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Virus Evol. 2016 Oct 26;2(2):vew033. doi: 10.1093/ve/vew033. eCollection 2016 Jul.

Transmission bottlenecks and RNAi collectively influence tick-borne flavivirus evolution.

Virus evolution

Nathan D Grubaugh, Claudia Rückert, Philip M Armstrong, Angela Bransfield, John F Anderson, Gregory D Ebel, Doug E Brackney

Affiliations

  1. Department of Microbiology Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO, USA.
  2. The Connecticut Agricultural Experiment Station, Center for Vector Biology and Zoonotic Diseases, New Haven, CT, USA.

PMID: 28058113 PMCID: PMC5210029 DOI: 10.1093/ve/vew033

Abstract

Arthropod-borne RNA viruses exist within hosts as heterogeneous populations of viral variants and, as a result, possess great genetic plasticity. Understanding the micro-evolutionary forces shaping these viruses can provide insights into how they emerge, adapt, and persist in new and changing ecological niches. While considerable attention has been directed toward studying the population dynamics of mosquito-borne viruses, little is known about tick-borne virus populations. Therefore, using a mouse and

Keywords: Ixodes; Powassan virus; RNAi; evolution; flavivirus; tick.

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