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Hayashi S, Nishida T, Shimakoshi H, et al. Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc. 2016;8(20):777-784doi: 10.4253/wjge.v8.i20.777.
Hayashi, S., Nishida, T., Shimakoshi, H., Shimoda, A., Amano, T., Sugimoto, A., Takahashi, K., Mukai, K., Matsubara, T., Yamamoto, M., Nakajima, S., Fukui, K., & Inada, M. (2016). Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis. World journal of gastrointestinal endoscopy, 8(20), 777-784. https://doi.org/10.4253/wjge.v8.i20.777
Hayashi, Shiro, et al. "Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis." World journal of gastrointestinal endoscopy vol. 8,20 (2016): 777-784. doi: https://doi.org/10.4253/wjge.v8.i20.777
Hayashi S, Nishida T, Shimakoshi H, Shimoda A, Amano T, Sugimoto A, Takahashi K, Mukai K, Matsubara T, Yamamoto M, Nakajima S, Fukui K, Inada M. Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc. 2016 Dec 16;8(20):777-784. doi: 10.4253/wjge.v8.i20.777. PMID: 28042392; PMCID: PMC5159676.
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World J Gastrointest Endosc. 2016 Dec 16;8(20):777-784. doi: 10.4253/wjge.v8.i20.777.

Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis.

World journal of gastrointestinal endoscopy

Shiro Hayashi, Tsutomu Nishida, Hiromi Shimakoshi, Akiyoshi Shimoda, Takahiro Amano, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Tokuhiro Matsubara, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui, Masami Inada

Affiliations

  1. Shiro Hayashi, Tsutomu Nishida, Hiromi Shimakoshi, Akiyoshi Shimoda, Takahiro Amano, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Tokuhiro Matsubara, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui, Masami Inada, Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, Osaka 560-8565, Japan.

PMID: 28042392 PMCID: PMC5159676 DOI: 10.4253/wjge.v8.i20.777

Abstract

AIM: To estimate the efficacy of 2 h post-endoscopic retrograde cholangiopancreatography (ERCP) serum amylase levels and other factors for predicting post-ERCP pancreatitis.

METHODS: This was a retrospective, single-center cohort study of consecutive patients who underwent ERCP from January 2010 to December 2013. Serum amylase levels were measured 2 h post-procedure, and patient- and procedure-related pancreatitis (PEP) risk factors were analyzed using a logistic model.

RESULTS: A total of 1520 cases (average age 72 ± 12 years, 60% male) were initially enrolled in this study, and 1403 cases (725 patients) were ultimately analyzed after the exclusion of 117 cases. Fifty-five of these cases developed PEP. We established a 2 h serum amylase cutoff level of two times the upper limit of normal for predicting PEP. Multivariate analysis revealed that a cannulation time of more than 13 min [odds ratio (OR) 2.28, 95%CI: 1.132-4.651,

CONCLUSION: These findings indicate that the combination of 2 h post-ERCP serum amylase levels and cannulation times represents a valuable marker for identifying patients at high risk for PEP.

Keywords: Cannulation time; Post-endoscopic retrograde cholangiopancreatography pancreatitis; Predictor; Serum amylase levels

Conflict of interest statement

Conflict-of-interest statement: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.

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