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Dechavanne C, Sadissou I, Bouraima A, et al. Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors. Sci Rep. 2016;6:33961doi: 10.1038/srep33961.
Dechavanne, C., Sadissou, I., Bouraima, A., Ahouangninou, C., Amoussa, R., Milet, J., Moutairou, K., Massougbodji, A., Theisen, M., Remarque, E. J., Courtin, D., Nuel, G., Migot-Nabias, F., & Garcia, A. (2016). Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors. Scientific reports, 633961. https://doi.org/10.1038/srep33961
Dechavanne, Célia, et al. "Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors." Scientific reports vol. 6 (2016): 33961. doi: https://doi.org/10.1038/srep33961
Dechavanne C, Sadissou I, Bouraima A, Ahouangninou C, Amoussa R, Milet J, Moutairou K, Massougbodji A, Theisen M, Remarque EJ, Courtin D, Nuel G, Migot-Nabias F, Garcia A. Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors. Sci Rep. 2016 Sep 27;6:33961. doi: 10.1038/srep33961. PMID: 27670685; PMCID: PMC5037375.
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Sci Rep. 2016 Sep 27;6:33961. doi: 10.1038/srep33961.

Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors.

Scientific reports

Célia Dechavanne, Ibrahim Sadissou, Aziz Bouraima, Claude Ahouangninou, Roukiyath Amoussa, Jacqueline Milet, Kabirou Moutairou, Achille Massougbodji, Michael Theisen, Edmond J Remarque, David Courtin, Gregory Nuel, Florence Migot-Nabias, André Garcia

Affiliations

  1. Institut de Recherche pour le Développement, UMR 216 Mère et enfant face aux infections tropicales, Paris, France.
  2. COMUE Sorbonne Paris Cité, Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
  3. Centre d'Etude et de Recherche sur le Paludisme Associé à la Grossesse et l'Enfance (CERPAGE); Faculté des Sciences de la Santé, Cotonou, Bénin.
  4. Laboratoire de Biologie et Physiologie Cellulaires, Faculté des Sciences et Techniques (FAST), Université d'Abomey-Calavi, Cotonou, Bénin.
  5. Department for Congenital disorders, Statens Serum Institut, Copenhagen, Denmark.
  6. Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  7. Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands.
  8. Laboratoire de Mathématiques Appliquées (MAP5) UMR CNRS 8145 Université Paris Descartes, Paris, France.

PMID: 27670685 PMCID: PMC5037375 DOI: 10.1038/srep33961

Abstract

To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.

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