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Tise CG, Anforth LE, Zhou AE, et al. Sex-specific effects of serum sulfate level and . Mol Genet Metab Rep. 2017;10:84-91doi: 10.1016/j.ymgmr.2017.01.005.
Tise, C. G., Anforth, L. E., Zhou, A. E., Perry, J. A., McArdle, P. F., Streeten, E. A., Shuldiner, A. R., & Yerges-Armstrong, L. M. (2017). Sex-specific effects of serum sulfate level and . Molecular genetics and metabolism reports, 1084-91. https://doi.org/10.1016/j.ymgmr.2017.01.005
Tise, Christina G, et al. "Sex-specific effects of serum sulfate level and ." Molecular genetics and metabolism reports vol. 10 (2017): 84-91. doi: https://doi.org/10.1016/j.ymgmr.2017.01.005
Tise CG, Anforth LE, Zhou AE, Perry JA, McArdle PF, Streeten EA, Shuldiner AR, Yerges-Armstrong LM. Sex-specific effects of serum sulfate level and . Mol Genet Metab Rep. 2017 Jan 27;10:84-91. doi: 10.1016/j.ymgmr.2017.01.005. eCollection 2017 Mar. PMID: 28154797; PMCID: PMC5278115.
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Mol Genet Metab Rep. 2017 Jan 27;10:84-91. doi: 10.1016/j.ymgmr.2017.01.005. eCollection 2017 Mar.

Sex-specific effects of serum sulfate level and .

Molecular genetics and metabolism reports

Christina G Tise, Leslie E Anforth, Albert E Zhou, James A Perry, Patrick F McArdle, Elizabeth A Streeten, Alan R Shuldiner, Laura M Yerges-Armstrong

Affiliations

  1. Program for Personalized and Genomic Medicine and Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, United States.

PMID: 28154797 PMCID: PMC5278115 DOI: 10.1016/j.ymgmr.2017.01.005

Abstract

CONTEXT: Sulfate is critical in the biotransformation of multiple compounds via sulfation. These compounds include neurotransmitters, proteoglycans, xenobiotics, and hormones such as dehydroepiandrosterone (DHEA). Sulfation reactions are thought to be rate-limited by endogenous sulfate concentrations. The gene,

OBJECTIVE: To examine the effect of serum sulfate concentration and sulfate-lowering genotype on DHEA homeostasis.

DESIGN: Retrospective cohort study.

SETTING: Academic research.

PATIENTS: Participants of the Amish Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study and the Amish Hereditary and Phenotype Intervention (HAPI) Study.

MAIN OUTCOME MEASURES: DHEA, DHEA-S, and DHEA-S/DHEA ratio.

RESULTS: Increased serum sulfate was associated with decreased DHEA-S (

CONCLUSIONS: Our results demonstrate an inverse relationship between serum sulfate, and DHEA-S and DHEA-S/DHEA ratio in men, while also suggesting that the sulfate-lowering variants,

Keywords: DHEA; DHEA-S; SLC13A1; Serum sulfate; Sulfation

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