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Corey KE, Gawrieh S, deLemos AS, et al. Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study. World J Hepatol. 2017;9(7):385-390doi: 10.4254/wjh.v9.i7.385.
Corey, K. E., Gawrieh, S., deLemos, A. S., Zheng, H., Scanga, A. E., Haglund, J. W., Sanchez, J., Danford, C. J., Comerford, M., Bossi, K., Munir, S., Chalasani, N., & Wattacheril, J. (2017). Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study. World journal of hepatology, 9(7), 385-390. https://doi.org/10.4254/wjh.v9.i7.385
Corey, Kathleen E, et al. "Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study." World journal of hepatology vol. 9,7 (2017): 385-390. doi: https://doi.org/10.4254/wjh.v9.i7.385
Corey KE, Gawrieh S, deLemos AS, Zheng H, Scanga AE, Haglund JW, Sanchez J, Danford CJ, Comerford M, Bossi K, Munir S, Chalasani N, Wattacheril J. Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study. World J Hepatol. 2017 Mar 08;9(7):385-390. doi: 10.4254/wjh.v9.i7.385. PMID: 28321274; PMCID: PMC5340993.
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World J Hepatol. 2017 Mar 08;9(7):385-390. doi: 10.4254/wjh.v9.i7.385.

Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study.

World journal of hepatology

Kathleen E Corey, Samer Gawrieh, Andrew S deLemos, Hui Zheng, Andrew E Scanga, Jennifer W Haglund, Jorge Sanchez, Christopher J Danford, Megan Comerford, Krista Bossi, Samina Munir, Naga Chalasani, Julia Wattacheril

Affiliations

  1. Kathleen E Corey, Hui Zheng, Jorge Sanchez, Christopher J Danford, Megan Comerford, Krista Bossi, Department of Medicine, Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, United States.

PMID: 28321274 PMCID: PMC5340993 DOI: 10.4254/wjh.v9.i7.385

Abstract

AIM: To identify risk factors associated with hepatocellular carcinoma (HCC), describe tumor characteristics and treatments pursed for a cohort of individuals with nonalcoholic steatohepatitis (NASH) cirrhosis.

METHODS: We conducted a retrospective case-control study of a well-characterized cohort of patients among five liver transplant centers with NASH cirrhosis with (cases) and without HCC (controls).

RESULTS: Ninety-four cases and 150 controls were included. Cases were significantly more likely to be male than controls (67%

CONCLUSION: Male gender, increased age and non-Hispanic ethnicity are associated with HCC in NASH cirrhosis. NASH cirrhosis associated HCC in this cohort was characterized by early stage disease at diagnosis and treatment with locoregional therapy and transplant.

Keywords: Cirrhosis, Gender; Ethnicity; Hepatocellular carcinoma; Nonalcoholic fatty liver disease

Conflict of interest statement

Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.

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