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Hubbard CS, Becerra L, Smith JH, et al. Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal. Front Hum Neurosci. 2016;10:497doi: 10.3389/fnhum.2016.00497.
Hubbard, C. S., Becerra, L., Smith, J. H., DeLange, J. M., Smith, R. M., Black, D. F., Welker, K. M., Burstein, R., Cutrer, F. M., & Borsook, D. (2016). Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal. Frontiers in human neuroscience, 10497. https://doi.org/10.3389/fnhum.2016.00497
Hubbard, Catherine S, et al. "Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal." Frontiers in human neuroscience vol. 10 (2016): 497. doi: https://doi.org/10.3389/fnhum.2016.00497
Hubbard CS, Becerra L, Smith JH, DeLange JM, Smith RM, Black DF, Welker KM, Burstein R, Cutrer FM, Borsook D. Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal. Front Hum Neurosci. 2016 Oct 06;10:497. doi: 10.3389/fnhum.2016.00497. eCollection 2016. PMID: 27766076; PMCID: PMC5052273.
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Front Hum Neurosci. 2016 Oct 06;10:497. doi: 10.3389/fnhum.2016.00497. eCollection 2016.

Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal.

Frontiers in human neuroscience

Catherine S Hubbard, Lino Becerra, Jonathan H Smith, Justin M DeLange, Ryan M Smith, David F Black, Kirk M Welker, Rami Burstein, Fred M Cutrer, David Borsook

Affiliations

  1. Center for Pain and the Brain, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's HospitalBoston, MA, USA; Department of Anaesthesia, Harvard Medical SchoolBoston, MA, USA.
  2. Department of Neurology, Mayo Clinic Rochester, MN, USA.
  3. Department of Anaesthesia, Harvard Medical SchoolBoston, MA, USA; Department of Anaesthesia, Beth Israel Deaconess Medical CenterBoston, MA, USA.

PMID: 27766076 PMCID: PMC5052273 DOI: 10.3389/fnhum.2016.00497

Abstract

The aim of this study was to identify structural and functional brain changes that accompanied the transition from chronic (CM; ≥15 headache days/month) to episodic (EM; <15 headache days/month) migraine following prophylactic treatment with onabotulinumtoxinA (BoNT-A). Specifically, we examined whether CM patients responsive to prophylaxis (responders;

Keywords: BOTOX®; fMRI; gray matter; headache; migraine transformation; network connectivity; pain; preventative therapy

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