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Koch M, Furtado JD, Falk K, et al. Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma. Alzheimers Dement (Amst). 2017;6:182-187doi: 10.1016/j.dadm.2017.01.007.
Koch, M., Furtado, J. D., Falk, K., Leypoldt, F., Mukamal, K. J., & Jensen, M. K. (2017). Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma. Alzheimer's & dementia (Amsterdam, Netherlands), 6182-187. https://doi.org/10.1016/j.dadm.2017.01.007
Koch, Manja, et al. "Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 6 (2017): 182-187. doi: https://doi.org/10.1016/j.dadm.2017.01.007
Koch M, Furtado JD, Falk K, Leypoldt F, Mukamal KJ, Jensen MK. Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma. Alzheimers Dement (Amst). 2017 Feb 24;6:182-187. doi: 10.1016/j.dadm.2017.01.007. eCollection 2017. PMID: 28289700; PMCID: PMC5338868.
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Alzheimers Dement (Amst). 2017 Feb 24;6:182-187. doi: 10.1016/j.dadm.2017.01.007. eCollection 2017.

Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma.

Alzheimer's & dementia (Amsterdam, Netherlands)

Manja Koch, Jeremy D Furtado, Kim Falk, Frank Leypoldt, Kenneth J Mukamal, Majken K Jensen

Affiliations

  1. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  2. Neuroimmunology Unit, Christian-Albrechts-University Kiel, Kiel, Germany; Department of Neurology, Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel, Germany.
  3. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  4. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Medicine, Channing Division of Network Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

PMID: 28289700 PMCID: PMC5338868 DOI: 10.1016/j.dadm.2017.01.007

Abstract

INTRODUCTION: Subspecies of apolipoproteins can be defined by fractionating apolipoproteins based on the presence and absence of coexisting apolipoproteins.

METHODS: We determined age- and sex-adjusted correlations of enzyme-linked immunosorbent assay-measured plasma and cerebrospinal fluid (CSF) apolipoproteins (apoA-I, apoC-III, apoE, and apoJ) or apolipoprotein subspecies (apoA-I with and without apoC-III, ApoE, or apoJ; apoE with and without apoC-III or apoJ) in 22 dementia-free participants.

RESULTS: CSF apoE did not correlate with plasma apolipoproteins or their subspecies. CSF apoJ correlated most strongly with plasma apoA-I without apoJ (

DISCUSSION: CSF levels of some apolipoproteins implicated in the pathophysiology of dementia might be better approximated by specific plasma apolipoprotein subspecies than total plasma concentrations.

Keywords: Apolipoprotein subspecies; Apolipoproteins; Brain; Cerebrospinal fluid; Lipoproteins

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