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Li J, Gao H, Tian Z, et al. Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary. J Anim Sci Biotechnol. 2016;7:57doi: 10.1186/s40104-016-0116-6.
Li, J., Gao, H., Tian, Z., Wu, Y., Wang, Y., Fang, Y., Lin, L., Han, Y., Wu, S., Haq, I., & Zeng, S. (2016). Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary. Journal of animal science and biotechnology, 757. https://doi.org/10.1186/s40104-016-0116-6
Li, Jieyun, et al. "Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary." Journal of animal science and biotechnology vol. 7 (2016): 57. doi: https://doi.org/10.1186/s40104-016-0116-6
Li J, Gao H, Tian Z, Wu Y, Wang Y, Fang Y, Lin L, Han Y, Wu S, Haq I, Zeng S. Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary. J Anim Sci Biotechnol. 2016 Sep 29;7:57. doi: 10.1186/s40104-016-0116-6. eCollection 2016. PMID: 27708774; PMCID: PMC5043540.
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J Anim Sci Biotechnol. 2016 Sep 29;7:57. doi: 10.1186/s40104-016-0116-6. eCollection 2016.

Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary.

Journal of animal science and biotechnology

Jieyun Li, Hui Gao, Zhen Tian, Yi Wu, Yingzheng Wang, Yuan Fang, Lu Lin, Ying Han, Shuaishuai Wu, IhteshamUl Haq, Shenming Zeng

Affiliations

  1. Laboratory of Animal Embryonic Biotechnology; National Engineering Laboratory for Animal Breeding; Key Laboratory of Animal Genetics, Breeding, and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, 100193 China.
  2. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101 China.

PMID: 27708774 PMCID: PMC5043540 DOI: 10.1186/s40104-016-0116-6

Abstract

BACKGROUND: Heat stress is known to alter follicular dynamics and granulosa cell function and may contribute to the diminished reproductive efficiency commonly observed in mammals during the summer. Although several investigators have studied heat-induced ovarian injury, few reports have focused on the effects of chronic heat stress on ovarian function and the molecular mechanisms through which it induces ovarian injury.

METHODS: In Exp. 1, 48 female mice were assigned to a control or heat-stressed treatment. After exposure to a constant temperature of 25 °C for 7, 14, 21 or 28 d (

RESULTS: In Exp. 1, body weight and food intake of heat-stressed mice decreased (

CONCLUSION: Heat-stress in mice decrease estradiol in serum and aromatase in antral follicles but increased number of atretic follicles and granulosa cell undergoing apoptosis which may explain the decreased fertility commonly observed in heat-stressed animals.

Keywords: Apoptosis; Atresia; Follicle; Granulosa cells; Heat stress; Mice

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