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Gan L, Feng C, Liu C, et al. Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography. Exp Ther Med. 2016;12(2):667-675doi: 10.3892/etm.2016.3371.
Gan, L., Feng, C., Liu, C., Tian, S., Song, X., & Yang, L. (2016). Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography. Experimental and therapeutic medicine, 12(2), 667-675. https://doi.org/10.3892/etm.2016.3371
Gan, Lu, et al. "Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography." Experimental and therapeutic medicine vol. 12,2 (2016): 667-675. doi: https://doi.org/10.3892/etm.2016.3371
Gan L, Feng C, Liu C, Tian S, Song X, Yang L. Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography. Exp Ther Med. 2016 Aug;12(2):667-675. doi: 10.3892/etm.2016.3371. Epub 2016 May 19. PMID: 27446259; PMCID: PMC4950222.
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Exp Ther Med. 2016 Aug;12(2):667-675. doi: 10.3892/etm.2016.3371. Epub 2016 May 19.

Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography.

Experimental and therapeutic medicine

Lu Gan, Cong Feng, Chunlei Liu, Shuping Tian, Xiang Song, Li Yang

Affiliations

  1. Department of Radiology, General Hospital of the PLA, Beijing 100853, P.R. China.
  2. Department of Emergency, General Hospital of the PLA, Beijing 100853, P.R. China.
  3. The PLA Medical College, General Hospital of the PLA, Beijing 100853, P.R. China.

PMID: 27446259 PMCID: PMC4950222 DOI: 10.3892/etm.2016.3371

Abstract

The aim of the present study was to explore the association between the levels of serum N-terminal pro-B-type natriuretic peptide (NT-pro BNP) and the characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography (CCTA), in patients with unstable angina (UA). A total of 202 patients (age range, 47-82 years) were divided into the following three groups: Non-cardiac disease group (57 patients); stable angina pectoris (SAP) group (62 patients); and UA group (83 patients). There were significant differences between the serum NT-pro BNP levels among the three groups (P=0.007). However, in multivariant diagnoses, NT-pro BNP level was not an independent risk factor for UA. The levels of serum NT-pro BNP were observed to be positively correlated with the number of vessels involved (r=0.462; P<0.001), SIS (r=0.475; P<0.001), segment-stenosis score (r=0.453; P<0.001), coronary calcification score (r=0.412; P=0.001), number of obstructive diseases (r=0.346; P<0.001), and the number of segments with non-calcified plaque (r=0.235; P=0.017), mixed plaque (r=0.234; P=0.017) and calcified plaque (r=0.431; P<0.001). The levels of serum NT-pro BNP were significantly higher in patients with UA and left main-left anterior descending (LM-LAD) disease, compared with UA patients without LM-LAD disease (P<0.001). In addition, serum NT-pro BNP was significantly higher in patients with obstructive disease and UA than in those without obstructive disease (P<0.001). The area under the curve of log(NT-pro BNP) was 0.656 (P=0.006; optimal cut-off value, 1.74; sensitivity, 77.6%; specificity, 51.9%). In conclusion, the levels of serum NT-pro BNP are associated with the burden and severity of coronary artery atherosclerotic disease in patients with UA, and may be helpful in risk stratification of patients with UA.

Keywords: N-terminal pro-B-type natriuretic peptide; coronary atherosclerotic plaque; unstable angina

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