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Kim YJ, Kim HR, Jeon HJ, et al. Rhabdomyolysis in a patient taking nebivolol. Kidney Res Clin Pract. 2016;35(3):182-6doi: 10.1016/j.krcp.2015.09.003.
Kim, Y. J., Kim, H. R., Jeon, H. J., Ju, H. J., Chung, S., Choi, D. E., Lee, K. W., & Na, K. R. (2016). Rhabdomyolysis in a patient taking nebivolol. Kidney research and clinical practice, 35(3), 182-6. https://doi.org/10.1016/j.krcp.2015.09.003
Kim, Ye Jin, et al. "Rhabdomyolysis in a patient taking nebivolol." Kidney research and clinical practice vol. 35,3 (2016): 182-6. doi: https://doi.org/10.1016/j.krcp.2015.09.003
Kim YJ, Kim HR, Jeon HJ, Ju HJ, Chung S, Choi DE, Lee KW, Na KR. Rhabdomyolysis in a patient taking nebivolol. Kidney Res Clin Pract. 2016 Sep;35(3):182-6. doi: 10.1016/j.krcp.2015.09.003. Epub 2016 Jan 22. PMID: 27668163; PMCID: PMC5025462.
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Kidney Res Clin Pract. 2016 Sep;35(3):182-6. doi: 10.1016/j.krcp.2015.09.003. Epub 2016 Jan 22.

Rhabdomyolysis in a patient taking nebivolol.

Kidney research and clinical practice

Ye Jin Kim, Hae Ri Kim, Hong Jae Jeon, Hyun Jun Ju, Sarah Chung, Dae Eun Choi, Kang Wook Lee, Ki Ryang Na

Affiliations

  1. Renal Division, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea.

PMID: 27668163 PMCID: PMC5025462 DOI: 10.1016/j.krcp.2015.09.003

Abstract

β Blockers such as propranolol and labetalol are known to induce toxic myopathy because of their partial β2 adrenoceptor agonistic effect. Nebivolol has the highest β1 receptor affinity among β blockers, and it has never been reported to induce rhabdomyolysis until now. We report a patient who developed rhabdomyolysis after changing medication to nebivolol. A 75-year-old woman was admitted to our hospital because of generalized weakness originating 2 weeks before visiting. Approximately 1 month before her admission, her medication was changed from carvedilol 12.5 mg to nebivolol 5 mg. Over this time span, she had no other lifestyle changes causing rhabdomyolysis. Her blood chemistry and whole body bone scan indicated rhabdomyolysis. We considered newly prescribed nebivolol as a causal agent. She was prescribed carvedilol 12.5 mg, which she was previously taking, instead of nebivolol. She was treated by hydration and urine alkalization. She had fully recovered and was discharged.

Keywords: Myopathies; Nebivolol; Rhabdomyolysis; β-adrenergic blockers

References

  1. Ann Pharmacother. 2001 Sep;35(9):1096-107 - PubMed
  2. Am J Med. 2006 May;119(5):400-9 - PubMed
  3. Br Med J. 1978 Sep 16;2(6140):833 - PubMed
  4. Am J Cardiovasc Drugs. 2010;10(3):175-86 - PubMed
  5. J Am Coll Cardiol. 2009 Oct 13;54(16):1491-9 - PubMed
  6. JAMA. 2004 Sep 15;292(11):1307-16 - PubMed
  7. Am Heart J. 2001 Jun;141(6):899-907 - PubMed
  8. Cardiovasc Ther. 2008 Fall;26(3):189-202 - PubMed
  9. J Card Fail. 2011 Sep;17(9):703-9 - PubMed
  10. Br J Pharmacol. 2004 Jun;142(4):667-70 - PubMed
  11. Physiol Rev. 2008 Apr;88(2):729-67 - PubMed
  12. Nucl Med Rev Cent East Eur. 2005;8(2):153-4 - PubMed
  13. N Engl J Med. 2009 Jul 2;361(1):62-72 - PubMed
  14. Am J Cardiol. 2013 Mar 1;111(5):765-9 - PubMed
  15. Circulation. 2000 Jan 18;101(2):207-13 - PubMed
  16. Am J Physiol Cell Physiol. 2006 Dec;291(6):C1208-12 - PubMed
  17. Rinsho Shinkeigaku. 1990 Jan;30(1):103-6 - PubMed
  18. Pediatr Neurol. 1990 Jul-Aug;6(4):275-6 - PubMed
  19. Nat Biotechnol. 2008 Mar;26(3):343-51 - PubMed
  20. Eur Heart J. 2012 Jul;33(13):1635-701 - PubMed
  21. Am Heart J. 2010 Mar;159(3):428-33 - PubMed
  22. Radiographics. 1993 Jul;13(4):715-34 - PubMed
  23. Drug Saf. 2000 Jun;22(6):441-57 - PubMed
  24. J Am Coll Cardiol. 2007 Jul 31;50(5):409-18 - PubMed
  25. Cardiovasc Drugs Ther. 1998 Sep;12(4):339-44 - PubMed
  26. Br J Clin Pharmacol. 1990 Nov;30(5):665-72 - PubMed
  27. BMC Res Notes. 2013 Feb 06;6:52 - PubMed
  28. Crit Care Med. 2005 Jun;33(6):1311-6 - PubMed
  29. J Clin Pharmacol. 1996 Aug;36(8):760-3 - PubMed
  30. J Nucl Med Technol. 2003 Sep;31(3):149-53; quiz 154-6 - PubMed
  31. J Am Soc Nephrol. 2000 Aug;11(8):1553-61 - PubMed
  32. Am J Cardiol. 2005 Feb 15;95(4):462-8 - PubMed
  33. Am J Cardiovasc Drugs. 2008;8(1):35-44 - PubMed
  34. J Pediatr Gastroenterol Nutr. 1990 May;10(4):544-7 - PubMed
  35. Hum Toxicol. 1985 Jan;4(1):57-60 - PubMed
  36. Clin Infect Dis. 1996 Apr;22(4):642-9 - PubMed
  37. Clin Exp Rheumatol. 1994 May-Jun;12 (3):309-11 - PubMed
  38. J Cardiovasc Pharmacol. 1988 May;11(5):552-63 - PubMed

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