis Factor (anti-TNF) therapy. The aim of this study was to identify pharmacogenomic markers that predict early response to anti-TNF drugs in...

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Salvador-Martín S, Kaczmarczyk B, Álvarez R, et al. Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease. Pharmaceutics. 2021;13(1)doi: 10.3390/pharmaceutics13010077.
Salvador-Martín, S., Kaczmarczyk, B., Álvarez, R., Navas-López, V. M., Gallego-Fernández, C., Moreno-Álvarez, A., Solar-Boga, A., Sánchez, C., Tolin, M., Velasco, M., Muñoz-Codoceo, R., Rodriguez-Martinez, A., Vayo, C. A., Bossacoma, F., Pujol-Muncunill, G., Fobelo, M. J., Millán-Jiménez, A., Magallares, L., Martínez-Ojinaga, E., Loverdos, I., Eizaguirre, F. J., Blanca-García, J. A., Clemente, S., García-Romero, R., Merino-Bohórquez, V., González de Caldas, R., Vázquez, E., Dopazo, A., Sanjurjo-Sáez, M., & López-Fernández, L. A. (2021). Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease. Pharmaceutics, 13(1), . https://doi.org/10.3390/pharmaceutics13010077
Salvador-Martín, Sara, et al. "Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease." Pharmaceutics vol. 13,1 (2021). doi: https://doi.org/10.3390/pharmaceutics13010077
Salvador-Martín S, Kaczmarczyk B, Álvarez R, Navas-López VM, Gallego-Fernández C, Moreno-Álvarez A, Solar-Boga A, Sánchez C, Tolin M, Velasco M, Muñoz-Codoceo R, Rodriguez-Martinez A, Vayo CA, Bossacoma F, Pujol-Muncunill G, Fobelo MJ, Millán-Jiménez A, Magallares L, Martínez-Ojinaga E, Loverdos I, Eizaguirre FJ, Blanca-García JA, Clemente S, García-Romero R, Merino-Bohórquez V, González de Caldas R, Vázquez E, Dopazo A, Sanjurjo-Sáez M, López-Fernández LA. Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease. Pharmaceutics. 2021 Jan 08;13(1). doi: 10.3390/pharmaceutics13010077. PMID: 33429950; PMCID: PMC7830359.
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mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion.

Human molecular genetics

Taylor H, Yerlioglu D, Phen C, Ballauff A, Nedelkopoulou N, Spier I, Loverdos I, Busoni VB, Heise J, Dale P, de Meij T, Sweet K, Cohen MC, Fox VL, Mas E, Aretz S, Eng C, Buderus S, Thomson M, Rojas I, Uhlig HH.
PMID: 33822054
Hum Mol Genet. 2021 Jun 26;30(14):1273-1282. doi: 10.1093/hmg/ddab094.

Ultra-rare genetic disorders can provide proof of concept for efficacy of targeted therapeutics and reveal pathogenic mechanisms relevant to more common conditions. Juvenile polyposis of infancy (JPI) is caused by microdeletions in chromosome 10 that result in haploinsufficiency of...

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Taylor H, Yerlioglu D, Phen C, et al. mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion. Hum Mol Genet. 2021;30(14):1273-1282doi: 10.1093/hmg/ddab094.
Taylor, H., Yerlioglu, D., Phen, C., Ballauff, A., Nedelkopoulou, N., Spier, I., Loverdos, I., Busoni, V. B., Heise, J., Dale, P., de Meij, T., Sweet, K., Cohen, M. C., Fox, V. L., Mas, E., Aretz, S., Eng, C., Buderus, S., Thomson, M., Rojas, I., & Uhlig, H. H. (2021). mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion. Human molecular genetics, 30(14), 1273-1282. https://doi.org/10.1093/hmg/ddab094
Taylor, Henry, et al. "mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion." Human molecular genetics vol. 30,14 (2021): 1273-1282. doi: https://doi.org/10.1093/hmg/ddab094
Taylor H, Yerlioglu D, Phen C, Ballauff A, Nedelkopoulou N, Spier I, Loverdos I, Busoni VB, Heise J, Dale P, de Meij T, Sweet K, Cohen MC, Fox VL, Mas E, Aretz S, Eng C, Buderus S, Thomson M, Rojas I, Uhlig HH. mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion. Hum Mol Genet. 2021 Jun 26;30(14):1273-1282. doi: 10.1093/hmg/ddab094. PMID: 33822054.
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Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis.

PLoS pathogens

Maier L, Diard M, Sellin ME, Chouffane ES, Trautwein-Weidner K, Periaswamy B, Slack E, Dolowschiak T, Stecher B, Loverdo C, Regoes RR, Hardt WD.
PMID: 26186334
PLoS Pathog. 2015 Jul 17;11(7):e1005047. doi: 10.1371/journal.ppat.1005047. eCollection 2015 Jul.

No abstract available.

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Maier L, Diard M, Sellin ME, et al. Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis. PLoS Pathog. 2015;11(7):e1005047doi: 10.1371/journal.ppat.1005047.
Maier, L., Diard, M., Sellin, M. E., Chouffane, E. S., Trautwein-Weidner, K., Periaswamy, B., Slack, E., Dolowschiak, T., Stecher, B., Loverdo, C., Regoes, R. R., & Hardt, W. D. (2015). Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis. PLoS pathogens, 11(7), e1005047. https://doi.org/10.1371/journal.ppat.1005047
Maier, Lisa, et al. "Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis." PLoS pathogens vol. 11,7 (2015): e1005047. doi: https://doi.org/10.1371/journal.ppat.1005047
Maier L, Diard M, Sellin ME, Chouffane ES, Trautwein-Weidner K, Periaswamy B, Slack E, Dolowschiak T, Stecher B, Loverdo C, Regoes RR, Hardt WD. Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis. PLoS Pathog. 2015 Jul 17;11(7):e1005047. doi: 10.1371/journal.ppat.1005047. eCollection 2015 Jul. PMID: 26186334; PMCID: PMC4506069.
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