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Kang HH, Ahn KH, Hong SC, et al. Association of citalopram with congenital anomalies: A meta-analysis. Obstet Gynecol Sci. 2017;60(2):145-153doi: 10.5468/ogs.2017.60.2.145.
Kang, H. H., Ahn, K. H., Hong, S. C., Kwon, B. Y., Lee, E. H., Lee, J. S., Oh, M. J., & Kim, H. J. (2017). Association of citalopram with congenital anomalies: A meta-analysis. Obstetrics & gynecology science, 60(2), 145-153. https://doi.org/10.5468/ogs.2017.60.2.145
Kang, Hyun-Hye, et al. "Association of citalopram with congenital anomalies: A meta-analysis." Obstetrics & gynecology science vol. 60,2 (2017): 145-153. doi: https://doi.org/10.5468/ogs.2017.60.2.145
Kang HH, Ahn KH, Hong SC, Kwon BY, Lee EH, Lee JS, Oh MJ, Kim HJ. Association of citalopram with congenital anomalies: A meta-analysis. Obstet Gynecol Sci. 2017 Mar;60(2):145-153. doi: 10.5468/ogs.2017.60.2.145. Epub 2017 Mar 16. PMID: 28344955; PMCID: PMC5364096.
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Obstet Gynecol Sci. 2017 Mar;60(2):145-153. doi: 10.5468/ogs.2017.60.2.145. Epub 2017 Mar 16.

Association of citalopram with congenital anomalies: A meta-analysis.

Obstetrics & gynecology science

Hyun-Hye Kang, Ki Hoon Ahn, Soon-Cheol Hong, Bo Yong Kwon, Eun Hee Lee, Ji-Sung Lee, Min-Jeong Oh, Hai-Joong Kim

Affiliations

  1. Education and Human Resources Department, Samsung Medical Center, Seoul, Korea.
  2. Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
  3. Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
  4. Clinical Research Center, Asan Medical Center, Seoul, Korea.

PMID: 28344955 PMCID: PMC5364096 DOI: 10.5468/ogs.2017.60.2.145

Abstract

OBJECTIVE: The antenatal use of citalopram, a widely prescribed selective serotonin reuptake inhibitor, has been suspected to be associated with congenital, particularly cardiac, anomalies. This study aimed to prove the association between citalopram use and congenital anomalies.

METHODS: We searched the English literature from July 1998 to July 2015, by using the search terms ' citalopram', ' pregnancy', ' birth defects', ' congenital anomalies', and ' malformations' in PubMed, Embase, Web of Science, and the Cochrane Library.

RESULTS: Eight eligible articles were analyzed including a total of 1,507,896 participants. The odds ratio (OR) of major malformations associated with citalopram use during pregnancy was 1.07 (95% confidence interval [CI], 0.98 to 1.17). Concerning cardiac malformations, the OR for all included studies was 1.31 (95% CI, 0.88 to 1.93). The analysis of cardiac malformations was repeated to reduce heterogeneity after excluding one outlier study (OR, 1.03; 95% CI, 0.84 to 1.26).

CONCLUSION: From our data, it can be concluded that citalopram use is not associated with major birth defects. However, physicians should carefully weigh the benefits against the potential risks of citalopram use, and counsel patients accordingly.

Keywords: Citalopram; Congenital anomalies; Heart defects; Meta-analysis; Pregnancy

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