Display options
Cite
Sim EK, Haider HKh, Lila N, et al. Genesis of myocardial repair with cardiac progenitor cells and tissue engineering. Heart Asia. 2010;2(1):109-11doi: 10.1136/ha.2009.001651.
Sim, E. K., Haider, H. K. h., Lila, N., Schussler, O., Chachques, J. C., & Ye, L. (2010). Genesis of myocardial repair with cardiac progenitor cells and tissue engineering. Heart Asia, 2(1), 109-11. https://doi.org/10.1136/ha.2009.001651
Sim, Eugene K W, et al. "Genesis of myocardial repair with cardiac progenitor cells and tissue engineering." Heart Asia vol. 2,1 (2010): 109-11. doi: https://doi.org/10.1136/ha.2009.001651
Sim EK, Haider HKh, Lila N, Schussler O, Chachques JC, Ye L. Genesis of myocardial repair with cardiac progenitor cells and tissue engineering. Heart Asia. 2010 Sep 18;2(1):109-11. doi: 10.1136/ha.2009.001651. eCollection 2010. PMID: 27325955; PMCID: PMC4898522.
Copy Download .nbib Format: NLM
Share it on

Heart Asia. 2010 Sep 18;2(1):109-11. doi: 10.1136/ha.2009.001651. eCollection 2010.

Genesis of myocardial repair with cardiac progenitor cells and tissue engineering.

Heart Asia

Eugene K W Sim, Husnain Kh Haider, Nermine Lila, Olivier Schussler, Juan C Chachques, Lei Ye

Affiliations

  1. Gleneagles JPMC Cardiac Centre, Brunei Darussalam & Mount Elizabeth Medical Centre, Singapore.
  2. Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  3. Laboratory of Biosurgical Research, Alain Carpentier Foundation, European Hospital Georges Pompidou, University Paris Descartes, Paris, France.
  4. Cardiovascular Research Institute, Department of Medicine, National University of Singapore, Singapore.

PMID: 27325955 PMCID: PMC4898522 DOI: 10.1136/ha.2009.001651

Abstract

BACKGROUND: There is mounting evidence to suggest that the heart has regenerative potential in the event of myocardial injury. Recent studies have shown that a resident population of cardiac progenitor cells (CPCs) in the heart contains both vasculogenic and myogenic lineages. CPCs are able to migrate to the site of injury in the heart for participation in the healing process. The resident CPCs in the heart may also be activated through outside pharmacological intervention to promote their participation in the intrinsic repair process. In the light of these characteristics, CPCs provide a logical source for the heart cell therapy. During the regenerative cardiac process, stem cell niches (a specialised environment surrounding stem cells) provide crucial support needed for their maintenance.

DISCUSSION: Compromised niche function may lead to the selection of stem cells that no longer depend on self-renewal factors produced by its environment. The objective of stem cell transplantation associated with tissue-engineered approaches is to create a new modality in the treatment of heart failure. The use of efficient scaffolds will aid to re-establish a favourable microenvironment for stem cell survival, multiplication, differentiation and function. Cardiac tissue engineering using natural and/or synthetic materials in this regard provides a novel possibility in cardiovascular therapeutics.

Keywords: Cardiac progenitor cell; angiogenesis; c-kit; cardiac repair; myogenesis; tissue characters; tissue engineering

References

  1. J Cell Biol. 2007 Jan 29;176(3):329-41 - PubMed
  2. J Thorac Cardiovasc Surg. 2004 Aug;128(2):245-53 - PubMed
  3. Circ Res. 2007 Mar 2;100(4):536-44 - PubMed
  4. Nature. 2004 Apr 8;428(6983):664-8 - PubMed
  5. Nat Med. 2006 Apr;12(4):459-65 - PubMed
  6. Exp Gerontol. 2005 Dec;40(12):926-30 - PubMed
  7. Aging Cell. 2008 Aug;7(4):590-8 - PubMed
  8. J Biotechnol. 2007 May 1;129(3):421-32 - PubMed
  9. Tissue Eng. 2007 Aug;13(8):1867-77 - PubMed
  10. J Heart Lung Transplant. 2008 Nov;27(11):1242-50 - PubMed
  11. Tissue Eng Part A. 2008 Mar;14(3):369-78 - PubMed
  12. J Mol Cell Cardiol. 2008 Oct;45(4):514-22 - PubMed
  13. Circ Res. 2005 Jan 7;96(1):127-37 - PubMed
  14. Biomaterials. 2008 May;29(13):2125-37 - PubMed
  15. Eur J Heart Fail. 2007 Jan;9(1):15-22 - PubMed
  16. Tissue Eng. 2006 Nov;12 (11):3233-45 - PubMed
  17. Ann Thorac Surg. 2008 Mar;85(3):901-8 - PubMed
  18. Biomaterials. 2005 Jun;26(16):3341-51 - PubMed
  19. Eur J Cardiothorac Surg. 2008 Aug;34(2):229-41 - PubMed
  20. Circulation. 2003 May 13;107(18):2294-302 - PubMed
  21. Tissue Eng. 2007 Nov;13(11):2681-7 - PubMed
  22. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8966-71 - PubMed
  23. J Am Coll Cardiol. 2003 Mar 5;41(5):879-88 - PubMed
  24. Circ Res. 2008 Jul 3;103(1):107-16 - PubMed
  25. Eur J Cardiothorac Surg. 2008 Aug;34(2):242-7 - PubMed
  26. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1668-73 - PubMed
  27. Nat Med. 2004 May;10(5):494-501 - PubMed
  28. Circulation. 2007 Feb 20;115(7):896-908 - PubMed
  29. Physiol Rev. 2005 Oct;85(4):1373-416 - PubMed
  30. Expert Rev Cardiovasc Ther. 2008 Jun;6(5):669-86 - PubMed
  31. Biomaterials. 2007 Dec;28(34):5033-43 - PubMed
  32. Biochem Biophys Res Commun. 2006 Mar 10;341(2):573-82 - PubMed
  33. Blood. 2007 Nov 1;110(9):3438-46 - PubMed
  34. J Mol Cell Cardiol. 2008 Oct;45(4):554-66 - PubMed
  35. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14068-73 - PubMed
  36. Circ Res. 2004 Oct 29;95(9):911-21 - PubMed
  37. Lancet. 2003 Feb 8;361(9356):491-2 - PubMed
  38. Cell Stem Cell. 2008 Dec 4;3(6):587-90 - PubMed
  39. Int J Cardiol. 2004 Jun;95 Suppl 1:S29-33 - PubMed
  40. Nature. 2001 Apr 5;410(6829):701-5 - PubMed
  41. Nat Med. 2006 Apr;12(4):452-8 - PubMed
  42. Circulation. 2007 Sep 11;116(11 Suppl):I113-20 - PubMed
  43. Heart Rhythm. 2006 Apr;3(4):452-61 - PubMed
  44. Expert Rev Cardiovasc Ther. 2009 Aug;7(8):911-9 - PubMed
  45. Circulation. 2006 Mar 21;113(11):1451-63 - PubMed
  46. J Am Coll Cardiol. 2006 Sep 5;48(5):907-13 - PubMed
  47. Int J Cardiol. 2010 Jan 21;138(2):131-7 - PubMed
  48. J Thorac Cardiovasc Surg. 2008 Apr;135(4):799-808 - PubMed
  49. Circulation. 2002 Oct 8;106(15):1913-8 - PubMed
  50. Tissue Eng. 2006 Mar;12(3):559-67 - PubMed

Publication Types