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Tschirner A, Palus S, Hetzer R, et al. Six1 is down-regulated in end-stage human dilated cardiomyopathy independently of Ezh2. ESC Heart Fail. 2015;1(2):154-159doi: 10.1002/ehf2.12017.
Tschirner, A., Palus, S., Hetzer, R., Meyer, R., Anker, S. D., & Springer, J. (2014). Six1 is down-regulated in end-stage human dilated cardiomyopathy independently of Ezh2. ESC heart failure, 1(2), 154-159. https://doi.org/10.1002/ehf2.12017
Tschirner, Anika, et al. "Six1 is down-regulated in end-stage human dilated cardiomyopathy independently of Ezh2." ESC heart failure vol. 1,2 (2014): 154-159. doi: https://doi.org/10.1002/ehf2.12017
Tschirner A, Palus S, Hetzer R, Meyer R, Anker SD, Springer J. Six1 is down-regulated in end-stage human dilated cardiomyopathy independently of Ezh2. ESC Heart Fail. 2014 Dec;1(2):154-159. doi: 10.1002/ehf2.12017. Epub 2015 Jan 22. PMID: 27668088; PMCID: PMC5024036.
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ESC Heart Fail. 2014 Dec;1(2):154-159. doi: 10.1002/ehf2.12017. Epub 2015 Jan 22.

Six1 is down-regulated in end-stage human dilated cardiomyopathy independently of Ezh2.

ESC heart failure

Anika Tschirner, Sandra Palus, Roland Hetzer, Rudolf Meyer, Stefan D Anker, Jochen Springer

Affiliations

  1. Applied Cachexia Research, Department of CardiologyCharité Medical SchoolBerlinGermany; Center for Cardiovascular ResearchCharité Medical SchoolBerlinGermany.
  2. Department of Innovative Clinical Trials University Medical Centre Göttingen Göttingen Germany.
  3. DHZB Berlin Germany.

PMID: 27668088 PMCID: PMC5024036 DOI: 10.1002/ehf2.12017

Abstract

BACKGROUND: Recently, it was shown that a knock-out (KO) of the polycomb histone methyltransferase Ezh2 leads to cardiac hypertrophy in mice, which was driven by the homeodomain transcription factor Six1. Here, we analyzed the expression of Six1 and its regulating factor Ezh2 in cardiac tissue of patients with end-stage dilative cardiomyopathy (DCM).

METHODS: Tissue samples of patients with end-stage DCM (

RESULTS: Contrary to the Ezh2-KO mouse model, we found a down-regulation of Six1 (26%) and an up-regulation of Ezh2 (76%) in DCM hearts, (both

CONCLUSION: Our data indicate that the Ezh2/Six1 axis might be involved in human DCM. However, Six1 expression may be regulated by factors other than Ezh2, and more research is needed to determine the precise role of Ezh2/Six1 in human DCM.

Keywords: Cardiomyopathy; DCM; Signalling

References

  1. Jpn Circ J. 1987 Jun;51(6):676-81 - PubMed
  2. Heart Fail Rev. 2005 Sep;10(3):249-57 - PubMed
  3. Int Rev Cell Mol Biol. 2010;284:113-79 - PubMed
  4. J Clin Invest. 2011 Apr;121(4):1585-95 - PubMed
  5. Int J Cardiol. 2010 Aug 20;143(2):192-9 - PubMed
  6. Int J Cardiol. 2006 Aug 10;111(2):247-55 - PubMed
  7. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1625-32 - PubMed
  8. Clin Transl Sci. 2009 Oct;2(5):325-32 - PubMed
  9. Cell. 1992 Jun 26;69(7):1227-36 - PubMed
  10. Mol Cell. 2008 Nov 21;32(4):503-18 - PubMed
  11. Circ J. 2006 Jun;70(6):710-8 - PubMed
  12. Nat Genet. 2012 Jan 22;44(3):343-7 - PubMed
  13. ESC Heart Fail. 2014 Dec;1(2):154-159 - PubMed
  14. Mol Cell Biol. 2004 Jul;24(14):6253-67 - PubMed

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