Display options
Cite
Ridgeway ME, Wolff JJ, Silveira JA, et al. Gated Trapped Ion Mobility Spectrometry Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Int J Ion Mobil Spectrom. 2016;19(2):77-85doi: 10.1007/s12127-016-0197-0.
Ridgeway, M. E., Wolff, J. J., Silveira, J. A., Lin, C., Costello, C. E., & Park, M. A. (2016). Gated Trapped Ion Mobility Spectrometry Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry, 19(2), 77-85. https://doi.org/10.1007/s12127-016-0197-0
Ridgeway, Mark E, et al. "Gated Trapped Ion Mobility Spectrometry Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry." International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry vol. 19,2 (2016): 77-85. doi: https://doi.org/10.1007/s12127-016-0197-0
Ridgeway ME, Wolff JJ, Silveira JA, Lin C, Costello CE, Park MA. Gated Trapped Ion Mobility Spectrometry Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Int J Ion Mobil Spectrom. 2016 Sep;19(2):77-85. doi: 10.1007/s12127-016-0197-0. Epub 2016 Mar 29. PMID: 27667964; PMCID: PMC5029861.
Copy Download .nbib Format: NLM
Share it on

Int J Ion Mobil Spectrom. 2016 Sep;19(2):77-85. doi: 10.1007/s12127-016-0197-0. Epub 2016 Mar 29.

Gated Trapped Ion Mobility Spectrometry Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry

Mark E Ridgeway, Jeremy J Wolff, Joshua A Silveira, Cheng Lin, Catherine E Costello, Melvin A Park

Affiliations

  1. Bruker Daltonics, 40 Manning Rd, Billerica, MA 01821.
  2. Mass Spectrometry Resource, Department of Biochemistry, Boston University School of Medicine, 670 Albany Street, Suite 504, Boston, MA 02118.

PMID: 27667964 PMCID: PMC5029861 DOI: 10.1007/s12127-016-0197-0

Abstract

Analysis of molecules by ion mobility spectrometry coupled with mass spectrometry (IMS-MS) provides chemical information on the three dimensional structure and mass of the molecules. The coupling of ion mobility to trapping mass spectrometers has historically been challenging due to the large differences in analysis time between the two devices. In this paper we present a modification of the trapped ion mobility (TIMS) analysis scheme termed "Gated TIMS" that allows efficient coupling to a Fourier Transform Ion Cyclotron Resonance (FT-ICR) analyzer. Analyses of standard compounds and the influence of source conditions on the TIMS distributions produced by ion mobility spectra of labile ubiquitin protein ions are presented. Ion mobility resolving powers up to 100 are observed. Measured collisional cross sections of ubiquitin ions are in excellent qualitative and quantitative agreement to previous measurements. Gated TIMS FT-ICR produces results comparable to those acquired using TIMS/time-of-flight MS instrument platforms as well as numerous drift tube IMS-MS studies published in the literature.

References

  1. Anal Chem. 2008 Dec 1;80(23):9073-83 - PubMed
  2. J Proteome Res. 2015 Dec 4;14(12):5378-87 - PubMed
  3. J Phys Chem Lett. 2014 Jun 5;5(11):1825-30 - PubMed
  4. J Am Chem Soc. 2011 Sep 7;133(35):13810-3 - PubMed
  5. Nat Chem. 2009 Jul;1(4):326-31 - PubMed
  6. Rapid Commun Mass Spectrom. 2007;21(7):1115-22 - PubMed
  7. J Am Soc Mass Spectrom. 2007 Jul;18(7):1249-64 - PubMed
  8. J Am Soc Mass Spectrom. 2011 Sep;22(9):1477-85 - PubMed
  9. J Am Soc Mass Spectrom. 2016 Apr;27(4):585-95 - PubMed
  10. Nat Chem. 2011 Feb;3(2):126-32 - PubMed
  11. J Am Soc Mass Spectrom. 2014 Dec;25(12):2020-7 - PubMed
  12. Science. 2005 Dec 9;310(5754):1658-61 - PubMed
  13. J Am Soc Mass Spectrom. 2012 Jul;23(7):1173-81 - PubMed
  14. Anal Chem. 2014 Jun 17;86(12):5624-7 - PubMed
  15. Int J Ion Mobil Spectrom. 2015 Oct;18(3):151-157 - PubMed
  16. J Am Soc Mass Spectrom. 2015 Jan;26(1):14-24 - PubMed
  17. Analyst. 2014 Apr 21;139(8):1913-21 - PubMed
  18. J Am Chem Soc. 2012 Feb 22;134(7):3429-38 - PubMed
  19. Anal Chem. 2013 Apr 2;85(7):3651-9 - PubMed
  20. J Am Soc Mass Spectrom. 2000 Aug;11(8):738-45 - PubMed
  21. J Am Soc Mass Spectrom. 2012 Mar;23(3):553-62 - PubMed
  22. J Am Chem Soc. 2013 Nov 13;135(45):16926-37 - PubMed
  23. Nat Chem. 2011 Feb;3(2):172-7 - PubMed
  24. J Am Chem Soc. 2013 Dec 26;135(51):19147-53 - PubMed
  25. Anal Chem. 2014 Aug 19;86(16):8121-8 - PubMed
  26. Anal Chem. 2005 May 15;77(10):3330-9 - PubMed
  27. J Mol Biol. 2013 Nov 29;425(23):4790-801 - PubMed
  28. Anal Chem. 2013 Dec 17;85(24):12055-61 - PubMed
  29. Anal Chem. 2014 Feb 18;86(4):2019-24 - PubMed
  30. Talanta. 2001 May 10;54(3):515-29 - PubMed
  31. Anal Chem. 2014 May 6;86(9):4362-70 - PubMed
  32. J Phys Chem B. 2011 Oct 27;115(42):12266-75 - PubMed
  33. Int J Ion Mobil Spectrom. 2011 Sep;14(2-3):null - PubMed
  34. Analyst. 2015 Oct 21;140(20):6862-70 - PubMed
  35. J Am Soc Mass Spectrom. 2002 May;13(5):499-505 - PubMed
  36. Phys Rev Lett. 1994 Oct 10;73(15):2063-2066 - PubMed
  37. J Am Chem Soc. 2013 Feb 27;135(8):3186-92 - PubMed
  38. Science. 1995 Mar 10;267(5203):1483-5 - PubMed
  39. Anal Chem. 2013 Aug 20;85(16):7826-33 - PubMed
  40. Anal Chem. 2009 Dec 15;81(24):9941-7 - PubMed
  41. Anal Chem. 2015 Apr 21;87(8):4321-5 - PubMed
  42. Analyst. 2016 Jun 7;141(12):3722-30 - PubMed
  43. Analyst. 2015 Oct 21;140(20):6964-72 - PubMed
  44. J Am Chem Soc. 2010 Sep 29;132(38):13486-94 - PubMed

Publication Types

Grant support