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Gómez-Ríos GA, Liu C, Tascon M, et al. Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry. Anal Chem. 2017;89(7):3805-3809doi: 10.1021/acs.analchem.6b04737.
Gómez-Ríos, G. A., Liu, C., Tascon, M., Reyes-Garcés, N., Arnold, D. W., Covey, T. R., & Pawliszyn, J. (2017). Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry. Analytical chemistry, 89(7), 3805-3809. https://doi.org/10.1021/acs.analchem.6b04737
Gómez-Ríos, Germán Augusto, et al. "Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry." Analytical chemistry vol. 89,7 (2017): 3805-3809. doi: https://doi.org/10.1021/acs.analchem.6b04737
Gómez-Ríos GA, Liu C, Tascon M, Reyes-Garcés N, Arnold DW, Covey TR, Pawliszyn J. Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry. Anal Chem. 2017 Apr 04;89(7):3805-3809. doi: 10.1021/acs.analchem.6b04737. Epub 2017 Feb 13. PMID: 28192911.
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Anal Chem. 2017 Apr 04;89(7):3805-3809. doi: 10.1021/acs.analchem.6b04737. Epub 2017 Feb 13.

Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry.

Analytical chemistry

Germán Augusto Gómez-Ríos, Chang Liu, Marcos Tascon, Nathaly Reyes-Garcés, Don W Arnold, Thomas R Covey, Janusz Pawliszyn

Affiliations

  1. Department of Chemistry, University of Waterloo , Waterloo, Ontario N2L 3G1, Canada.
  2. SCIEX , 71 Four Valley Drive, Concord, Ontario L4K 4 V8, Canada.
  3. SCIEX , 1201 Radio Road, Redwood City, California 94065, United States.

PMID: 28192911 DOI: 10.1021/acs.analchem.6b04737

Abstract

In recent years, the direct coupling of solid phase microextraction (SPME) and mass spectrometry (MS) has shown its great potential to improve limits of quantitation, accelerate analysis throughput, and diminish potential matrix effects when compared to direct injection to MS. In this study, we introduce the open port probe (OPP) as a robust interface to couple biocompatible SPME (Bio-SPME) fibers to MS systems for direct electrospray ionization. The presented design consisted of minimal alterations to the front-end of the instrument and provided better sensitivity, simplicity, speed, wider compound coverage, and high-throughput in comparison to the LC-MS based approach. Quantitative determination of clenbuterol, fentanyl, and buprenorphine was successfully achieved in human urine. Despite the use of short extraction/desorption times (5 min/5 s), limits of quantitation below the minimum required performance levels (MRPL) set by the world antidoping agency (WADA) were obtained with good accuracy (≥90%) and linearity (R

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