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Viruses. 2016 Sep 19;8(9). doi: 10.3390/v8090259.

Markers for Ongoing or Previous Hepatitis E Virus Infection Are as Common in Wild Ungulates as in Humans in Sweden.

Viruses

Anette Roth, Jay Lin, Lars Magnius, Marie Karlsson, Sándór Belák, Frederik Widén, Heléne Norder

Affiliations

  1. Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 46 Gothenburg, Sweden. [email protected].
  2. Department of Virology, Microbiology, National Veterinary Institute, 756 51 Uppsala, Sweden. [email protected].
  3. Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), 756 51 Uppsala, Sweden. [email protected].
  4. The OIE (World Organisation for Animal Health) Collaborating Centre for the Biotechnology-Based Diagnosis of Infectious Diseases in Veterinary Medicine, 756 51 Uppsala, Sweden. [email protected].
  5. Ulf Lundahl Foundation, 116 21 Stockholm, Sweden. [email protected].
  6. Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 46 Gothenburg, Sweden. [email protected].
  7. Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), 756 51 Uppsala, Sweden. [email protected].
  8. The OIE (World Organisation for Animal Health) Collaborating Centre for the Biotechnology-Based Diagnosis of Infectious Diseases in Veterinary Medicine, 756 51 Uppsala, Sweden. [email protected].
  9. Department of Virology, Microbiology, National Veterinary Institute, 756 51 Uppsala, Sweden. [email protected].
  10. Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), 756 51 Uppsala, Sweden. [email protected].
  11. The OIE (World Organisation for Animal Health) Collaborating Centre for the Biotechnology-Based Diagnosis of Infectious Diseases in Veterinary Medicine, 756 51 Uppsala, Sweden. [email protected].
  12. Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 46 Gothenburg, Sweden. [email protected].

PMID: 27657108 PMCID: PMC5035973 DOI: 10.3390/v8090259

Abstract

Hepatitis E virus (HEV) is a human pathogen with zoonotic spread, infecting both domestic and wild animals. About 17% of the Swedish population is immune to HEV, but few cases are reported annually, indicating that most infections are subclinical. However, clinical hepatitis E may also be overlooked. For identified cases, the source of infection is mostly unknown. In order to identify whether HEV may be spread from wild game, the prevalence of markers for past and/or ongoing infection was investigated in sera and stool samples collected from 260 hunted Swedish wild ungulates. HEV markers were found in 43 (17%) of the animals. The most commonly infected animal was moose (

Keywords: Sweden; deer; hepatitis E virus; moose; phylogenetic analysis; wild animals; wild boar; zoonosis

Conflict of interest statement

The authors declare no conflict of interest.

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