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Lin C, Chen HC, Fang WH, et al. Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis. PLoS One. 2016;11(9):e0161754doi: 10.1371/journal.pone.0161754.
Lin, C., Chen, H. C., Fang, W. H., Wang, C. C., Peng, Y. J., Lee, H. S., Chang, H., Chu, C. M., Huang, G. S., Chen, W. T., Tsai, Y. J., Lin, H. L., Lin, F. H., & Su, S. L. (2016). Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis. PloS one, 11(9), e0161754. https://doi.org/10.1371/journal.pone.0161754
Lin, Chin, et al. "Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis." PloS one vol. 11,9 (2016): e0161754. doi: https://doi.org/10.1371/journal.pone.0161754
Lin C, Chen HC, Fang WH, Wang CC, Peng YJ, Lee HS, Chang H, Chu CM, Huang GS, Chen WT, Tsai YJ, Lin HL, Lin FH, Su SL. Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis. PLoS One. 2016 Sep 22;11(9):e0161754. doi: 10.1371/journal.pone.0161754. eCollection 2016. PMID: 27657933; PMCID: PMC5033346.
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PLoS One. 2016 Sep 22;11(9):e0161754. doi: 10.1371/journal.pone.0161754. eCollection 2016.

Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis.

PloS one

Chin Lin, Hsiang-Cheng Chen, Wen-Hui Fang, Chih-Chien Wang, Yi-Jen Peng, Herng-Sheng Lee, Hung Chang, Chi-Ming Chu, Guo-Shu Huang, Wei-Teing Chen, Yu-Jui Tsai, Hong-Ling Lin, Fu-Huang Lin, Sui-Lung Su

Affiliations

  1. School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
  2. Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  3. Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  4. Department of Orthopedics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  5. Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  6. Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
  7. Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan?, ROC.
  8. Division of Thoracic Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  9. Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  10. Department of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan, ROC.
  11. Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

PMID: 27657933 PMCID: PMC5033346 DOI: 10.1371/journal.pone.0161754

Abstract

BACKGROUND: Studies of angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms and the risks of knee osteoarthritis (OA) have yielded conflicting results.

OBJECTIVE: To determine the association between ACE I/D and knee OA, we conducted a combined case-control study and meta-analysis.

METHODS: For the case-control study, 447 knee OA cases and 423 healthy controls were recruited between March 2010 and July 2011. Knee OA cases were defined using the Kellgren-Lawrence grading system, and the ACE I/D genotype was determined using a standard polymerase chain reaction. The association between ACE I/D and knee OA was detected using allele, genotype, dominant, and recessive models. For the meta-analysis, PubMed and Embase databases were systematically searched for prospective observational studies published up until August 2015. Studies of ACE I/D and knee OA with sufficient data were selected. Pooled results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) for the D versus I allele with regard to knee OA risk.

RESULTS: We found no significant association between the D allele and knee OA [OR: 1.09 (95% CI: 0.76-1.89)] in the present case-control study, and the results of other genetic models were also nonsignificant. Five current studies were included, and there were a total of six study populations after including our case-control study (1165 cases and 1029 controls). In the meta-analysis, the allele model also yielded nonsignificant results [OR: 1.37 (95% CI: 0.95-1.99)] and a high heterogeneity (I2: 87.2%).

CONCLUSIONS: The association between ACE I/D and knee OA tended to yield negative results. High heterogeneity suggests a complex, multifactorial mechanism, and an epistasis analysis of ACE I/D and knee OA should therefore be conducted.

Conflict of interest statement

The authors have declared that no competing interests exist.

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