Display options
Share it on

Nanomaterials (Basel). 2013 Jan 31;3(1):86-106. doi: 10.3390/nano3010086.

Investigation of Sub-100 nm Gold Nanoparticles for Laser-Induced Thermotherapy of Cancer.

Nanomaterials (Basel, Switzerland)

Jennifer P Leung, Sherry Wu, Keng C Chou, Ruth Signorell

Affiliations

  1. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada. [email protected].
  2. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada. [email protected].
  3. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada. [email protected].
  4. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada. [email protected].
  5. ETH Zurich, Laboratory for Physical Chemistry, Wolfgang-Pauli-Strasse 10, CH-8093, Zürich, Switzerland. [email protected].

PMID: 28348323 PMCID: PMC5304930 DOI: 10.3390/nano3010086

Abstract

Specialized gold nanostructures are of interest for the development of alternative treatment methods in medicine. Photothermal therapy combined with gene therapy that supports hyperthermia is proposed as a novel multimodal treatment method for prostate cancer. In this work, photothermal therapy using small (<100 nm) gold nanoparticles and near-infrared (NIR) laser irradiation combined with gene therapy targeting heat shock protein (HSP) 27 was investigated. A series of nanoparticles: nanoshells, nanorods, core-corona nanoparticles and hollow nanoshells, were synthesized and examined to compare their properties and suitability as photothermal agents.

Keywords: gene therapy; gold core-corona nanoparticles; gold nanorods; hollow gold nanoshells; light scattering microscopy; prostate cancer

References

  1. Anal Chem. 2007 Mar 15;79(6):2221-9 - PubMed
  2. Nano Lett. 2009 Mar;9(3):1139-46 - PubMed
  3. Nano Lett. 2006 Apr;6(4):662-8 - PubMed
  4. Langmuir. 2009 Oct 6;25(19):11777-85 - PubMed
  5. Br J Cancer. 2003 Sep 1;89(5):937-43 - PubMed
  6. J Am Chem Soc. 2010 Dec 29;132(51):18103-14 - PubMed
  7. BJU Int. 2008 Sep;102(7):786-92 - PubMed
  8. BJU Int. 2006 Nov;98(5):1082-9 - PubMed
  9. Biochem J. 2005 Jun 1;388(Pt 2):573-83 - PubMed
  10. Nat Biotechnol. 2001 Apr;19(4):316-7 - PubMed
  11. Mol Cancer Ther. 2007 Jan;6(1):299-308 - PubMed
  12. Small. 2008 Aug;4(8):1183-95 - PubMed
  13. J Appl Toxicol. 2010 Apr;30(3):212-7 - PubMed
  14. Mol Ther. 2009 Aug;17(8):1387-94 - PubMed
  15. Prostate. 2009 Jul 1;69(10):1077-90 - PubMed
  16. Methods Mol Biol. 2005;303:101-11 - PubMed
  17. Urol Oncol. 2008 Jan-Feb;26(1):93-6 - PubMed
  18. Nat Rev Clin Oncol. 2010 Jul;7(7):394-400 - PubMed
  19. In Vivo. 1997 Mar-Apr;11(2):179-84 - PubMed
  20. Curr Opin Urol. 2005 Sep;15(5):320-7 - PubMed
  21. Int J Hyperthermia. 2002 Nov-Dec;18(6):597-608 - PubMed
  22. Urology. 2008 Dec;72(6 Suppl):S36-43 - PubMed
  23. Bioconjug Chem. 2008 May;19(5):1009-16 - PubMed
  24. Nanotechnology. 2010 Mar 12;21(10):105105 - PubMed
  25. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13549-54 - PubMed
  26. Nano Lett. 2007 Jun;7(6):1542-50 - PubMed
  27. Cancer Res. 2000 Dec 15;60(24):7099-105 - PubMed
  28. Nanotechnology. 2009 Oct 21;20(42):425104 - PubMed
  29. Nano Lett. 2007 May;7(5):1318-22 - PubMed
  30. ACS Nano. 2008 Aug;2(8):1645-52 - PubMed
  31. Int J Hyperthermia. 2004 Nov;20(7):671-7 - PubMed
  32. J Biomater Sci Polym Ed. 2009;20(9):1203-15 - PubMed
  33. BMC Cancer. 2006 Jul 25;6:197 - PubMed
  34. ACS Nano. 2009 Oct 27;3(10):2941-52 - PubMed
  35. Anal Bioanal Chem. 2007 Feb;387(4):1565-72 - PubMed
  36. Lasers Med Sci. 2008 Jul;23(3):217-28 - PubMed
  37. Pharmacol Ther. 2004 Mar;101(3):227-57 - PubMed
  38. Cancer Chemother Pharmacol. 2005 Nov;56 Suppl 1:47-57 - PubMed
  39. J Phys Chem B. 2006 Apr 13;110(14):7238-48 - PubMed
  40. Cancer Res. 2006 Aug 1;66(15):7678-85 - PubMed
  41. J Control Release. 2006 Sep 12;114(3):343-7 - PubMed
  42. Cancer Lett. 2008 Sep 28;269(1):57-66 - PubMed
  43. Oncogene. 2005 May 5;24(20):3328-38 - PubMed

Publication Types