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J Phys Chem B. 2016 Oct 27;120(42):10923-10931. doi: 10.1021/acs.jpcb.6b06587. Epub 2016 Oct 17.

EPR Study of UV-Irradiated Thymidine Microcrystals Supports Radical Intermediates in Spore Photoproduct Formation.

The journal of physical chemistry. B

Ellen C Hayes, Yajun Jian, Lei Li, Stefan Stoll

Affiliations

  1. Department of Chemistry, Box 351700, University of Washington , Seattle, Washington 98195, United States.
  2. Department of Chemistry and Chemical Biology, 402 N. Blackford Street, LD 326, Indiana University-Purdue University Indianapolis , Indianapolis, Indiana 46202, United States.

PMID: 27648491 DOI: 10.1021/acs.jpcb.6b06587

Abstract

Spore photoproduct is a thymidine dimer formed when bacterial endospore DNA is exposed to ultraviolet (UV) radiation. The mechanism of formation of this thymidine dimer has been proposed to proceed through a radical-pair intermediate. The intermediate forms when a methyl-group hydrogen atom of one thymidine nucleobase is transferred to the C6 position of an adjacent thymidine nucleobase, forming two species, the TCH

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