Display options
Cite
Vadasz B, Chen P, Yougbaré I, et al. Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia. Genes Dis. 2015;2(2):173-185doi: 10.1016/j.gendis.2015.02.003.
Vadasz, B., Chen, P., Yougbaré, I., Zdravic, D., Li, J., Li, C., Carrim, N., & Ni, H. (2015). Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia. Genes & diseases, 2(2), 173-185. https://doi.org/10.1016/j.gendis.2015.02.003
Vadasz, Brian, et al. "Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia." Genes & diseases vol. 2,2 (2015): 173-185. doi: https://doi.org/10.1016/j.gendis.2015.02.003
Vadasz B, Chen P, Yougbaré I, Zdravic D, Li J, Li C, Carrim N, Ni H. Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia. Genes Dis. 2015 Jun 01;2(2):173-185. doi: 10.1016/j.gendis.2015.02.003. PMID: 28345015; PMCID: PMC5362271.
Copy Download .nbib Format: NLM
Share it on

Genes Dis. 2015 Jun 01;2(2):173-185. doi: 10.1016/j.gendis.2015.02.003.

Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia.

Genes & diseases

Brian Vadasz, Pingguo Chen, Issaka Yougbaré, Darko Zdravic, June Li, Conglei Li, Naadiya Carrim, Heyu Ni

Affiliations

  1. Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  2. Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada.
  3. Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada.
  4. Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
  5. Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.

PMID: 28345015 PMCID: PMC5362271 DOI: 10.1016/j.gendis.2015.02.003

Abstract

Platelets play critical roles in hemostasis and thrombosis. Emerging evidence indicates that they are versatile cells and also involved in many other physiological processes and disease states. Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life threatening bleeding disorder caused by fetal platelet destruction by maternal alloantibodies developed during pregnancy. Gene polymorphisms cause platelet surface protein incompatibilities between mother and fetus, and ultimately lead to maternal alloimmunization. FNAIT is the most common cause of intracranial hemorrhage in full-term infants and can also lead to intrauterine growth retardation and miscarriage. Proper diagnosis, prevention and treatment of FNAIT is challenging due to insufficient knowledge of the disease and a lack of routine screening as well as its frequent occurrence in first pregnancies. Given the ethical difficulties in performing basic research on human fetuses and neonates, animal models are essential to improve our understanding of the pathogenesis and treatment of FNAIT. The aim of this review is to provide an overview on platelets, hemostasis and thrombocytopenia with a focus on the advancements made in FNAIT by utilizing animal models.

Keywords: Fetal and neonatal alloimmune thrombocytopenia; Integrins and GPIb complex; Platelets and platelet receptors; Thrombosis and hemostasis and Animal models of human disease

References

  1. Circ Res. 2014 Mar 28;114(7):1070-3 - PubMed
  2. Blood. 2011 Mar 17;117(11):3209-13 - PubMed
  3. Blood Res. 2014 Dec;49(4):259-64 - PubMed
  4. J Clin Invest. 2008 Aug;118(8):2929-38 - PubMed
  5. J Thromb Thrombolysis. 2014;37(2):107-17 - PubMed
  6. Ann Intern Med. 1953 Mar;38(3):433-69 - PubMed
  7. Adv Hematol. 2012;2012:384685 - PubMed
  8. Vox Sang. 2003 Oct;85(3):240-5 - PubMed
  9. Thromb Res. 2012 Mar;129(3):220-4 - PubMed
  10. Cell. 1995 Jun 2;81(5):695-704 - PubMed
  11. J Thromb Haemost. 2014 Apr;12(4):497-504 - PubMed
  12. Cardiovasc Hematol Disord Drug Targets. 2008 Dec;8(4):278-82 - PubMed
  13. J Clin Invest. 1989 May;83(5):1778-81 - PubMed
  14. Science. 2012 Dec 7;338(6112):1348-51 - PubMed
  15. Blood. 1997 Oct 1;90(7):2660-9 - PubMed
  16. Transfusion. 2013 Feb;53(2):344-52 - PubMed
  17. Thromb Haemost. 2014 Feb;111(2):279-89 - PubMed
  18. Blood. 2010 Feb 11;115(6):1247-53 - PubMed
  19. Thromb Res. 2010 Mar;125(3):253-6 - PubMed
  20. Lancet. 1990 Aug 4;336(8710):310 - PubMed
  21. J Biol Chem. 1992 Jan 5;267(1):364-9 - PubMed
  22. Cell. 1994 Dec 30;79(7):1157-64 - PubMed
  23. Transfus Sci. 1998 Sep;19(3):237-44 - PubMed
  24. Blood Rev. 2008 Jul;22(4):173-86 - PubMed
  25. Curr Opin Hematol. 2010 Nov;17(6):590-5 - PubMed
  26. Blood. 2003 Aug 1;102(3):887-95 - PubMed
  27. N Engl J Med. 1974 Jan 31;290(5):249-51 - PubMed
  28. Br J Haematol. 2006 Apr;133(1):78-82 - PubMed
  29. Transfusion. 1993 Sep;33(9):739-41 - PubMed
  30. Pediatr Blood Cancer. 2005 Aug;45(2):176-83 - PubMed
  31. Blood. 2002 Jun 1;99(11):4021-9 - PubMed
  32. Transfus Apher Sci. 2003 Jun;28(3):257-64 - PubMed
  33. Transfusion. 2014 Jul;54(7):1698-703 - PubMed
  34. Cardiovasc Hematol Disord Drug Targets. 2013 Mar 1;13(1):50-8 - PubMed
  35. Transfusion. 1986 Nov-Dec;26(6):531-2 - PubMed
  36. N Engl J Med. 1997 Jul 3;337(1):22-6 - PubMed
  37. Transfusion. 2002 Sep;42(9):1173-9 - PubMed
  38. Ann Saudi Med. 1998 Nov-Dec;18(6):547-9 - PubMed
  39. Immunohematology. 2003;19(2):43-6 - PubMed
  40. Transfusion. 2012 Jul;52(7):1468-75 - PubMed
  41. PLoS One. 2012;7(5):e37323 - PubMed
  42. Blood. 2007 Aug 1;110(3):833-9 - PubMed
  43. Nat Med. 2011 Nov 07;17(11):1423-36 - PubMed
  44. J Thromb Haemost. 2006 May;4(5):940-2 - PubMed
  45. Exp Hematol. 2005 Apr;33(4):403-12 - PubMed
  46. Blood. 1998 Oct 1;92(7):2280-7 - PubMed
  47. Nat Rev Immunol. 2007 Sep;7(9):715-25 - PubMed
  48. Thromb Haemost. 2006 Jun;95(6):931-5 - PubMed
  49. J Immunol. 1997 Apr 1;158(7):3221-6 - PubMed
  50. J Thromb Haemost. 2013 Feb;11(2):369-72 - PubMed
  51. Immunology. 1998 Jul;94(3):410-6 - PubMed
  52. Blood. 2006 Apr 1;107(7):2976-83 - PubMed
  53. Hematology. 2013 Nov;18(6):365-9 - PubMed
  54. Nat Med. 2002 Nov;8(11):1227-34 - PubMed
  55. Nat Immunol. 2013 Aug;14(8):768-70 - PubMed
  56. J Biol Chem. 1990 Nov 15;265(32):19833-8 - PubMed
  57. Blood. 2004 Apr 1;103(7):2705-9 - PubMed
  58. J Clin Invest. 2011 Nov;121(11):4537-47 - PubMed
  59. J Thromb Haemost. 2009 Jul;7 Suppl 1:253-7 - PubMed
  60. J Lab Clin Med. 1951 Jul;38(1):1-10 - PubMed
  61. Blood. 2001 Jul 15;98(2):368-73 - PubMed
  62. Transfus Clin Biol. 2001 Jun;8(3):311-4 - PubMed
  63. Blood. 1997 Jun 15;89(12):4402-6 - PubMed
  64. J Pediatr Hematol Oncol. 2003 Aug;25(8):660-4 - PubMed
  65. Curr Opin Hematol. 2012 Nov;19(6):469-74 - PubMed
  66. Blood Rev. 2008 Jan;22(1):33-52 - PubMed
  67. Pediatr Res. 1999 Jul;46(1):28-32 - PubMed
  68. J Pediatr. 2001 Jun;138(6):862-7 - PubMed
  69. Br J Haematol. 2011 Feb;152(4):460-8 - PubMed
  70. J Pharmacol Exp Ther. 2001 Jul;298(1):165-71 - PubMed
  71. Blood. 2003 Dec 15;102(13):4306-11 - PubMed
  72. Nature. 2013 Oct 3;502(7469):105-9 - PubMed
  73. Transfusion. 2012 Jul;52(7):1446-57 - PubMed
  74. Br J Haematol. 2012 Jan;156(2):155-62 - PubMed
  75. J Thromb Haemost. 2005 May;3(5):875-83 - PubMed
  76. BMC Pediatr. 2011 Feb 11;11:16 - PubMed
  77. Prenat Diagn. 1996 Dec;16(12):1152-5 - PubMed
  78. Blood. 2014 Jul 24;124(4):654-5 - PubMed
  79. Mol Hum Reprod. 1996 Mar;2(3):169-75 - PubMed
  80. Blood. 2006 Aug 1;108(3):943-6 - PubMed
  81. Thromb Haemost. 1999 Aug;82(2):337-44 - PubMed
  82. Semin Oncol. 2014 Jun;41(3):422-34 - PubMed
  83. Transfusion. 2009 Oct;49(10):2084-9 - PubMed
  84. Biochim Biophys Acta. 2008 Jun;1783(6):1111-20 - PubMed
  85. J Thromb Haemost. 2004 Aug;2(8):1368-79 - PubMed
  86. Cell Adhes Commun. 1998 Jun;5(4):257-71 - PubMed
  87. Am J Hematol. 2015 May;90(5):E94-5 - PubMed
  88. Thromb Haemost. 2000 Jan;83(1):148-56 - PubMed
  89. Int J Dev Biol. 2005;49(2-3):279-84 - PubMed
  90. J Clin Pathol. 2002 Apr;55(4):289-92 - PubMed
  91. J Thromb Haemost. 2007 Aug;5(8):1740-6 - PubMed
  92. Can J Physiol Pharmacol. 2002 Feb;80(2):116-24 - PubMed
  93. Int Immunol. 2001 Aug;13(8):993-1002 - PubMed
  94. Allergy. 1995;50(25 Suppl):37-44 - PubMed
  95. Pediatr Res. 1986 Apr;20(4):342-6 - PubMed
  96. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1724-31 - PubMed
  97. Am J Obstet Gynecol. 2010 Aug;203(2):135.e1-14 - PubMed
  98. Blood. 1996 Aug 1;88(3):907-14 - PubMed
  99. Prenat Diagn. 2011 Jul;31(7):712-9 - PubMed
  100. J Biol Chem. 1985 Sep 15;260(20):11107-14 - PubMed
  101. J Clin Invest. 2014 Oct;124(10):4281-93 - PubMed
  102. Nat Med. 2013 May;19(5):586-94 - PubMed
  103. Cardiovasc Hematol Disord Drug Targets. 2012 Dec;12(2):126-32 - PubMed
  104. Childs Nerv Syst. 2014 Dec;30(12):2147-50 - PubMed
  105. Nat Rev Immunol. 2011 Apr;11(4):264-74 - PubMed
  106. Blood. 2010 Jul 29;116(4):661-70 - PubMed
  107. Nature. 2004 Nov 4;432(7013):59-67 - PubMed
  108. Blood. 2012 Jun 21;119(25):5949-51 - PubMed
  109. Am J Pediatr Hematol Oncol. 1986 Winter;8(4):312-7 - PubMed
  110. Transfusion. 2012 May;52(5):1117-24 - PubMed
  111. Semin Thromb Hemost. 2006 Apr;32 Suppl 1:32-8 - PubMed
  112. Cell. 2002 Sep 20;110(6):673-87 - PubMed
  113. Transfusion. 2004 Jun;44(6):844-8 - PubMed
  114. Tissue Antigens. 2010 Jun;75(6):673-8 - PubMed
  115. Vox Sang. 2014 Feb;106(2):93-102 - PubMed
  116. Presse Med. 2014 Apr;43(4 Pt 2):e61-7 - PubMed
  117. J Thromb Haemost. 2006 Oct;4(10):2230-7 - PubMed
  118. Front Immunol. 2014 Jan 06;4:504 - PubMed
  119. J Neuroinflammation. 2011 Nov 10;8:157 - PubMed
  120. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2415-9 - PubMed
  121. Nat Med. 2007 Apr;13(4):463-9 - PubMed
  122. J Clin Invest. 2015 Apr;125(4):1545-56 - PubMed
  123. Semin Hematol. 2007 Oct;44(4 Suppl 5):S24-34 - PubMed
  124. Blood. 2003 Nov 15;102(10):3609-14 - PubMed
  125. Vox Sang. 2013 Aug;105(2):167-73 - PubMed
  126. Science. 1994 Apr 22;264(5158):569-71 - PubMed
  127. BMJ Case Rep. 2011 Sep 04;2011: - PubMed
  128. J Clin Invest. 2014 Jan;124(1):273-84 - PubMed
  129. Blood. 2002 Feb 15;99(4):1205-14 - PubMed
  130. Thromb Haemost. 2013 Dec;110(6):1199-206 - PubMed
  131. Blood. 2009 Jun 25;113(26):6511-21 - PubMed
  132. Nat Med. 2003 Sep;9(9):1123-4 - PubMed
  133. Thromb Haemost. 2013 Dec;110(6):1250-8 - PubMed
  134. Blood. 2000 Oct 1;96(7):2520-7 - PubMed
  135. Biol Open. 2013 Apr 11;2(5):525-32 - PubMed
  136. J Biol Chem. 1996 Feb 9;271(6):3046-51 - PubMed
  137. Vox Sang. 1989;57(3):213-7 - PubMed
  138. Transfusion. 2008 Oct;48(10):2077-86 - PubMed
  139. Eur J Haematol. 2009 Aug;83(2):83-9 - PubMed
  140. Autoimmun Rev. 2014 Apr-May;13(4-5):577-83 - PubMed
  141. Blood. 2006 May 1;107(9):3761-3 - PubMed
  142. Br J Haematol. 2013 Aug;162(3):304-12 - PubMed
  143. Nat Rev Microbiol. 2014 Jun;12(6):426-37 - PubMed
  144. Harv Heart Lett. 2014 May;24(9):1, 7 - PubMed
  145. J Reprod Immunol. 1997 Dec 15;37(1):35-61 - PubMed
  146. Platelets. 2015;26(5):495-7 - PubMed
  147. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 1):475-9 - PubMed
  148. Br J Haematol. 1990 Feb;74(2):209-15 - PubMed
  149. Blood. 2009 Jul 9;114(2):425-36 - PubMed
  150. Thromb Haemost. 1998 Mar;79(3):466-78 - PubMed
  151. Obstet Gynecol Surv. 2013 Jul;68(7):526-32 - PubMed
  152. N Engl J Med. 2002 Mar 28;346(13):995-1008 - PubMed
  153. Am J Hematol. 2012 Feb;87(2):206-8 - PubMed
  154. Br J Haematol. 1998 Jan;100(1):62-5 - PubMed
  155. Obstet Gynecol. 2011 Nov;118(5):1157-63 - PubMed
  156. Lancet. 1989 Feb 18;1(8634):363-6 - PubMed
  157. BMJ Open. 2013 Mar 22;3(3): - PubMed
  158. Stem Cells Dev. 2012 Sep 20;21(14):2592-605 - PubMed
  159. J Clin Invest. 1962 May;41:1059-69 - PubMed
  160. Vox Sang. 1990;58(2):176 - PubMed
  161. Nat Med. 2013 May;19(5):541-3 - PubMed
  162. Haematologica. 2010 Nov;95(11):1807-11 - PubMed
  163. Pediatr Res. 1996 Jul;40(1):112-9 - PubMed
  164. Vox Sang. 1994;67 Suppl 3:89-93 - PubMed
  165. Transfusion. 2009 Feb;49(2):265-70 - PubMed
  166. Orphanet J Rare Dis. 2006 Oct 10;1:39 - PubMed
  167. Br J Haematol. 2001 Dec;115(3):679-86 - PubMed
  168. Science. 2007 Sep 21;317(5845):1767-70 - PubMed
  169. Haematologica. 2014 Apr;99(4):e61-3 - PubMed
  170. Blood. 2007 Jun 15;109(12):5087-95 - PubMed
  171. Thromb Res. 2010 May;125(5):e177-83 - PubMed
  172. Annu Rev Immunol. 2007;25:619-47 - PubMed
  173. Haematologica. 1999 Jun;84 Suppl EHA-4:110-4 - PubMed
  174. J Clin Invest. 2000 Aug;106(3):385-92 - PubMed
  175. Blood. 2010 Nov 4;116(18):3660-8 - PubMed
  176. Nucl Med Biol. 1995 Jan;22(1):71-6 - PubMed
  177. Blood. 2009 Feb 19;113(8):1809-17 - PubMed
  178. J Biol Chem. 1998 Apr 3;273(14):7981-7 - PubMed
  179. Thromb Haemost. 1997 Jul;78(1):611-6 - PubMed
  180. J Exp Med. 1988 Jun 1;167(6):2017-22 - PubMed
  181. Transfusion. 2005 Nov;45(11):1799-803 - PubMed
  182. Haematologica. 2008 Jun;93(6):870-7 - PubMed

Publication Types

Grant support