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Park SY, Burton D, Busciglio I, et al. Regional Colonic Transit Pattern Does Not Conclusively Identify Evacuation Disorders in Constipated Patients with Delayed Colonic Transit. J Neurogastroenterol Motil. 2017;23(1):92-100doi: 10.5056/jnm16066.
Park, S. Y., Burton, D., Busciglio, I., Eckert, D., & Camilleri, M. (2017). Regional Colonic Transit Pattern Does Not Conclusively Identify Evacuation Disorders in Constipated Patients with Delayed Colonic Transit. Journal of neurogastroenterology and motility, 23(1), 92-100. https://doi.org/10.5056/jnm16066
Park, Seon-Young, et al. "Regional Colonic Transit Pattern Does Not Conclusively Identify Evacuation Disorders in Constipated Patients with Delayed Colonic Transit." Journal of neurogastroenterology and motility vol. 23,1 (2017): 92-100. doi: https://doi.org/10.5056/jnm16066
Park SY, Burton D, Busciglio I, Eckert D, Camilleri M. Regional Colonic Transit Pattern Does Not Conclusively Identify Evacuation Disorders in Constipated Patients with Delayed Colonic Transit. J Neurogastroenterol Motil. 2017 Jan 30;23(1):92-100. doi: 10.5056/jnm16066. PMID: 27667753; PMCID: PMC5216639.
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J Neurogastroenterol Motil. 2017 Jan 30;23(1):92-100. doi: 10.5056/jnm16066.

Regional Colonic Transit Pattern Does Not Conclusively Identify Evacuation Disorders in Constipated Patients with Delayed Colonic Transit.

Journal of neurogastroenterology and motility

Seon-Young Park, Duane Burton, Irene Busciglio, Deborah Eckert, Michael Camilleri

Affiliations

  1. Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

PMID: 27667753 PMCID: PMC5216639 DOI: 10.5056/jnm16066

Abstract

BACKGROUND/AIMS: After exclusion of structural diseases, chronic constipation may be associated with normal or slow transit or rectal evacuation disorders. We evaluated: (1) clinical features and anorectal function, (2) difference of regional colonic transit according to the presence or absence of evacuation disorders, and (3) association of colonic transit with gender in patients with objectively slow colonic transit.

METHODS: We reviewed electronic medical records of 1553 patients with constipation seen by one gastroenterologist from 1994-2015 at a tertiary medical center. We identified patients with slow colonic transit using scintigraphy. Evacuation disorders were identified on clinical examination or anorectal manometry. Colonic compliance and tone were measured in 29 patients. Statistical analysis was by the Mann-Whitney rank sum test.

RESULTS: Of the 207 patients (155 females, mean age 41.3 ± 15.3 [SD] years), 113 had evacuation disorders (ED+ve) and 94 did not (ED-ve). There were no significant differences in colonic transit or gastric emptying between ED+ve or ED-ve; similarly, colonic compliance, tone and responses to neostigmine were not different in ED+ve and ED-ve. Conversely, there were significant differences by gender in patients with slow colonic transit: colonic transit, small bowel transit, and gastric emptying (all

CONCLUSIONS: Delayed colonic transit does not exclude evacuation disorders in chronic constipation. In chronic constipation and objectively slow colonic transit, females had slower gastric, small bowel, and colonic transit than males.

Keywords: Colon; Constipation; Gastric emptying; Gastrointestinal transit; Rectal disease

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