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De Moudt S, Leloup A, Van Hove C, et al. Isometric Stretch Alters Vascular Reactivity of Mouse Aortic Segments. Front Physiol. 2017;8:157doi: 10.3389/fphys.2017.00157.
De Moudt, S., Leloup, A., Van Hove, C., De Meyer, G., & Fransen, P. (2017). Isometric Stretch Alters Vascular Reactivity of Mouse Aortic Segments. Frontiers in physiology, 8157. https://doi.org/10.3389/fphys.2017.00157
De Moudt, Sofie, et al. "Isometric Stretch Alters Vascular Reactivity of Mouse Aortic Segments." Frontiers in physiology vol. 8 (2017): 157. doi: https://doi.org/10.3389/fphys.2017.00157
De Moudt S, Leloup A, Van Hove C, De Meyer G, Fransen P. Isometric Stretch Alters Vascular Reactivity of Mouse Aortic Segments. Front Physiol. 2017 Mar 16;8:157. doi: 10.3389/fphys.2017.00157. eCollection 2017. PMID: 28360864; PMCID: PMC5352655.
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Front Physiol. 2017 Mar 16;8:157. doi: 10.3389/fphys.2017.00157. eCollection 2017.

Isometric Stretch Alters Vascular Reactivity of Mouse Aortic Segments.

Frontiers in physiology

Sofie De Moudt, Arthur Leloup, Cor Van Hove, Guido De Meyer, Paul Fransen

Affiliations

  1. Laboratory of Physiopharmacology, Department of Pharmaceutical Sciences, University of Antwerp Antwerp, Belgium.
  2. Laboratory of Pharmacology, Faculty of Medicine and Health Sciences, University of Antwerp Antwerp, Belgium.

PMID: 28360864 PMCID: PMC5352655 DOI: 10.3389/fphys.2017.00157

Abstract

Most vaso-reactive studies in mouse aortic segments are performed in isometric conditions and at an optimal preload, which is the preload corresponding to a maximal contraction by non-receptor or receptor-mediated stimulation. In general, this optimal preload ranges from about 1.2 to 8.0 mN/mm, which according to Laplace's law roughly correlates with transmural pressures of 10-65 mmHg. For physiologic transmural pressures around 100 mmHg, preloads of 15.0 mN/mm should be implemented. The present study aimed to compare vascular reactivity of 2 mm mouse (C57Bl6) aortic segments preloaded at optimal (8.0 mN/mm) vs. (patho) physiological (10.0-32.5 mN/mm) preload. Voltage-dependent contractions of aortic segments, induced by increasing extracellular K

Keywords: aorta; contraction; isometric; nitric oxide; preload; relaxation; stretch

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