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Chen X, Yang L, Udar N, et al. CAND3: A ubiquitously expressed gene immediately adjacent and in opposite transcriptional orientation to the ATM gene at 1lq23.1. Mamm Genome. 1997;8(2):129-33doi: 10.1007/s003359900371.
Chen, X., Yang, L., Udar, N., Liang, T., Uhrhammer, N., Xu, S., Bay, J. O., Wang, Z., Dandakar, S., Chiplunkar, S., Klisak, I., Telatar, M., Yang, H., Concannon, P., & Gatti, R. A. (1997). CAND3: A ubiquitously expressed gene immediately adjacent and in opposite transcriptional orientation to the ATM gene at 1lq23.1. Mammalian genome : official journal of the International Mammalian Genome Society, 8(2), 129-33. https://doi.org/10.1007/s003359900371
Chen, X, et al. "CAND3: A ubiquitously expressed gene immediately adjacent and in opposite transcriptional orientation to the ATM gene at 1lq23.1." Mammalian genome : official journal of the International Mammalian Genome Society vol. 8,2 (1997): 129-33. doi: https://doi.org/10.1007/s003359900371
Chen X, Yang L, Udar N, Liang T, Uhrhammer N, Xu S, Bay JO, Wang Z, Dandakar S, Chiplunkar S, Klisak I, Telatar M, Yang H, Concannon P, Gatti RA. CAND3: A ubiquitously expressed gene immediately adjacent and in opposite transcriptional orientation to the ATM gene at 1lq23.1. Mamm Genome. 1997 Feb;8(2):129-33. doi: 10.1007/s003359900371. PMID: 27518307.
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Mamm Genome. 1997 Feb;8(2):129-33. doi: 10.1007/s003359900371.

CAND3: A ubiquitously expressed gene immediately adjacent and in opposite transcriptional orientation to the ATM gene at 1lq23.1.

Mammalian genome : official journal of the International Mammalian Genome Society

X Chen, L Yang, N Udar, T Liang, N Uhrhammer, S Xu, J O Bay, Z Wang, S Dandakar, S Chiplunkar, I Klisak, M Telatar, H Yang, P Concannon, R A Gatti

Affiliations

  1. Department of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
  2. Virginia Mason Research Center and the Department of Immunology, University of Washington School of Medicine, 98101, Seattle, Washington, USA.

PMID: 27518307 DOI: 10.1007/s003359900371

Abstract

Using a magnetic beads-mediated cDNA selection procedure and a fetal brain expression library, we identified a transcriptional unit within a cosmid positive for the marker D11S384. Pursuit of its full-length cDNA led to the cloning of the third candidate gene (CAND3) we studied in our quest for the ataxiatelangiectasia (A-T) gene, ATM. CAND3 spans ~140 kb of genomic DNA and is located immediately centrimeric to ATM, with 544 bp of DNA separating the two genes. CAND3 encodes two ubiquitously expressed transcripts of ~5.8 kb and ~4.6 kb that are divergently transcribed from a promoter region common to ATM. Nucleotide sequence was determined for one of its alternately spliced transcripts. The predicted protein has 1175 amino acids and is novel in sequence, with only weak homologies to transcriptional factors, nucleoporin protein, and protein kinases, including members of the phosphatidylinositol 3-kinase (PI-3 kinase) family. Although neither homology to ATM nor any mutation of CAND3 in A-T patients has been found, the head-to-head arrangement of CAND3 and ATM, with expression of both housekeeping genes from a common stretch of 544 bp intergenic DNA, suggests a bi-directional promoter possibly for co-regulation of biologically related functions. YACs, BACs, cosmids, and STSs are defined to aid in the further study of this gene.

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