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Jang JS, Shin HC, Bae JS, et al. Diagnostic Performance of Intravascular Ultrasound-Derived Minimal Lumen Area to Predict Functionally Significant Non-Left Main Coronary Artery Disease: a Meta-Analysis. Korean Circ J. 2016;46(5):622-631doi: 10.4070/kcj.2016.46.5.622.
Jang, J. S., Shin, H. C., Bae, J. S., Jin, H. Y., Seo, J. S., Yang, T. H., Kim, D. K., Cho, K. I., Kim, B. H., Park, Y. H., Je, H. G., & Kim, D. S. (2016). Diagnostic Performance of Intravascular Ultrasound-Derived Minimal Lumen Area to Predict Functionally Significant Non-Left Main Coronary Artery Disease: a Meta-Analysis. Korean circulation journal, 46(5), 622-631. https://doi.org/10.4070/kcj.2016.46.5.622
Jang, Jae-Sik, et al. "Diagnostic Performance of Intravascular Ultrasound-Derived Minimal Lumen Area to Predict Functionally Significant Non-Left Main Coronary Artery Disease: a Meta-Analysis." Korean circulation journal vol. 46,5 (2016): 622-631. doi: https://doi.org/10.4070/kcj.2016.46.5.622
Jang JS, Shin HC, Bae JS, Jin HY, Seo JS, Yang TH, Kim DK, Cho KI, Kim BH, Park YH, Je HG, Kim DS. Diagnostic Performance of Intravascular Ultrasound-Derived Minimal Lumen Area to Predict Functionally Significant Non-Left Main Coronary Artery Disease: a Meta-Analysis. Korean Circ J. 2016 Sep;46(5):622-631. doi: 10.4070/kcj.2016.46.5.622. Epub 2016 Sep 28. PMID: 27721852; PMCID: PMC5054173.
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Korean Circ J. 2016 Sep;46(5):622-631. doi: 10.4070/kcj.2016.46.5.622. Epub 2016 Sep 28.

Diagnostic Performance of Intravascular Ultrasound-Derived Minimal Lumen Area to Predict Functionally Significant Non-Left Main Coronary Artery Disease: a Meta-Analysis.

Korean circulation journal

Jae-Sik Jang, Ho-Cheol Shin, Jong Seok Bae, Han-Young Jin, Jeong-Sook Seo, Tae-Hyun Yang, Dae-Kyeong Kim, Kyoung-Im Cho, Bo-Hyun Kim, Yong Hyun Park, Hyung-Gon Je, Dong-Soo Kim

Affiliations

  1. Division of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, Korea.
  2. Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
  3. Division of Cardiology, Kosin University Medical Center, Busan, Korea.
  4. Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
  5. Division of Cardiology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  6. Department of Cardiovascular Surgery, Busan National University Yangsan Hospital, Yangsan, Korea.

PMID: 27721852 PMCID: PMC5054173 DOI: 10.4070/kcj.2016.46.5.622

Abstract

BACKGROUND AND OBJECTIVES: Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention frequently results in unnecessary stenting due to the low positive predictive value of IVUS-derived minimal lumen area (MLA) for identification of functionally significant coronary stenosis. We appraised the diagnostic accuracy of IVUS-derived MLA compared with the fractional flow reserve (FFR) to assess intermediate coronary stenosis.

SUBJECTS AND METHODS: We searched MEDLINE and Cochrane databases for studies using IVUS and FFR methods to establish the best MLA cut-off values to predict significant non-left main coronary artery stenosis. Summary estimates were obtained using a random-effects model.

RESULTS: The 17 studies used in our analysis enrolled 3920 patients with 4267 lesions. The weighted overall mean MLA cut-off value was 2.58 mm

CONCLUSION: IVUS-derived MLA has limited diagnostic accuracy and needs careful interpretation to correlate with functionally significant non-left main coronary artery stenosis.

Keywords: Fractional flow reserve; Intravascular ultrasonography; Percutaneous coronary intervention

Conflict of interest statement

The authors have no financial conflicts of interest.

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