Display options
Cite
Jiang N, Cui Y, Liu J, et al. Multidimensional Roles of Collagen Triple Helix Repeat Containing 1 (CTHRC1) in Malignant Cancers. J Cancer. 2016;7(15):2213-2220doi: 10.7150/jca.16539.
Jiang, N., Cui, Y., Liu, J., Zhu, X., Wu, H., Yang, Z., & Ke, Z. (2016). Multidimensional Roles of Collagen Triple Helix Repeat Containing 1 (CTHRC1) in Malignant Cancers. Journal of Cancer, 7(15), 2213-2220. https://doi.org/10.7150/jca.16539
Jiang, Neng, et al. "Multidimensional Roles of Collagen Triple Helix Repeat Containing 1 (CTHRC1) in Malignant Cancers." Journal of Cancer vol. 7,15 (2016): 2213-2220. doi: https://doi.org/10.7150/jca.16539
Jiang N, Cui Y, Liu J, Zhu X, Wu H, Yang Z, Ke Z. Multidimensional Roles of Collagen Triple Helix Repeat Containing 1 (CTHRC1) in Malignant Cancers. J Cancer. 2016 Oct 25;7(15):2213-2220. doi: 10.7150/jca.16539. eCollection 2016. PMID: 27994657; PMCID: PMC5166530.
Copy Download .nbib Format: NLM
Share it on

J Cancer. 2016 Oct 25;7(15):2213-2220. doi: 10.7150/jca.16539. eCollection 2016.

Multidimensional Roles of Collagen Triple Helix Repeat Containing 1 (CTHRC1) in Malignant Cancers.

Journal of Cancer

Neng Jiang, YongMei Cui, JunXiu Liu, XiaoLin Zhu, Hui Wu, Zheng Yang, ZunFu Ke

Affiliations

  1. Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Province Guangdong, P.R. China.
  2. Department of Gynecology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Province Guangdong, P.R. China.
  3. Department of Otolaryngology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Province Guangdong, P.R. China.
  4. Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Province Guangdong, P.R. China.

PMID: 27994657 PMCID: PMC5166530 DOI: 10.7150/jca.16539

Abstract

Tumor is one of the principal diseases that seriously threaten human health. Insight into sensitive cancer markers may open a new avenue for the early diagnosis and treatment of this disease. CTHRC1 has been identified as a cancer-related gene. It is a secretory glycoprotein that possesses multidimensional roles associated with wound repair, bone remodeling, hepatocytes fibrosis, adipose tissue formation, and so on. Our previous studies and numerous reports from other researchers have revealed that the ascended expression of CTHRC1 tends to go hand in hand with tumorigenesis, proliferation, invasion and metastasis in various human malignancies through a series of molecular mechanisms and signaling pathways. However, the detailed pathogenic mechanisms of CTHRC1 overexpression in human malignant cancers are not yet clear. Here, we shall focus our description on the functions, expression profile in several representative malignant tumors and a number of molecular mechanisms and signaling pathways involved with CTHRC1. This introductory discussion of CTHRC1 will serve as a reference for further research in understanding this intriguing cancer-related protein.

Keywords: CTHRC1; cancers; markers; signaling pathways; treatment

Conflict of interest statement

The authors have declared that no competing interest exists.

References

  1. Biochem Biophys Res Commun. 2010 Aug 27;399(3):434-9 - PubMed
  2. J Autoimmun. 2015 Sep;63:76-87 - PubMed
  3. Development. 2009 Oct;136(19):3205-14 - PubMed
  4. Int J Med Sci. 2015 Nov 01;12(12):937-45 - PubMed
  5. J Clin Oncol. 2009 Nov 1;27(31):5287-97 - PubMed
  6. Circ Res. 2005 Feb 4;96(2):261-8 - PubMed
  7. PLoS One. 2013 Jul 29;8(7):e70324 - PubMed
  8. Mol Carcinog. 2015 Oct;54(10):1086-95 - PubMed
  9. J Biol Chem. 2006 Aug 11;281(32):22429-33 - PubMed
  10. Mol Cell. 2003 Nov;12(5):1275-85 - PubMed
  11. Pathol Oncol Res. 2013 Oct;19(4):731-7 - PubMed
  12. Blood. 2006 Nov 1;108(9):3035-44 - PubMed
  13. Int J Oncol. 2014 Aug;45(2):541-8 - PubMed
  14. Br J Dermatol. 2011 May;164(5):1030-6 - PubMed
  15. Sci Rep. 2016 Feb 24;6:21903 - PubMed
  16. Am J Cancer Res. 2015 Mar 15;5(4):1447-59 - PubMed
  17. Mol Carcinog. 2015 Dec;54(12):1554-66 - PubMed
  18. Oncotarget. 2014 Oct 15;5(19):9410-24 - PubMed
  19. J Biol Chem. 2012 Jul 13;287(29):24103-12 - PubMed
  20. Dev Cell. 2008 Jul;15(1):23-36 - PubMed
  21. Br J Dermatol. 2011 Jan;164(1):135-40 - PubMed
  22. Int J Oncol. 2007 Apr;30(4):985-92 - PubMed
  23. Mol Biol Rep. 2012 Mar;39(3):3029-35 - PubMed
  24. J Med Genet. 2001 May;38(5):285-303 - PubMed
  25. Cancer Sci. 2011 Apr;102(4):815-27 - PubMed
  26. J Gastrointest Cancer. 2012 Sep;43(3):462-6 - PubMed
  27. Methods Mol Biol. 2016;1395:137-62 - PubMed
  28. J Clin Invest. 2011 May;121(5):1935-45 - PubMed
  29. Science. 1995 Apr 14;268(5208):233-9 - PubMed
  30. Oncotarget. 2014 Jan 30;5(2):519-29 - PubMed
  31. Oncogene. 2001 May 28;20(24):3139-55 - PubMed
  32. Oncotarget. 2015 Nov 3;6(34):35813-29 - PubMed
  33. Mol Med Rep. 2016 Mar;13(3):2639-44 - PubMed
  34. Neoplasia. 2014 Mar;16(3):265-78, 278.e1-13 - PubMed
  35. Carcinogenesis. 2013 Mar;34(3):694-702 - PubMed
  36. Clin Cancer Res. 2009 Jan 1;15(1):60-9 - PubMed
  37. Carcinogenesis. 1998 Mar;19(3):445-55 - PubMed
  38. J Cell Sci. 2014 Mar 1;127(Pt 5):967-76 - PubMed
  39. Tumour Biol. 2015 May;36(5):3221-9 - PubMed
  40. PLoS One. 2012;7(10):e47142 - PubMed
  41. Clin Cancer Res. 2006 Jun 15;12(12):3716-22 - PubMed
  42. Mol Cell. 2004 Oct 22;16(2):257-67 - PubMed
  43. J Clin Invest. 2013 Sep;123(9):3914-24 - PubMed
  44. Circ Res. 2007 Mar 30;100(6):826-33 - PubMed
  45. Trends Cardiovasc Med. 2007 Aug;17(6):202-5 - PubMed
  46. Gene Expr Patterns. 2006 Oct;6(8):935-40 - PubMed
  47. J Clin Pathol. 2011 Nov;64(11):977-82 - PubMed
  48. Cancer Sci. 2012 Jul;103(7):1327-33 - PubMed
  49. J Biol Chem. 2010 Oct 8;285(41):31164-73 - PubMed
  50. Int J Mol Med. 2012 Jun;29(6):1158-64 - PubMed
  51. Int J Cancer. 2012 May 1;130(9):2067-76 - PubMed
  52. N Engl J Med. 1986 Dec 25;315(26):1650-9 - PubMed
  53. Science. 1999 Aug 13;285(5430):1028-32 - PubMed
  54. Int J Cancer. 1997 Sep 17;72(6):1013-20 - PubMed
  55. PLoS One. 2008 Sep 09;3(9):e3174 - PubMed
  56. Obesity (Silver Spring). 2015 Aug;23(8):1633-42 - PubMed
  57. Am J Pathol. 1994 Jul;145(1):97-104 - PubMed
  58. Food Chem Toxicol. 2016 Dec;98 (Pt A):58-65 - PubMed
  59. Tumour Biol. 2014 Nov;35(11):11677-83 - PubMed
  60. Trends Mol Med. 2008 May;14(5):199-209 - PubMed
  61. Cancer Cell Int. 2015 Sep 17;15:85 - PubMed
  62. J Biol Chem. 2013 Jul 12;288(28):20217-27 - PubMed
  63. Nature. 2004 Nov 18;432(7015):324-31 - PubMed
  64. FEBS Lett. 2010 Nov 19;584(22):4575-80 - PubMed
  65. Biochem J. 2010 Mar 15;427(1):1-17 - PubMed
  66. Nat Rev Cancer. 2003 Jun;3(6):411-21 - PubMed
  67. J Mol Cell Biol. 2015 Dec;7(6):543-56 - PubMed
  68. J Cell Biol. 1999 Jun 28;145(7):1461-9 - PubMed
  69. FEBS J. 2011 Jan;278(1):16-27 - PubMed
  70. Int J Clin Exp Pathol. 2015 Oct 01;8(10 ):12793-801 - PubMed
  71. Med Oncol. 2013 Mar;30(1):473 - PubMed
  72. Dev Cell. 2008 Jul;15(1):7-8 - PubMed
  73. Oncotarget. 2016 Mar 22;7(12):15065-92 - PubMed
  74. Oncogene. 2014 May 8;33(19):2464-77 - PubMed

Publication Types