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Hiranuma K, Yamada A, Kurosawa T, et al. Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3. FEBS Open Bio. 2016;6(9):914-8doi: 10.1002/2211-5463.12085.
Hiranuma, K., Yamada, A., Kurosawa, T., Aizawa, R., Suzuki, D., Saito, Y., Nagahama, R., Ikehata, M., Tsukasaki, M., Morimura, N., Chikazu, D., Maki, K., Shirota, T., Takami, M., Yamamoto, M., Iijima, T., & Kamijo, R. (2016). Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3. FEBS open bio, 6(9), 914-8. https://doi.org/10.1002/2211-5463.12085
Hiranuma, Katsuhiro, et al. "Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3." FEBS open bio vol. 6,9 (2016): 914-8. doi: https://doi.org/10.1002/2211-5463.12085
Hiranuma K, Yamada A, Kurosawa T, Aizawa R, Suzuki D, Saito Y, Nagahama R, Ikehata M, Tsukasaki M, Morimura N, Chikazu D, Maki K, Shirota T, Takami M, Yamamoto M, Iijima T, Kamijo R. Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3. FEBS Open Bio. 2016 Jul 13;6(9):914-8. doi: 10.1002/2211-5463.12085. eCollection 2016 Sep. PMID: 27642554; PMCID: PMC5011489.
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FEBS Open Bio. 2016 Jul 13;6(9):914-8. doi: 10.1002/2211-5463.12085. eCollection 2016 Sep.

Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3.

FEBS open bio

Katsuhiro Hiranuma, Atsushi Yamada, Tamaki Kurosawa, Ryo Aizawa, Dai Suzuki, Yoshiro Saito, Ryo Nagahama, Mikiko Ikehata, Masayuki Tsukasaki, Naoko Morimura, Daichi Chikazu, Koutaro Maki, Tatsuo Shirota, Masamichi Takami, Matsuo Yamamoto, Takehiko Iijima, Ryutaro Kamijo

Affiliations

  1. Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Perioperative Medicine Division of Anesthesiology School of Dentistry Showa University Tokyo Japan.
  2. Department of Biochemistry School of Dentistry Showa University Tokyo Japan.
  3. Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Periodontology School of Dentistry Showa University Tokyo Japan.
  4. Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Oral and Maxillofacial Surgery School of Dentistry Showa University Tokyo Japan.
  5. Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Orthodontics School of Dentistry Showa University Tokyo Japan.
  6. Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Oral and Maxillofacial Surgery Tokyo Medical University Japan.
  7. Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Present address: Department of Immunology Graduate School of Medicine and Faculty of Medicine The University of Tokyo Hongo 7-3-1, Bunkyo-ku Tokyo 113-0033 Japan.
  8. Brain Science Laboratory The Research Organization of Science and Technology Ritsumeikan University Kusatsu Shiga Japan.
  9. Department of Oral and Maxillofacial Surgery Tokyo Medical University Japan.
  10. Department of Orthodontics School of Dentistry Showa University Tokyo Japan.
  11. Department of Oral and Maxillofacial Surgery School of Dentistry Showa University Tokyo Japan.
  12. Department of Pharmacology School of Dentistry Showa University Tokyo Japan.
  13. Department of Periodontology School of Dentistry Showa University Tokyo Japan.
  14. Department of Perioperative Medicine Division of Anesthesiology School of Dentistry Showa University Tokyo Japan.

PMID: 27642554 PMCID: PMC5011489 DOI: 10.1002/2211-5463.12085

Abstract

The extracellular matrix protein nephronectin (Npnt), also called POEM, is considered to play critical roles as an adhesion molecule in development and functions of various tissues, such as the kidneys, liver, and bone. In the present study, we examined the molecular mechanism of Npnt gene expression and found that vitamin D3 (1α,25-dihydroxyvitamin D3,VD 3) strongly enhanced Npnt mRNA expression in MC3T3-E1 cells from a mouse osteoblastic cell line. The VD 3-induced increase in Npnt expression is both time- and dose-dependent and is mediated by the vitamin D receptor (VDR).

Keywords: 1α,25‐dihydroxyvitamin D3; nephronectin; vitamin D receptor

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