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Chem Commun (Camb). 2017 Mar 16;53(23):3354-3356. doi: 10.1039/c7cc00410a.

Electrocatalytic intramolecular oxidative annulation of N-aryl enamines into substituted indoles mediated by iodides.

Chemical communications (Cambridge, England)

Shan Tang, Xinlong Gao, Aiwen Lei

Affiliations

  1. College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei, China. [email protected].
  2. College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei, China. [email protected] and National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, China.

PMID: 28261710 DOI: 10.1039/c7cc00410a

Abstract

An electrocatalytic reaction protocol is developed for achieving intramolecular dehydrogenative annulation of N-aryl enamines. It offers a simple and efficient way for the synthesis of indoles in an undivided cell. Good to excellent yields are obtained under oxidant-free and transition-metal-free conditions. Moreover, imidazo[1,2-a]pyridines could also be produced when N-pyridyl enamines were used as the substrates.

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