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Wang CS, Yan J, Palmer R, et al. Childhood Nephrotic Syndrome Management and Outcome: A Single Center Retrospective Analysis. Int J Nephrol. 2017;2017:2029583doi: 10.1155/2017/2029583.
Wang, C. S., Yan, J., Palmer, R., Bost, J., Wolf, M. F., & Greenbaum, L. A. (2017). Childhood Nephrotic Syndrome Management and Outcome: A Single Center Retrospective Analysis. International journal of nephrology, 20172029583. https://doi.org/10.1155/2017/2029583
Wang, Chia-Shi, et al. "Childhood Nephrotic Syndrome Management and Outcome: A Single Center Retrospective Analysis." International journal of nephrology vol. 2017 (2017): 2029583. doi: https://doi.org/10.1155/2017/2029583
Wang CS, Yan J, Palmer R, Bost J, Wolf MF, Greenbaum LA. Childhood Nephrotic Syndrome Management and Outcome: A Single Center Retrospective Analysis. Int J Nephrol. 2017;2017:2029583. doi: 10.1155/2017/2029583. Epub 2017 Feb 23. PMID: 28326197; PMCID: PMC5343260.
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Int J Nephrol. 2017;2017:2029583. doi: 10.1155/2017/2029583. Epub 2017 Feb 23.

Childhood Nephrotic Syndrome Management and Outcome: A Single Center Retrospective Analysis.

International journal of nephrology

Chia-Shi Wang, Jia Yan, Robert Palmer, James Bost, Mattie Feasel Wolf, Larry A Greenbaum

Affiliations

  1. Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA; Children's Healthcare of Atlanta, 1677 Tullie Circle, Atlanta, GA 30329, USA.
  2. Children's Healthcare of Atlanta, 1677 Tullie Circle, Atlanta, GA 30329, USA.
  3. Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA.

PMID: 28326197 PMCID: PMC5343260 DOI: 10.1155/2017/2029583

Abstract

There is a paucity of information on outpatient management and risk factors for hospitalization and complications in childhood nephrotic syndrome (NS). We described the management, patient adherence, and inpatient and outpatient usage of 87 pediatric NS patients diagnosed between 2006 and 2012 in the Atlanta Metropolitan Statistical Area. Multivariable analyses were performed to examine the associations between patient characteristics and disease outcome. We found that 51% of the patients were treated with two or more immunosuppressants. Approximately half of the patients were noted to be nonadherent to medications and urine protein monitoring. The majority (71%) of patients were hospitalized at least once, with a median rate of 0.5 hospitalizations per patient year. Mean hospital length of stay was 4.0 (3.8) days. Fourteen percent of patients experienced at least one serious disease complication. Black race, frequently relapsing/steroid-dependent and steroid-resistant disease, and the first year following diagnosis were associated with higher hospitalization rates. The presence of comorbidities was associated with longer hospital length of stay and increased risk of serious disease complications. Our results highlight the high morbidity and burden of NS and point to particular patient subgroups that may be at increased risk for poor outcome.

Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

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