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Mukudai Y, Zhang M, Shiogama S, et al. Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma. Evid Based Complement Alternat Med. 2016;2016:6087213doi: 10.1155/2016/6087213.
Mukudai, Y., Zhang, M., Shiogama, S., Kondo, S., Ito, C., Motohashi, H., Kato, K., Fujii, M., Shintani, S., Shigemori, H., Yazawa, K., & Shirota, T. (2016). Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma. Evidence-based complementary and alternative medicine : eCAM, 20166087213. https://doi.org/10.1155/2016/6087213
Mukudai, Yoshiki, et al. "Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma." Evidence-based complementary and alternative medicine : eCAM vol. 2016 (2016): 6087213. doi: https://doi.org/10.1155/2016/6087213
Mukudai Y, Zhang M, Shiogama S, Kondo S, Ito C, Motohashi H, Kato K, Fujii M, Shintani S, Shigemori H, Yazawa K, Shirota T. Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma. Evid Based Complement Alternat Med. 2016;2016:6087213. doi: 10.1155/2016/6087213. Epub 2016 May 17. PMID: 27293462; PMCID: PMC4886073.
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Evid Based Complement Alternat Med. 2016;2016:6087213. doi: 10.1155/2016/6087213. Epub 2016 May 17.

Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma.

Evidence-based complementary and alternative medicine : eCAM

Yoshiki Mukudai, Meilin Zhang, Sunao Shiogama, Seiji Kondo, Chihiro Ito, Hiromi Motohashi, Kosuke Kato, Miharu Fujii, Satoru Shintani, Hideyuki Shigemori, Kazunaga Yazawa, Tatsuo Shirota

Affiliations

  1. Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, 2-1-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, Japan.
  2. Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
  3. Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
  4. Division of Health Food Science, Institute for Nanoscience and Nanotechnology, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-0041, Japan.

PMID: 27293462 PMCID: PMC4886073 DOI: 10.1155/2016/6087213

Abstract

Squamous cell carcinoma (SCC) is one of the most common cancers of the head and neck region worldwide and is generally treated surgically in combination with radiotherapy and/or chemotherapy. However, anticancer agents have numerous serious side effects, and alternative, less toxic agents that are effective as chemotherapeutics for SCC are required. The Paeoniaceae family is widely used in traditional Chinese medicine. We examined methanol and butanol extracts of Paeonia lutea (P. lutea) leaves for their potential as an anticancer agent. Both extracts decreased the proliferation of SCC cells, induced apoptotic cell death, and modulated migration, adhesion, chemotaxis, and haptotaxis in an extracellular matrix- (ECM-) dependent manner due to altered expression of several integrin subunits. Subsequently, SCC cells were subcutaneously transplanted into athymic nude mice; the extracts reduced the metastasis of SCC cells but had little effect on the volume of the primary tumor or survival or body weight of the mice. The results suggest that the extracts may hold promise for preventing cancer metastasis.

References

  1. Am J Chin Med. 2001;29(3-4):459-67 - PubMed
  2. Clin Exp Pharmacol Physiol. 2008 Feb;35(2):141-7 - PubMed
  3. Am J Chin Med. 2010;38(2):343-58 - PubMed
  4. Tohoku J Exp Med. 2009 Nov;219(3):177-86 - PubMed
  5. Int J Cancer. 2003 Nov 1;107(2):309-16 - PubMed
  6. Anticancer Res. 2012 Jul;32(7):2625-30 - PubMed
  7. J Ethnopharmacol. 2006 Jun 30;106(2):208-15 - PubMed
  8. Anticancer Res. 2011 Sep;31(9):2841-6 - PubMed
  9. Cell Oncol (Dordr). 2013 Jun;36(3):233-45 - PubMed
  10. Arch Toxicol. 2012 Aug;86(8):1233-50 - PubMed
  11. F1000Prime Rep. 2014 Jun 02;6:44 - PubMed
  12. Mol Med Rep. 2010 Jan-Feb;3(1):57-61 - PubMed
  13. Oral Oncol. 2006 Aug;42(7):675-84 - PubMed
  14. Br J Pharmacol. 2003 Jul;139(6):1146-52 - PubMed
  15. J Nutr Sci Vitaminol (Tokyo). 2012;58(2):129-35 - PubMed
  16. Evid Based Complement Alternat Med. 2012;2012:409823 - PubMed
  17. J Neurochem. 2009 Jun;109(6):1648-57 - PubMed
  18. Mol Cancer Ther. 2009 Jan;8(1):10-6 - PubMed
  19. J Biomed Sci. 2012 Sep 10;19:82 - PubMed
  20. Life Sci. 2001 Feb 23;68(14):1687-94 - PubMed
  21. Evid Based Complement Alternat Med. 2013;2013:207279 - PubMed
  22. Biochim Biophys Acta. 2011 Jun;1807(6):735-45 - PubMed
  23. Biol Pharm Bull. 2012;35(8):1264-8 - PubMed
  24. Phytomedicine. 2007 Nov;14(11):778-84 - PubMed
  25. Biochim Biophys Acta. 2013 Dec;1833(12):3481-98 - PubMed
  26. Oral Oncol. 2011 May;47(5):334-9 - PubMed
  27. J Pharm Pharmacol. 2012 Mar;64(3):420-9 - PubMed
  28. Cancer Metastasis Rev. 2010 Mar;29(1):223-37 - PubMed
  29. Arch Pharm Res. 2004 Nov;27(11):1123-6 - PubMed
  30. BMC Complement Altern Med. 2014 Jan 17;14:29 - PubMed
  31. Nat Clin Pract Oncol. 2008 Jan;5(1):32-43 - PubMed
  32. Brain Res. 2011 May 4;1388:141-7 - PubMed
  33. J Clin Oncol. 2004 Aug 1;22(15):3061-9 - PubMed
  34. Anticancer Res. 2013 Oct;33(10 ):4309-17 - PubMed
  35. J Nutr Sci Vitaminol (Tokyo). 2012;58(1):63-7 - PubMed
  36. J Cancer Res Clin Oncol. 1996;122(4):243-8 - PubMed
  37. Mol Clin Oncol. 2013 Jan;1(1):105-111 - PubMed
  38. J Oral Maxillofac Surg. 2003 Jun;61(6):696-700 - PubMed
  39. Curr Opin Cell Biol. 2009 Dec;21(6):871-7 - PubMed
  40. Oncol Rep. 2013 Dec;30(6):2665-71 - PubMed

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