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Plotnikova IV, Kovalev IA, Suslova TE, et al. [Correlation of Endothelial Dysfunction With Course of Essential Arterial hypertension in Adolescence]. Kardiologiia. 2015;55(3):21-26
Plotnikova, I. V., Kovalev, I. A., Suslova, T. E., & Bezlyak, V. V. (2015). [Correlation of Endothelial Dysfunction With Course of Essential Arterial hypertension in Adolescence]. Kardiologiia, 55(3), 21-26.
Plotnikova, I V, et al. "[Correlation of Endothelial Dysfunction With Course of Essential Arterial hypertension in Adolescence]." Kardiologiia vol. 55,3 (2015): 21-26.
Plotnikova IV, Kovalev IA, Suslova TE, Bezlyak VV. [Correlation of Endothelial Dysfunction With Course of Essential Arterial hypertension in Adolescence]. Kardiologiia. 2015 Mar;55(3):21-26. Russian. PMID: 28294839.
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Kardiologiia. 2015 Mar;55(3):21-26.

[Correlation of Endothelial Dysfunction With Course of Essential Arterial hypertension in Adolescence].

Kardiologiia

[Article in Russian]
I V Plotnikova, I A Kovalev, T E Suslova, V V Bezlyak

Affiliations

  1. Research Institute for Cardiology of the Research Centre, ul. Kievskaya 111a, 634012 Tomsk, Russia.

PMID: 28294839

Abstract

AIM: to study laboratory parameters of endothelial dysfunction (ED) and their correlation with risk factors (RF) of cardiovascular diseases at early stages of essential arterial hypertension (AH) in adolescents.

MATERIAL AND METHODS: We examined 299 adolescents aged 12 - 18 years with EAH. According to results of 24-hour blood pressure (BP) monitoring all patients were divided into three groups: (1) 98 adolescents with "white coat hypertension", (2) 108 adolescents with liable AH (LAH), (3) 93 patients with stable AH (stAH). Control group consisted of 27 healthy adolescents. Examination included 24-hour BP monitoring, measurement of some laboratory parameters of ED (Von Willebrand factor [vWF], nitric oxide metabolites, urine catecholamines), and assessment of cardiovascular RF.

RESULTS: Mean vWF values in groups (2) and (3) were clinically significantly different from control. Increase of vWF activity by 1 unit was associated with increase of mean nocturnal pulse pressure by 0.36 mm Hg (=0,048). Markers of ED were related to family history of AH, overweight and low birth weight.

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